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  • 1
    Electronic Resource
    Electronic Resource
    Polymorphism of tandem repeat in promoter of 5-lipoxygenase in ASA-intolerant asthma: a positive association with airway hyperresponsiveness (2005)
    Oxford, UK : Munksgaard International Publishers
    Allergy 60 (2005), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background:  5-Lipooxygenase (ALOX5) and 5-lipoxygenase-activating protein (ALOX5AP) are known as key enzymes in cysteinyl-leukotriene (cys-LT) production, critical mediators in aspirin acetylsalicyclic acid (ASA)-intolerant asthma (AIA). To date, studies of the promoter region of ALOX5 gene has revealed the potential influence of a variable number of tandem repeats of a Sp1- and Egr1-binding motif, on the transcription rate.Methods:  To understand the pathological process that arises from cys-LT overproduction in AIA, we genotyped ALOX5 Sp1 and ALOX5AP poly(A) repeat promoter polymorphism by fluorescent-based capillary electrophoresis in the Korean population.Results:  No significant differences in allele and genotype frequencies of the ALOX5 and ALOX5AP promoter polymorphisms were observed between the three groups. However, there was a strong association of the ALOX5 Sp1 repeat polymorphism with airway hyperresponsiveness (AHR; PC20 methacholine); AIA patients carrying a mutant allele (n 〉 5 or n 〈 5 repeats) showed increased AHR compared to AIA patients with wild-type genotype (P = 0.003).Conclusion:  Although the alleles of the ALOX5 and ALOX5AP promoter cannot be considered as a prominent risk factor in the development of AIA, the genetic variant of tandem repeat (GGGCGG; Sp1-binding motif) in ALOX5 promoter is associated with the severity of airway hyperresponsiveness in AIA patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.2005.00780.x
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  • 2
    Electronic Resource
    Electronic Resource
    An a.c. impedance study of Lil-Al2O3 composite solid electrolyte (1994)
    Springer
    Journal of materials science 13 (1994), S. 573-576 
    Details
    ISSN: 1573-4811
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00592612
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Fatigue crack initaition and propagation from hole defects (1998)
    Springer
    Experimental mechanics 38 (1998), S. 161-166 
    Details
    ISSN: 1741-2765
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The aim of this study is to investigate the interaction of two hole defects affecting fatigue crack initiation life and propagation behavior. The location of two hole defects was characterized by an angle of alignment and the distance between the centers of two hole defects. The fatigue cracking behavior is studies under bending for AI 5086. When defects are located close to each other, the fatigue crack initiation lives are varied with their relative locations. In the experiments, the area of the local plastic stratin strongly played a role in the fatigue crack initiation lives. Therefore, the authors introduce a parameter which contains the plastic deformation are at stress concentrations and proposed a fatigue crack initiation life prediction curve. In addition, the directions and propagation rates of fatigue cracks initiated at two hole defects were studied experimentally.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02325738
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