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  • 1
    Electronic Resource
    Electronic Resource
    Second-line treatment for failure to eradicate Helicobacter pylori: a randomized trial comparing four treatment strategies (2003)
    Oxford, UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 18 (2003), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aim : To compare the efficacy of different regimens in patients in whom previous Helicobacter pylori eradication therapy has failed.Methods : In this study named StratHegy patients (n = 287) were randomized to receive one of three empirical triple therapy regimens or a strategy based on antibiotic susceptibility. The empirical regimens were omeprazole, 20 mg b.d., plus amoxicillin, 1000 mg b.d., and clarithromycin, 500 mg b.d., for 7 days (OAC7), clarithromycin, 500 mg b.d., for 14 days (OAC14) or metronidazole, 500 mg b.d., for 14 days (OAM14). In the susceptibility-based strategy, patients with clarithromycin-susceptible strains received OAC14, whilst the others received OAM14. The 13C-urea breath test was performed before randomization and 4–5 weeks after eradication therapy.Results : In the intention-to-treat analysis, the eradication rates for empirical therapies were as follows: OAC7, 47.4% (27/57); OAC14, 34.5% (20/58); OAM14, 63.2% (36/57); it was 74.3% (84/113) for the susceptibility-based treatment (P 〈 0.01 when compared with OAC7 and OAC14). In patients receiving clarithromycin, the eradication rates were 80% for clarithromycin-susceptible strains and 16% for clarithromycin-resistant strains; in patients receiving OAM14, the eradication rates were 81% for metronidazole-susceptible strains and 59% for metronidazole-resistant strains.Conclusions : Eradication rates of approximately 75% can be achieved with second-line triple therapy based on antibiotic susceptibility testing. If susceptibility testing is not available, OAM14 is an appropriate alternative.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.2003.01759.x
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  • 2
    Electronic Resource
    Electronic Resource
    Treating the symptoms of gastro-oesophageal reflux disease: a double-blind comparison of omeprazole and cisapride (1997)
    Oxford, UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 11 (1997), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: Few studies have specifically addressed the management of the symptoms of gastro-oesophageal reflux disease, and there are no comparative data in this respect for acid pump inhibitors and prokinetic agents. Methods: Following endoscopy 424 patients presenting with heartburn as the predominant symptom of gastro-oesophageal reflux disease were randomized to treatment with omeprazole 20 or 10 mg once daily, or cisapride 10 mg four times daily, in a double-blind, double-dummy, parallel group, multicentre study. Symptoms and quality of life were assessed at 4 weeks. Patients still experiencing heartburn continued therapy for a further 4 weeks and the assessments were repeated. Results: At 4 weeks, heartburn was resolved in 65% (95% CI: 57–73%), 56% (48–64%) and 41% (32%–49%) of patients treated, respectively, with omeprazole 20 mg and 10 mg once daily, and cisapride. Both omeprazole doses were significantly more effective than cisapride (P 〈 0.01). The same order of efficacy was observed regardless of the presence of erosive oesophagitis. Regurgitation and epigastric pain also improved to a greater degree with omeprazole than with cisapride. Quality of life was improved in all treatment groups, and the improvement in the reflux dimension of the Gastrointestinal Symptom Rating Scale (GSRS) score was significantly different between groups (P = 0.002). Conclusions: Omeprazole 20 or 10 mg once daily is significantly more effective than cisapride in the resolution of heartburn, regardless of the presence of erosive oesophagitis, and this is accompanied by an improvement in patient quality of life.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.1997.00185.x
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  • 3
    Electronic Resource
    Electronic Resource
    Omeprazole-amoxycillin versus omeprazole-amoxycillin-clarithromycin in the eradication of Helicobacter pylori. (1996)
    Oxford, UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 10 (1996), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: AIM: To assess the effect of adding clarithromycin to the combination of omeprazole and amoxycillin for the eradication of H. pylori infection. PATIENTS AND METHODS: In an open, randomized, three-centre study 120 patients (69 men, mean age 47 years, caucasians 74%) with symptoms of dyspepsia had normal gastroscopic examination and a positive urease test. They underwent a 13C-urea breath test and received, for 14 days, either omeprazole 40 mg b.d. plus amoxycillin 750 mg b.d., or the same regimen plus clarithromycin 250 mg b.d. Compliance was assessed by returned tablet counts. H. pylori clearance at the end of treatment and eradication 4 weeks after finishing treatment were assessed by 13C-urea breath test. RESULTS: Results are expressed according to 'all patients treated analysis', excluding patients who did not receive treatment and patients who had no final 13C-urea breath test assessment. In the groups treated with omeprazole- amoxycillin or omeprazole-amoxycillin-clarithromycin good compliance (〉 or = 90%) was observed in 85% vs. 76% (N.S.) of patients but 25% vs. 34% (N.S.) experienced at least one adverse event. Adverse events were minor, and no patient reported a metallic taste. Four weeks after finishing treatment eradication rates were 26% (95% CI: 15-37%) vs. 93% (95% CI: 86-99%) (P 〈 0.001). CONCLUSION: These results show that dual therapy with omeprazole plus amoxycillin achieves an unacceptably low H. pylori eradication rate. Addition of clarithromycin at low dosage (250 mg b.d.) proved to be useful, achieving a high eradication rate without increasing side-effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0953-0673.1996.00263.x
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  • 4
    Electronic Resource
    Electronic Resource
    A randomized comparison of four omeprazole-based triple therapy regimens for the eradication of Helicobacter pylori in patients with non-ulcer dyspepsia (2001)
    Oxford UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 15 (2001), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Helicobacter pylori eradication rates in France after therapy with omeprazole, amoxicillin and clarithromycin are among the lowest in Europe. This study evaluated alternative eradication regimens.〈section xml:id="abs1-2"〉〈title type="main"〉Methods: Helicobacter pylori-positive patients (n=323) with non-ulcer dyspepsia were randomized to receive one of four 1-week regimens consisting of omeprazole, 20 mg b.d., plus either: amoxicillin, 1000 mg b.d., and clarithromycin, 500 mg b.d. (OAC); bacampicillin, 1200 mg b.d., and clarithromycin, 500 mg b.d. (OBC); clarithromycin, 250 mg b.d., and metronidazole, 500 mg b.d. (OCM); or amoxicillin, 1000 mg b.d, and azithromycin, 500 mg on day 1 and 250 mg on days 2–5 (OAAz). Eradication was confirmed by urea breath test 4–6 weeks after treatment. Susceptibility testing was performed in the case of eradication failure.〈section xml:id="abs1-3"〉〈title type="main"〉Results:The eradication rate with OAAz was 38% (95% CI, 25.6–49.4) on intention-to-treat analysis, which was lower (P 〈 0.05) than with the other regimens [OCM, 61% (50.0–72.8); OBC, 65% (54.0–76.5); OAC, 72% (61.8–81.8)]. Of the strains isolated following treatment failure with OAC, OBC or OCM, 84% were clarithromycin resistant.〈section xml:id="abs1-4"〉〈title type="main"〉Conclusions:OAC remains the reference treatment for H. pylori eradication in France, although bacampicillin offers a useful alternative to amoxicillin. Susceptibility testing should be considered after unsuccessful eradication therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.2001.01104.x
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  • 5
    Electronic Resource
    Electronic Resource
    Interaction between SO"2 and cold-induced bronchospasm in anesthetized rabbits
    Amsterdam : Elsevier
    Respiration Physiology 71 (1988), S. 1-10 
    Details
    ISSN: 0034-5687
    Keywords: Atmospheric pollutant ; Cold air ; Lung resistance ; Vagal reflexes
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0034-5687(88)90110-7
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  • 6
    Electronic Resource
    Electronic Resource
    In vivo and in vitro studies on cold-induced airway response in normal and sensitized rabbits
    Amsterdam : Elsevier
    Respiration Physiology 73 (1988), S. 1-10 
    Details
    ISSN: 0034-5687
    Keywords: Cold ; In vitro ; In vivo ; Rabbit ; Sensitization ; Tracheal smooth muscle
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0034-5687(88)90122-3
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  • 7
    Electronic Resource
    Electronic Resource
    Cold-induced bronchospasm in normal and sensitized rabbits
    Amsterdam : Elsevier
    Respiration Physiology 63 (1986), S. 347-360 
    Details
    ISSN: 0034-5687
    Keywords: Airway ; Bronchospasm ; Rabbit ; Resistance ; Smooth muscle ; Vagus nerve
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0034-5687(86)90101-5
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  • 8
    Electronic Resource
    Electronic Resource
    Repiratory effects of cold air breathing in anesthetized cats
    Amsterdam : Elsevier
    Respiration Physiology 54 (1983), S. 41-54 
    Details
    ISSN: 0034-5687
    Keywords: Breathing pattern ; Bronchomotricity ; Diaphragm ; Larynx ; Lower airways ; Lung resistance ; Superior laryngeal nerve ; Temperature ; Trachea ; Vagal block
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0034-5687(83)90112-3
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  • 9
    Electronic Resource
    Electronic Resource
    Evaluation of wood characteristics: Internal scanning of the material by microwaves (1987)
    Springer
    Wood science and technology 21 (1987), S. 361-371 
    Details
    ISSN: 1432-5225
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Summary Internal scanning of wood by microwaves presents many advantages for the automatic detection of defects and the evaluation of the characteristics of wood in the dry wood processing industries. Advantages are: access to more than one variable, efficient coupling in the air, easy automation and reasonable cost. Microwaves are electromagnetic waves the speed and attenuation of which depend of the medium in which they are propagated, especially its electric permittivity which depends on its moisture content and its density. Since wood is anisotropic, this dielectric constant also varies with the direction of fibers. An experimental apparatus was set up that allows to test the feasibility of automatic detection of wood characteristics and defects. It automatically measures the attenuation and dephasing of an ultra high frequency wave sent through a board and moving through two rotating antennas. The graphs and results obtained gave significant information of physical characteristics of wood (density, moisture content, slope of grain) and the detection of defects (knots, metallic objects, sapwood).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00380203
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  • 10
    Electronic Resource
    Electronic Resource
    Structure of 11,14,27,30,35,38,43,46-octaoxa-1,8,17,24-tetraazapentacyclo[22.8.8.88,17.23,6.219,22]dopentaconta-3,5,19,21,49,51-hexaene, C40H64N4O8, a tricyclic macrocycle featuring two [18]-N2O4 binding subunits and two benzene bridges (1984)
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 40 (1984), S. 484-486 
    Details
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108270184004583
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