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  • 1
    Electronic Resource
    Electronic Resource
    Total theophylline clearance in childhood: the influence of age-dependent changes in metabolism and elimination (1987)
    Springer
    European journal of pediatrics 146 (1987), S. 41-43 
    Details
    ISSN: 1432-1076
    Keywords: Theophylline ; Pharmacokinetics ; Clearances ; Children
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Theophylline metabolism and elimination during childhood are age-dependent. The total clearance, which is the sum of metabolic and renal clearances is highest in infants and young children. To differentiate between the two pathways, theophylline concentrations were measured in both serum and urine in 16 children aged 2 weeks-16 years using the fluorescence polarization immunoassay. It was found that both partial clearances assume maximal values at about the same age, but the fraction of total clearance attributable to the renal route decreases continuously.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00647281
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  • 2
    Electronic Resource
    Electronic Resource
    Renal clearance of theophylline and its major metabolites: Age and urine flow dependency in paediatric patients (1989)
    Springer
    European journal of clinical pharmacology 36 (1989), S. 145-150 
    Details
    ISSN: 1432-1041
    Keywords: theophylline ; metabolism ; 1,3-dimethyl uric acid ; excretion ; age dependency ; tubular reabsorption ; children ; 3-methylxanthine ; 1-methyluric acid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The renal clearance of theophylline (TH) and its metabolites 1,3-dimethyluric acid (1,3-DMU), 3-methylxanthine (3-MX), and 1-methyluric acid (1-MU) has been studied in 10 children aged 8 months to 14 years. Individual renal clearances were calculated from serum levels and amounts excreted in urine after i.v. administration of the parent drug. The clearance of 1,3-DMU was found to depend both upon urine flow rate and age, which are interrelated. An effect of urinary pH was expected, but was not studied. Consistent age-dependent changes in the relative quantities of metabolites excreted were not observed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00609186
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    A comparison of the multi-test with the prick test and multi-test 2 (1983)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 13 (1983), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Allergy skin testing of infants and small children continues to be time-consuming and nerve-wracking. We hoped to have found the solution to these problems by using the multi-test (MT). The latter consists of an applicator with 8 heads, each head consisting of nine plastic needles on which the allergen solution rests. Thus eight allergens can be tested simultaneously. During routine control skin testing we compared MT with our usual method, the prick test (PT), amongst twenty patients. Twenty-seven percent of the skin reactions differed by more than 1 +. When we compared PT results with the previous PT, the correlation of 16% was better despite several years interval between tests, different persons carrying out the tests, and hyposensitization of patients. We adapted the MT system and produced a model, multi-test 2 (MT-2), which consists of eight sterile disposable needles on a stainless steel base. When we compared the MT-2 with PT, only 6% differed by more than 1 +. Thus the MT-2 proves to be a useful alternative to the PT for those children, in whom the PT is too difficult to carry out.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1983.tb02623.x
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  • 4
    Electronic Resource
    Electronic Resource
    Human antibodies against antigens of the sparrow, blackbird, weaver finch, canary, budgerigar, pigeon and hen using the indirect immunofluorescent technique (1981)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 11 (1981), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Detection of antibodies against various birds, particularly against exotic birds, can be facilitated using the sensitive immunofluorescent technique on avian fixed-intestine cryostat sections. Different fluorescent patterns corresponding to different human anti-avian antibodies have been observed. Sixty of 100 human sera containing antibodies against one avian species, predominantly pigeon, reacted also with all other avian species intestines; the remaining forty were more specific and reacted with a few species only. Cross reactions with antigens in song bird intestines indicate the presence of a broad spectrum of antibodies in patients with bird fancier's lung.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1981.tb01608.x
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  • 5
    Electronic Resource
    Electronic Resource
    The simplified oscillation method for measuring nasal resistance during provocation with allergens (1981)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 11 (1981), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The simplified oscillation method was adapted to register nasal resistance because complicated and difficult procedures limited other known rhinomanometric tests. An initial study of thirty-nine subjects compared the effect of different-sized masks, revealing that the smaller the face mask, the smaller the capacitance and the higher the effective resistance. After an initial measurement, a second study group of twenty healthy and twenty pollinosis patients aged from 4 to 40 years underwent nasal provocation with grass pollen extract. Both study groups showed that despite high resistance, reactances were minor. This occurs because the nose acts as an aperture and an aperture has minimal reactances. With increasing concentrations of pollen extract, the nasal resistance of pollinosis subjects increased steadily, whereas the controls showed no change. Passive anterior rhinomanometry was measured for comparison and results contrasted sharply with the oscillation method: prior to provocation, initial values of control and pollinosis groups were already significantly different; after provocation, there was a statistically significant rise in resistance amongst the control as well as the pollinosis subjects. Further, the oscillation method for measuring nasal resistance proved to be simple, effective, and suitable for children.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1981.tb01609.x
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Therapie-Empfehlungen der Gesellschaft für Pädiatrische Pneumologie zur Behandlung des Asthma bronchiale bei Kindern und Jugendlichen (1998)
    Springer
    Monatsschrift Kinderheilkunde 146 (1998), S. 492-497 
    Details
    ISSN: 1433-0474
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Das Erstmanifestationsalter liegt mit über 80% vor dem 10. Lebensjahr; das Maximum sogar zwischen 3. und 5. Lebensjahr. Jeder Pädiater sollte sich also in Diagnostik und Therapie dieser Erkrankung auskennen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001120050292
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  • 7
    Electronic Resource
    Electronic Resource
    Spontaneous flow measurements of laryngotracheal resistance in 30 tracheostoma patients (1984)
    Springer
    European archives of oto-rhino-laryngology and head & neck 240 (1984), S. 133-137 
    Details
    ISSN: 1434-4726
    Keywords: Tracheostoma ; Laryngotracheal stenoses ; Spontaneous flow ; Airway resistance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The airway resistance of 30 patients with stenosis in the region of the larynx and upper trachea was assessed by means of the spontaneous flow method. For this purpose, the measuring head of a spontaneous flow rhinomanometer (A 440 rhinomanometer, Allergopharma, Reinbek, FRG) was adapted to the new conditions. Laryngotracheal airway resistance between 1.8 and 30 mbar/l/s was registered. This method proved to be suitable for measuring the airway resistance of the larynx and upper trachea in tracheostoma patients with varying degrees of stenosis. Thus, a further objective parameter has been added to those of inspection and X-rays for reviewing the indications for tracheostoma closure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00453470
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  • 8
    Electronic Resource
    Electronic Resource
    Vergleich von aktiver Fremdstromrhinomanometrie (Oszillationsmethode) und aktiver Eigenstromrhinomanometrie bei 17 Patienten vor und nach Nasenscheidewandkorrektur (1983)
    Springer
    European archives of oto-rhino-laryngology and head & neck 237 (1983), S. 115-124 
    Details
    ISSN: 1434-4726
    Keywords: Nasal septum deviation ; Rhinomanometric methods ; External flow (oscillation method) ; Spontaneous flow ; Nasenscheidewandkorrektur ; Nasenwiderstandsmessung ; Eigenstromrhinomanometrie ; Oszillationsmethode
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 17 Patienten mit einer Nasenseptumdeviation wurde vor und nach Nasenscheidewandkorrektur der nasale Strömungswiderstand mit einer aktiven Fremdstrommethode (Oszillationsmethode) und einer Eigenstrommethode gemessen. Die Übereinstimmung der Ergebnisse beider Meßprinzipien ist signifikant. Die Oszillationsmethode ist der Eigenstromrhinomanometrie in ihrer klinischen Anwendbarkeit ebenbürtig, in ihrer Zumutbarkeit überlegen. Sie schließt somit eine Lücke, die entstanden war, weil konventionelle Verfahren zur Nasenwiderstandsmessung insbesondere im Kindesalter häufig versagen.
    Notes: Summary The nasal resistance of 17 patients with nasal septum deviation was measured before and after septum correction using two active rhinomanometric methods; the one with external flow (oscillation method), the other with spontaneous flow. Both methods correlated closely (p〈0.01). The oscillation method proved to be as reliable and sensitive as the spontaneous flow method and less strenuous for the patient. Conventional rhinomanometric methods have failed especially in children because of their great demands on the patient's compliance; thus the oscillation method serves to increase the clinical application of rhinomanometry.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00463610
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