ISSN:
1572-8773
Keywords:
arsenic
;
chronic toxicity
;
chelation
;
DMSA
;
DMPS
;
rat
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
Notes:
Abstract The therapeutic efficacy of two thiol chelators, meso 2,3-dimercaptosuccinic acid (DMSA) or 2,3-dimercaptopropane sulfonate (DMPS) in treating chronic arsenic intoxication was investigated in male rats. Both the chelators were effective in promoting urinary arsenic excretion and restoring arsenic induced inhibition of blood δ-aminolevulinic acid dehydratase activity and hepatic glutathione level. Elevation of urinary δ-aminolevulinic acid excretion and arsenic concentration in blood, liver and kidneys were reduced significantly by both the chelators. Histopathological lesions induced by arsenic were also effectively reduced by the above chelators. DMSA being more effective than DMPS. The results suggest DMSA and DMPS to be effective antidotes for treating chronic arsenic toxicity in experimental animals.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00142009
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