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  • 1
    Electronic Resource
    Electronic Resource
    Salt-sensitivity is associated with a hyperinsulinaemic and hyperglycaemic response to atrial natriuretic peptide infusion in human essential hypertension (1994)
    Springer
    Diabetologia 37 (1994), S. 308-312 
    Details
    ISSN: 1432-0428
    Keywords: Hypertension ; atrial natriuretic peptide ; insulin ; salt-sensitivity ; kidney
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To evaluate the influence of salt-sensitivity on the plasma insulin and glucose response to infusion of ANP, we studied 22 men with essential hypertension, who were between 40 and 60 years old. After 1 month under normal Na+ intake (120 mmol Na+ per day), patients were randomly assigned to receive either ANP (0.04 μg · kg−1 · min−1) (n=15) or vehicle (50 ml saline) (n=7) over a 60-min period, while in the supine position. Plasma insulin and glucose were measured at time −60, 0, 20, 40, 60, 120, 180, 240 min. Ten days after ANP infusion, blood pressure sensitivity to changes in di etary salt intake was assessed according to a randomized double-blind crossover protocol. Patients were classified into two groups either salt-sensitive (n=8) or salt-resistant (n=7). Our results showed that plasma insulin and glucose did not change during ANP infusion in both groups. However, both plasma insulin (from 75.6 ± 45.1 pmol/l at 60 min to 121.2 ± 48.6 pmol/l at 240 min, p 〈0.05 vs time 0) and glucose levels (from 4.86 ± 0.73 mmol/l at 60 min to 6.56 ± 1.03 mmol/l at 240 min, p 〈0.01 vs time 0) rose after discontinuation of ANP in salt-sensitive patients, but did not change at all in salt-resistant patients. In conclusion, this randomized vehicle-controlled study demonstrates that plasma insulin and glucose levels increase in salt-sensitive hypertensive patients after the infusion of ANP. The increase of plasma insulin levels observed after ANP discontinuation, if occurring under physiologic conditions, could influence the blood pressure sensitivity to dietary Na+ intake.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00398059
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  • 2
    Electronic Resource
    Electronic Resource
    Salt-sensitivity is associated with a hyperinsulinaemic and hyperglycaemic response to atrial natriuretic peptide infusion in human essential hypertension (1994)
    Springer
    Diabetologia 37 (1994), S. 308-312 
    Details
    ISSN: 1432-0428
    Keywords: Key words Hypertension, atrial natriuretic peptide, insulin, salt-sensitivity, kidney. [Diabetologia (1994) 37: 308–312]
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To evaluate the influence of salt-sensitivity on the plasma insulin and glucose response to infusion of ANP, we studied 22 men with essential hypertension, who were between 40 and 60 years old. After 1 month under normal Na+ intake (120 mmol Na+ per day), patients were randomly assigned to receive either ANP (0.04 µg·kg−1·min−1) (n =15) or vehicle (50 ml saline) (n =7) over a 60-min period, while in the supine position. Plasma insulin and glucose were measured at time –60, 0, 20, 40, 60, 120, 180, 240 min. Ten days after ANP infusion, blood pressure sensitivity to changes in dietary salt intake was assessed according to a randomized double-blind crossover protocol. Patients were classified into two groups either salt-sensitive (n =8) or salt-resistant (n =7). Our results showed that plasma insulin and glucose did not change during ANP infusion in both groups. However, both plasma insulin (from 75.6±45.1 pmol/l at 60 min to 121.2±48.6 pmol/l at 240 min, p〈0.05 vs time 0) and glucose levels (from 4.86±0.73 mmol/l at 60 min to 6.56±1.03 mmol/l at 240 min, p〈0.01 vs time 0) rose after discontinuation of ANP in salt-sensitive patients, but did not change at all in salt-resistant patients. In conclusion, this randomized vehicle-controlled study demonstrates that plasma insulin and glucose levels increase in salt-sensitive hypertensive patients after the infusion of ANP. The increase of plasma insulin levels observed after ANP discontinuation, if occurring under physiologic conditions, could influence the blood pressure sensitivity to dietary Na+ intake.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00398059
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Inhibition by picotamide of thromboxane production in vitro and ex vivo (1988)
    Springer
    European journal of clinical pharmacology 33 (1988), S. 599-602 
    Details
    ISSN: 1432-1041
    Keywords: picotamide ; thromboxane A2 ; platelet aggregation ; thromboxane A2 synthetase inhibitors ; prostacyclin production
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of picotamide on platelet function has been studied in vitro and ex vivo. Picotamide at micromolar concentrations inhibited platelet aggregation induced by ADP, arachidonic acid and collagen, and it also inhibited the production of thromboxane A2 (TxA2). Unlike aspirin, picotamide did not affect the synthesis of prostacyclin by blood vessels. In eight healthy subjects who took picotamide 1200 mg/d platelet aggregation and TxA2 production were inhibited. Picotamide appears to be an antiplatelet drug that reduces TxA2 synthesis without affecting cyclooxygenase activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542494
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Effect of oral defibrotide on tissue-plasminogen activator and tissue-plasminogen activator inhibitor balance (1992)
    Springer
    European journal of clinical pharmacology 42 (1992), S. 379-383 
    Details
    ISSN: 1432-1041
    Keywords: Atherosclerosis ; Defibrotide ; fibrinolysis ; tissue plasminogen activator t-PA ; plasminogen activator inhibitor PAI 1
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Defibrotide, a polydeoxyribonucleotide of mammalian origin, has been shown to reduce the blood level of the plasminogen activator inhibitor, and so to increase the activity of tissue plasminogen activator without any adverse effect. A randomized, double-blind, placebo-controlled study has been done in 22 patients, 14 with peripheral vascular disease, 6 with coronary heart disease and 2 with cerebrovascular disease. Patients were given defibrotide 400 mg b.d. or identical placebo for 30 days and the parameters of fibrinolysis were evaluated before and after the treatment. A significant increase in tissue plasminogen activator activity at rest and after venostasis was observed after defibrotide; tissue plasminogen activator antigen at rest and after venostasis was not affected by either treatment. Defibrotide significantly reduced plasminogen activator inhibitor activity and antigen at rest. Only one patient complained of gastric pain after placebo treatment. The study shows that defibrotide has profibrinolytic property and that it could be used to explore the role of plasminogen activator inhibitor in venous and arterial thrombosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00280122
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Tumor Necrosis Factor-Alpha and Interferon-Gamma Synthesis by Cerebrospinal Fluid-Derived T Cell Clones in Multiple Sclerosis (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 650 (1992), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1992.tb49149.x
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Free radical-mediated platelet activation by hemoglobin released from red blood cells
    Amsterdam : Elsevier
    Archives of Biochemistry and Biophysics 299 (1992), S. 220-224 
    Details
    ISSN: 0003-9861
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0003-9861(92)90267-Z
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Vitamin C inhibits platelet lipoxygenase and cyclogenase pathways
    Amsterdam : Elsevier
    Prostaglandins 27 (1984), S. 103 
    Details
    ISSN: 0090-6980
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0090-6980(84)90348-4
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  • 8
    Electronic Resource
    Electronic Resource
    Ambulatory blood pressure recording in diabetic patients with abnormal responses to cardiovascular autonomic function tests (1992)
    Springer
    Acta diabetologica 28 (1992), S. 221-228 
    Details
    ISSN: 1432-5233
    Keywords: Blood pressure ; Nycthermal rhythm ; Diabetic autonomic neuropathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The aim of our study was to analyse the 24-h periodic pattern of blood pressure (BP) in diabetic patients with abnormal responses to cardiovascular reflexes, in order to evaluate the extent of the initial autonomic damage. We studied 44 patients with diabetes mellitus (14 insulin-dependent, 30 non-insulin-dependent; mean duration of disease 6.5±1.8 years) in good metabolic control (fasting glycaemia 〈140 mg/dl, postprandial glycaemia 〈180 mg/dl, fructosamine 〈285 mg/dl), divided into two subgroups, containing 21 normotensives (13 males and 8 females aged 28–72 years) and 23 hypertensives (13 males and 10 females aged 32–70 years) respectively. All patients showed abnormal responses to at least two out of four tests: deep breathing, lying to standing, Valsalva manœuvre and postural hypotension. Two sex-and age-matched control groups were recruited, comprising 20 normotensive and 20 hypertensive diabetic patients without dysautonomia, respectively. The reference group consisted of 248 normotensives (135 males and 113 females, aged 18–76 years) and 212 mild-moderate hypertensives (130 males and 82 females, aged 27–66 years). Each patient underwent ambulatory BP monitoring for at least 24 h, using an auscultatory automatic device. Data concerning biological rhythms were analysed by means of periodic functions. We limited the Fourier partial sums to the first three harmonics. In the diabetic normotensive groups, we observed that the absolute systolic and diastolic BP minima during the night occurred very rapidly and that the increase to the morning maximum was markedly slowed in patients with abnormal responses to cardiovascular tests in comparison with the controls (nocturnal BP decrease −5.8/−4.7 vs −3.8/−4.0 mm Hg/h; increase 4.7/3.6 vs 5.9/6.1 mm Hg/h). The same phenomenon was observed in both hypertensive groups but the differences were more marked (nocturnal BP decrase −7.7/−7.1 vs −4.3/−3.9 mm Hg/h; increase 3.2/2.1 vs 5.8/4.3 mm Hg/h). Diabetic patients without dysautonomia had similar patterns to those in the normotensive and hypertensive reference groups. Since alterations in circadian rhythm are preceded by an intermediate smoothed BP curve during the early morning, which is well defined by Fourier analysis and related “speeds”, this method makes it possible to quantify the extent of the initial autonomic damage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00779003
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    Early nocturnal blood pressure changes in diabetic autonomic neuropathy assessed by Fourier series (1993)
    Springer
    Clinical autonomic research 3 (1993), S. 249-254 
    Details
    ISSN: 1619-1560
    Keywords: Blood pressure ; Circadian rhythm ; Fourier series ; Dysautonomia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The 24 h periodic pattern of blood pressure was studied in 44 patients with diabetes mellitus (14 type 1, 30 type 2; mean duration of disease 6.5 ± 1.8 years) in good metabolic control but with abnormal cardiovascular reflex responses; of these 21 were normotensive and 23 hypertensive. All had abnormal responses to at least two out of four tests: deep breathing, lying to standing, Valsalva manoeuvre and postural hypotension. Two sex- and agematched groups, consisting of 20 normotensive and 20 hypertensive diabetic patients without dysautonomia, were studied as controls. Each patient underwent ambulatory blood pressure monitoring for at least 24 h, using an auscultatory automatic device. Data were analysed using the sum of three periodic functions (Fourier partial sum). In the diabetic normotensive groups, the absolute blood pressure fell to its night-time minimum more rapidly, and increased to its morning maximum more slowly, in those with abnormal cardiovascular reflexes than in the controls (nightly blood pressure decrease −5.8/−4.7 vs. −3.8/−4.0 mmHg/h; increase 4.7/3.6 vs. 5.9/6.1 mmHg/h). The same behaviour was found in both hypertensive groups but the amplitude of the differences was more marked (blood pressure nocturnal decrease −7.7/−7.1 vs. −4.3/−3.9 mmHg/h; increase 3.2/2.1 vs. 5.8/4.3 mmHg/h). This analysis of 24 h ambulatory blood pressure data may be of value in diagnosis and evaluation of autonomic deficits.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01829014
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