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  • 1
    ISSN: 1432-0533
    Keywords: Fetal nerve ; Fcγ receptor ; C3b/C4b receptor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The ontogenesis of Fcγ receptors (FcR) and C3b/C4b receptors (CR1) was studied in peripheral nerves from ten fetuses aged from 20 to 38 weeks using immunohistochemical and functional assays. Monoclonal antibodies (mAbs) against FcR and CR1 stained nerve fibers at 10 weeks of gestation and the staining intensity increased during nerve maturation. FcR and CR1 are probably expressed on Schwann cells and are early markers during the development of peripheral nerves. Functional FcR activity was detected in nerve sections before initiation of myelination, which occurs at approximately 18–19 weeks, whereas functional CR1 activity was found in the sections after myelination. Functional CR1 activity may, therefore, be related to myelin. The ontogenesis of FcR and CR1 was also studied on Schwann cells in culture from three fetuses aged 14, 16 and 19 weeks, using immunofluorescence technique with mAbs. The FcR and CR1 are lost on cultured Schwann cells. This suggests that the receptors are not intrinsic to the cells or that Schwann cells require axonal contact for the expression of FcR and CR1.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Vacuum 41 (1990), S. 1479-1480 
    ISSN: 0042-207X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biophysical Chemistry 45 (1992), S. 101-108 
    ISSN: 0301-4622
    Keywords: Curved DNA ; DNA conformation ; Dynamic light scattering ; Plasmid DNA
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Fatigue & fracture of engineering materials & structures 18 (1995), S. 0 
    ISSN: 1460-2695
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Experimental determination of the fatigue endurance (S-N) curve of either a given material or a machine element imposes the choices of sample size and of stress levels to be tested. Since referenced recommendations do not apply when the data include run-outs or have variable scatter, this paper studies the confidence of fatigue tests, taking into account the effect of sample size and of a statistical model. In this research, a great number of rotary bending fatigue tests were carried out, using a heat treated carbon steel with relevant scatter of fatigue lives. The statistical analysis allowed one to obtain confidence limits of the S-N diagram estimates and to propose some criteria for a better formulation of test schedules.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Fatigue & fracture of engineering materials & structures 19 (1996), S. 0 
    ISSN: 1460-2695
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract— Modern approaches to microstructural analysis of fatigue in metallic materials consider the density and the total length per unit area of propagating surface microcracks as useful indicators of fatigue damage. Such parameters, when observed on a carbon steel studied in a previous paper, have a dispersion similar to that of fatigue life and they are linearly correlated with fatigue endurance.The aim of this paper is to extend the research on fatigue damage in the already studied carbon steel and to examine the scatter of crack propagation rate together with the evolution of surface cracks during fatigue life. The final aim of this work is to study how these two factors are correlated with fatigue life distribution in order to evaluate the effectiveness of damage detection methods.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Fatigue & fracture of engineering materials & structures 19 (1996), S. 0 
    ISSN: 1460-2695
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract— In response to the increasing structural applications in duplex steels for welded structures, fatigue behaviour of a SAF 2304 grade duplex stainless steel was investigated, considering both the base metal and GTAW welded joints. Fatigue curves and fatigue limits under rotary bending fatigue were obtained. The study focused attention on the microstructural features of fatigue crack propagation of the two series of experiments, thereby permitting an evaluation of the tortuous crack path of welded joints and the mechanisms related to threshold microstructural barriers.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    PO Box 1354, 9600 Garsington Road, Oxford OX4 2XG, UK. : Blackwell Science Ltd
    Fatigue & fracture of engineering materials & structures 28 (2005), S. 0 
    ISSN: 1460-2695
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: The most advanced structural frames of cars and motorcycles are made from welded box beams of aluminium alloys. A recent technological solution for the beams consists of press-formed metal sheets joined by welded single-lap joints. Because the frames undergo cyclic loading, the evaluation of the fatigue endurance of this kind of connections plays a crucial role in the development of the frames. The present research deals with the evaluation of the fatigue behaviour of welded lap joints, subjected to tensile and bending loads. Fractographic evidence and numerical analyses show that the fatigue strength is controlled by the presence of defects and inhomogeneities at the tip of the weld root. In particular, these defects, which appear to lie on the maximum Kθθ path, increase the stress intensity factor (SIF) at the weld root. Such an analysis, together with a statistical description of the population defects, allows us to develop a methodology to predict the fatigue strength of lap joints. A simple method for SIF computation based on finite-element (FE) analyses and structural stresses at the lap joints is then presented.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science, Ltd
    Fatigue & fracture of engineering materials & structures 26 (2003), S. 0 
    ISSN: 1460-2695
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Estimation of fatigue strength under biaxial and multiaxial loading is usually based on the assumption that fatigue limit is the limit stress for crack nucleation. However, in presence of defects and inhomogeneities the fatigue limit is determined by the threshold condition of small cracks. Nevertheless, multiaxial criteria, especially the Dang Van's criterion, could be successfully applied to defective materials. The scope of this paper is to discuss the differences in the two approaches (multiaxial criteria versus mechanics of the small cracks) for fatigue design of components containing defects subjected to biaxial and multiaxial in-phase loading. In particular it will be discussed, on the basis of the fatigue properties of large springs, the need of a correct description of the fatigue mechanism in order to determine the lower bound of fatigue strength in presence of defects.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Fatigue & fracture of engineering materials & structures 21 (1998), S. 0 
    ISSN: 1460-2695
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: A wide range of studies and experimental evidence have shown that the lower bound of fatigue properties can be correctly predicted by considering the maximum occurring defect size. The estimate of this dimension can be done by analysing the defect sizes using the statistics of extremes.The scope of this paper is to discuss and investigate the two key points in a successful application of this technique: the first is the choice of statistical method for the analysis of data; the second is the knowledge of the minimum number of defects needed to obtain a good estimate of extreme defects.The results obtained in this study allow one to formulate a procedure for estimating the extreme defects with a precision suitable for fatigue strength prediction.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Fatigue & fracture of engineering materials & structures 25 (2002), S. 0 
    ISSN: 1460-2695
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: A numerical procedure for evaluating fatigue crack closure from load-local deformation data is presented. The local compliance is assumed to vary during the entire loading cycle, including the portion when the crack is fully open. The closure mechanism-related characteristic load levels are identified based on comparisons between the open crack compliance variations upon loading and unloading. This type of compliance analysis is conditioned by an appropriate smoothness of the measured data. Hence, the choice and optimization of the procedure for smoothing of the measured data. Hence, the choice and optimization of the procedure for smoothing the recorded signals is thoroughly addressed in this paper. The performance of the algorithm is evaluated from comparisons between the computed closure parameters and their reference values which have been previously shown to correlate the observed crack growth rate behaviour.
    Type of Medium: Electronic Resource
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