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  • 1
    Electronic Resource
    Electronic Resource
    Skin mast cell releasability in dogs with atopic dermtitis (1996)
    Springer
    Inflammation research 45 (1996), S. 424-427 
    Details
    ISSN: 1420-908X
    Keywords: Cutaneous mast cells ; Canine atopic dermatitis ; Atopic dermatitis pathogenesis ; Mast cells releasability ; Atopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Isolated dermal mast cells from atopic dogs are a valuable tool for the analysis of their functional properties in atopic dermatitis. We have characterized the histamine secretory pattern of mast cells enzymatically dispersed from the skin of dogs naturally suffering from this condition. The total histamine content found per isolated skin mast cell was higher in the allergic dogs than in nonatopic (control) animals (8.7 pg/mast cell versus 5.2 pg/mast cell). This phenomenon together with the well known higher concentration of skin mast cell number in atopic dermatitis lesions might account for the observed increase in local histamine concentration (15.0 μg/g versus 9.0 μg/g). Atopic dog-derived mast cells were highly reactive to both non-immunological (ionophore A23187) and an immunological-like (concanavalin A) stimulus. Furthermore, histamine net release induced by concanavalin A (1 mg/ml) stimulation was clearly enhanced in the atopic dogs (33.3% net release versus 15.4% in controls). These results have not been described in dermal mast cells dispersed from the skin of individuals with atopic dermatitis and clearly support the hypothesis that mast cells play a major role in causing and possibly modulating atopic dermatitis, through enhanced sensitivity or releasability. however, whether these two phenomena are primary abnormalities of atopic dermatitis, or only secondary changes, remains undetermined.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02252939
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  • 2
    Electronic Resource
    Electronic Resource
    Canine cutaneous mast cells dispersion and histamine secretory characterization
    Amsterdam : Elsevier
    Veterinary Immunology and Immunopathology 39 (1993), S. 421-429 
    Details
    ISSN: 0165-2427
    Keywords: [abr] AD; atopic dermatitis ; [abr] FCS; foetal calf serum ; [abr] HBSS; Hank's balanced salt solution ; [abr] MC; mast cells ; [abr] MEM; Minimum Essential Medium ; [abr] OPT; O-Phthaldialdehyde ; [abr] TCA; trichloroacetic acid
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0165-2427(93)90072-C
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Rapid headspace gas chromatographic method for the determination of liquid/gas partition coefficients
    Amsterdam : Elsevier
    Journal of Chromatography B: Biomedical Sciences and Applications 491 (1989), S. 271-280 
    Details
    ISSN: 0378-4347
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0378-4347(00)82845-5
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  • 4
    Electronic Resource
    Electronic Resource
    Mutagenicity of diphenylhydantoin and some of its metabolites towards Salmonella typhimurium strains
    Amsterdam : Elsevier
    Mutation Research Letters 103 (1982), S. 219-228 
    Details
    ISSN: 0165-7992
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0165-7992(82)90046-X
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  • 5
    Electronic Resource
    Electronic Resource
    Pharmacokinetic Behaviour of Albendazole Sulphoxide Enantiomers in Male and Female Sheep (2000)
    Springer
    Veterinary research communications 24 (2000), S. 339-348 
    Details
    ISSN: 1573-7446
    Keywords: anthelmintic ; benzimidazole ; chromatography ; enantiomer ; metabolism ; pharmacokinetics ; sex ; sheep
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Benzimidazole anthelmintic drugs are widely used in veterinary practice. Albendazole sulphoxide (ABZSO) is a benzimidazole drug with two enantiomers, as a consequence of a chiral centre in the sulphoxide group. The kinetics of these enantiomers were studied in male and female sheep. Plasma samples were obtained from the animals between 0.5 and 72 h after oral administration of 7.5 mg/kg of a racemic formulation of ABZSO (total-ABZSO). After a liquid–liquid extraction, the samples were analysed by HPLC to determine the concentrations of total-ABZSO and of the sulphone metabolite (ABZSO2). During the chromatographic analysis, the ABZSO peak was collected and reanalysed by an HPLC technique using a Chiral AGP column to quantify the enantiomeric proportion therein. After kinetic analysis, the AUCs obtained for the (+)-ABZSO were 5.8 and 4.0 times higher than those for the (–)-ABZSO in male and female animals, respectively. The mean residence times were 23.4 and 16.1 h for (+)-ABZSO and 22.2 and 17.4 h for (–)-ABZSO for male and female animals, respectively. The only significant difference between the sexes (p〈0.05) was in the T max of the (–)-ABZSO. Comparing both enantiomers within each sex, significant differences were found in all the kinetic parameters. Finally, no kinetic differences were found between sex for total-ABZSO or ABZSO2.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006496122684
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  • 6
    Electronic Resource
    Electronic Resource
    Determination of 5,5-diphenylhydantoin and its major metabolites in biological specimens by gas chromatography and selected ion-monitoring (1982)
    Springer
    Chromatographia 15 (1982), S. 509-513 
    Details
    ISSN: 1612-1112
    Keywords: 5,5-Diphenylhydantoin ; GC ; Metabolites ; Selected-ion monitoring
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary A specific and sensitive procedure for simultaneous determination of 5,5-diphenylhydantoin, 5-(4-hydroxyphenyl)-5-phenylhydantoin, 5-(3,4-dihydroxyphenyl)-5-phenylhydantoin and 5-(3-methoxy-4-hydroxyphenyl)-5-phenylhydantoin in biological specimens is described. The method involves formation of butylated or trideuteromethylated derivatives of the drug and its metabolites and analysis by gas chromatography. The lower detectable concentration of these compounds per ml of body fluids or g of wet tissue is either 1 μg or 20 ng, depending on the type of detector used, flame ionization or selected-ion monitoring. Data on the urinary elimination of 5,5-diphenylhydantoin and hydroxylated metabolites in male rats following a single intraperitoneal injection of the drug (25 mg/kg) are also reported.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02260285
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    Paper (German National Licenses)
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