Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Action of some surfactants on neuromuscular transmission in frogs (1976)
    Springer
    Neurophysiology 8 (1976), S. 235-239 
    Details
    ISSN: 1573-9007
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of bile salts, saponin, and Tween-80 on miniature end-plate potentials and electrotonic potentials of frog muscle fibers was studied. During the action of bile salts in a concentration of 10−4 g/ml the frequency of the synaptic potentials rose sharply. Their amplitude also increased. The input resistance of the muscle fiber decreased during the action of these substances. With an increase in their concentration to 10−3 g/ml bile salts caused an initial increase in frequency of the spontaneous synaptic potentials followed by their depression and complete disappearance. Tween-80 caused no appreciable change in synaptic activity, whereas saponin inhibited it. Lowering the external calcium ion concentration by two to eight times had no influence on the stimulating effect of bile salts, but the total removal of calcium reduced it. The substances tested stimulated secretion of acetylcholine from the nerve endings, probably through changes caused in the structure of the presynaptic membrane.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01064622
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Effect of sodium glycocholate on neuromuscular transmission in smooth muscle cells of the stomach (1976)
    Springer
    Neurophysiology 8 (1976), S. 414-415 
    Details
    ISSN: 1573-9007
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01063605
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Properties of synaptic currents during nonadrenergic inhibition of smooth-muscle cells of the guinea pig large intestine (1983)
    Springer
    Neurophysiology 15 (1983), S. 462-468 
    Details
    ISSN: 1573-9007
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Using a double sucrose gap method, inhibitory junction potentials (IJP) appeared in muscles of the circular layer of the large intestine in response to intramural stimulation in the presence of atropine. Under voltage clamp conditions, an inhibitory junction current (IJC) in the outward direction appeared in response to the same stimulus, declining exponentially 100–150 msec after the peak. The amplitude of IJC was a linear function of membrane potential; the reversal potential of the peak IJC was in the region of the potassium equilibrium potential. The time constant of decay (τ) depended exponentially on membrane potential, falling by a factor ofe on hyperpolarization by 120 mV. A decrease or increase in quantum composition of IJC caused a corresponding change in τ of IJC decay. Meanwhile apamine (5×10−7 g/ml) reduced the amplitude of IJC without affecting its kinetics. The action of ATP (10−3 M) led to a decrease in amplitude and τ of decay of IJC, evidently on account of occupation of some postsynaptic receptors by ATP. It is suggested that ATP facilitates the delayed diffusion of releasing mediator, by occupying synaptic receptors. Since an increase in the quantity of secreted mediator caused only a very small increase in the amplitude of IJC, it was postulated that under normal conditions the postsynaptic effect of the released mediator is close to maximal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01066122
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Apamin: A highly selective and effective blocker of calcium-dependent potassium conductance (1988)
    Springer
    Neurophysiology 20 (1988), S. 590-600 
    Details
    ISSN: 1573-9007
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02150264
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    The inhibitory action of caffeine on calcium currents in isolated intestinal smooth muscle cells (1991)
    Springer
    Pflügers Archiv 419 (1991), S. 267-273 
    Details
    ISSN: 1432-2013
    Keywords: Single smooth muscle cell ; Caffeine ; Ca store site ; Ca current ; Ca-dependent K current ; Patch-clamp technique
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The patch-clamp method has been used to investigate the action of caffeine on the calcium current (I Ca) in single isolated smooth muscle cells of the guineapig ileum. Caffeine (10 mM) substantially inhibited I Ca. This effect occurred in a biphasic manner and it was not due either to activation of additional ionic currents of opposite direction nor to inhibition of phosphodiesterase activity. It strongly depended upon the ethylenebis(oxonitrilo)tetraacetate (EGTA) concentration in the pipette solution. When there was K+ in the pipette solution, application of caffeine evoked a transient Ca-dependent K+ current and an abrupt and transient increase in the frequency of channel openings. Such well-known blockers of Ca release as procaine and ruthenium red strongly decreased I Ca Ryanodine had only little effect on I Ca, but application of caffeine in the presence of ryanodine led to a complete and irreversible inhibition of I Ca. The results of experiments involving different EGTA concentrations and comparison of the time courses of all caffeine-induced phenomena clearly indicated that only the initial, transient component of the I Ca inhibition by caffeine was related to a Ca-dependent inactivation of Ca channels, evoked as a result of Ca release from intracellular stores. The tonic component of I Ca inhibition was probably due to a direct blocking action of caffeine on Ca channels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00371106
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Effect of some surfactants on neuromuscular transmission of excitation (1976)
    Springer
    Bulletin of experimental biology and medicine 81 (1976), S. 128-131 
    Details
    ISSN: 1573-8221
    Keywords: microelectrode method ; surfactants ; end-plate potential
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The effect of the sodium salts of bile acids (BA), saponin, and Tween 80 on end-plate potentials (EPPs) of the myoneural junction of the frog sartorius muscle was investigated by a microelectrode method. Salts of BA in a concentration of 10−5 g/ml had no appreciable effect on these potentials, but with an increase in their concentration to 10−4 g/ml the amplitude of the EPPs was increased by 1.5–3 times. During the action of BA in a concentration of 10−3 g/ml the same effect was observed, but there was a much more rapid increase in amplitude of the EPPs followed by a decrease. Saponin and Tween 80 were less effective as regards the EPPs, but they did affect the contractile activity of the muscle. The increase in amplitude of EPPs under the influence of the substances tested is due principally, it is suggested, to stimulation of the liberation of acetylcholine by nerve terminals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00801047
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...