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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 101 (1994), S. 0 
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective To investigate the effect of age on the control of the reproductive cycle in regularly menstruating women.Design In this prospective study all women were seen regularly during both the follicular and luteal phases. Ultrasound scanning was used to confirm ovulation and measurements were taken to assess follicular development and endometrial thickness. Serum gonadotrophin levels on day 4 of the cycle, the maximum periovulatory oestradiol and progesterone on the seventh day after ovulation were measured and compared in different age groups.Subjects & Setting Fifty-six healthy, regularly menstruating women were recruited from volunteers amongst staff of the University Hospital of South Manchester.Results Ovulation occurred later in the cycle for older women, with mean follicular phase length increasing from 13.9 days (in group 21–25 years) to 15–9 days (in group 37–45 years (P 〈 0.05). The mean of the maximum follicular diameter prior to rupture was significantly smaller in the older women: 16.7 mm in the 37 to 45 years old group compared with 19.6 mm, 21.6 mm and 21.3 mm in the 21 to 25, 26 to 31 and 32 to 36 years old age groups, respectively (P 〈 0.001). The maximum thickness of the endometrium in the luteal phase was greatest for older women: 15.9 mm in the age group 37 to 45 years compared with 12.1 mm in the age group 21 to 25 years (P 〈 0.001). Serum gonadotrophin concentrations during menses were higher with increased age; mean follicle stimulating hormone was 4.8 iu/l in the age group 21 to 25 years, and 8.5 iu/l in the age group 37 to 45 years (P 〈 0.001). Mean luteinising hormone was 4.5 iu/l in age group 21 to 25 years and 7.21 iu/l in age group 37 to 45 years (P 〈 0.001). Mean ovarian steroid concentrations were no different.Conclusions These data illustrate significant age related differences in the pituitary-ovarian axis and endometrial thickness. This has implications for the management of older women in assisted reproduction and fertility control programmes.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Reaction kinetics and catalysis letters 1 (1974), S. 135-140 
    ISSN: 1588-2837
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Abstract Иод быстро взаимодействует с цианидным ионом, но не реагирует непосредственно с цианидом, связанным с металлом. Позтому он является эффективной ловушкой, которая позволяет исследовать скорость диссоциации ряда цианидных комплексов металлов. Для последней был найден следующий ряд: Cd(CN)4 2−≫Ni(CN)4 2−≫Pd(CN)4 2−≫Fe(CN)6 3−}Co(CN)6 3−
    Notes: Abstract Iodine react repidly with cyanide ion but does not react directly with metal-bound cyanide. It is therefore an effective scavenger which permits studies of the dissociation rates of a number of metal cyanide complexes. The rates Cd(CN)4 2−≫Ni(CN)4 2−≫Pd(CN)4 2−≫Fe(CN)6 3−}Co(CN)6 3− are found.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1588-2780
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract The isotope260Lr, produced in reactions of18O with249Bk, was used to perform chemical experiments on lawrencium to learn more about its chemical properties. These experiments involved extractions with thenoyl trifluoroacetate, elutions from cation exchange resin columns with ammonium alpha-hydroxyisobutyrate, and reverse-phase chromatography using hydrogen di(2-ethylhexyl) orthophosphoric acid to investigate the chemical properties of Lr. The results from the elutions gave information about the ionic radius of Lr(III) which was found to elute very close to Er. An attempt to reduce Lr(III) with hydroxylamine hydrochloride was unsuccessful.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Psychopharmacology 93 (1987), S. 292-295 
    ISSN: 1432-2072
    Keywords: Diazepam ; Drug discrimination ; Aged ; Rats ; Chlordiazepoxide ; Pentobarbital ; Methocarbamol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Young adult rats (5 months) were compared with aged (28 months) rats in their ability to learn and perform in a diazepam drug discrimination. Both groups of rats were drug naive at the onset of the experiment. Adult and aged animals learned to discriminate diazepam. In general, the response rates under both drug and vehicle conditions were significantly lower for the aged group. The diazepam stimuli were dose-dependent in each group. Similar dose-dependent generalization with chlordiazepoxide, pentobarbital, and methocarbamol was also noted in both the aged and adult animals. These data suggest that aged animals, who have experienced anxiolytic compounds over a period of time (in this case, repeated administration of diazepam in the discrimination procedure), respond in a similar fashion to drug treatment as do young adult animals, verifying the reliability and validity of results obtained in aging rats who are repeatedly exposed to drug treatment.
    Type of Medium: Electronic Resource
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