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  • 1
    Electronic Resource
    Electronic Resource
    Anti-GBM nephritis in the mouse: severe proteinuria in the heterologous phase (1985)
    Springer
    Virchows Archiv 406 (1985), S. 285-299 
    Details
    ISSN: 1432-2307
    Keywords: Anti-GBM nephritis ; Complement ; Polymorphonuclear granulocytes ; Mouse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Highly reproducible anti glomerular basement membrane (GBM) nephritis has been induced in the mouse after a single injection of rabbit or goat antibody against purified homologous GBM. The severity of albuminuria was closely related to the amount of antibody given. With doses of 4 mg or more, low serum albumin concentrations, sometimes accompanied by ascites and oedema, were observed after 1 week. Glomerular injury was characterized by an initial accumulation of polymorphonuclear granulocytes followed by thrombosis and necrosis, the extent of which defined the outcome of the glomerulonephritis. With high doses of antibody the exudative lesions entered a chronic phase, while at doses lower than 2 mg remission of the lesions occurred. Immunofluorescence studies showed prompt linear fixation of the injected anti-bodies to the glomerular capillary wall, accompanied by immediate binding of C3 in a fine granular pattern. Fibrin deposits appeared at 2 h in some glomeruli, increased thereafter, and were present after one day in more than 90% of the glomeruli in mice that had received 4 mg of antibody. This new reproducible model in the mouse is suited for the study of the relationship between activation of mediator systems, histological lesions, and proteinuria.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00704298
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The organ distribution of gp-330 (Heymann antigen) and gp-90 in the mouse and the rat (1986)
    Springer
    Virchows Archiv 408 (1986), S. 541-553 
    Details
    ISSN: 1432-2307
    Keywords: Organ distribution ; Heymann antigen ; gp-90 protein ; Mouse ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The Heymann antigen (gp-330) and an antigen with lower molecular weight (gp-90) are major constituents of the brush border of the renal proximal tubules in the rat and the mouse. The Heymann antigen can also be found at discrete sites in the glomerular visceral epithelium of the rat, but not of the mouse. Gp-90 is present diffusely along the glomerular capillary wall of rat and mouse. The Heymann antigen is probably the target antigen for membranous glomerulonephritis in the rat, while in the mouse, where this form of glomerulonephritis can also be induced, gp-90 seems to be the antigen involved. We have separated the antibody populations against these two antigens by preparing eluates from kidneys of rats and livers of mice that had been injected with an antiserum against pronase-digested mouse renal tubular antigens. Using these purified antibodies we have examined by indirect immunofluorescence the distribution of the two antigens on normal mouse and rat tissues. The expression of the Heymann antigen is limited to the epithelia of several organs, while gp-90 has a more widespread distribution in many cells of different origin and function in both the mouse and the rat.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00705307
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Detection of interstitial increase in macrophages, characteristic of acute interstitial rejection, in routinely processed renal allograft biopsies using the monoclonal antibody KP1 (1992)
    Springer
    Transplant international 5 (1992), S. 209-213 
    Details
    ISSN: 1432-2277
    Keywords: Kidney transplantation, biopsy ; Monoclonal antibody, kidney biopsy ; KP1, monoclonal antibody, kidney biopsy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Acute interstitial rejection (AIR) of renal allografts is accompanied by a characteristic peritubular increase in macrophages, which can be identified with the CD14 monoclonal antibody (mAb) WT14 in cryostat sections. Since frozen tissue is not always available, we tested whether this increase can also be demonstrated in Bouin-fixed, paraffin-embedded biopsies, using the CD68 antimacrophage mAb KP1, which can also be applied to paraffin sections. Sections of 16 biopsies with AIR and 11 controls were stained with KP1. In 25 of the 27 biopsies, macrophages were strongly positive for KP1. Two AIR biopsies were completely negative, probably due to prolonged fixation. In the remaining 14 AIR biopsies, the number of KP1-positive cells was significantly higher than in the controls [1184±410 per mm2 (mean±SD) vs 112±126 per mm2]. We conclude that, especially in cases in which frozen tissue is not available, the demonstration of increased numbers of monocytes/macrophages with mAb KP1 can be a helpful adjunct in the histological diagnosis of AIR in routinely processed renal biopsies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00336072
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Jejunal lymphoma in a patient with primary adult-onset hypogammaglobulinemia and nodular lymphoid hyperplasia of the small intestine (1980)
    Springer
    Digestive diseases and sciences 25 (1980), S. 553-557 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A patient is presented with primary adult-onset hypogammaglobulinemia and nodular lymphoid hyperplasia of the small intestine complicated by a jejunal lymphoma. The tumor was resected and was classified as a malignant diffuse histiocytic lymphoma with involvement of mesenteric lymph nodes. Gastroenterological, immunological, histological, and immunopathological studies on this case are reported. The possibility that nodular lymphoid hyperplasia of the small intestine in hypogammaglobulinemia is a premalignant condition is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01315216
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    Paper (German National Licenses)
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