ISSN:
1432-1041
Keywords:
deflazacort
;
prolactin
;
thyrotropin
;
dexamethasone
;
cortisol
;
thyrotropin releasing hormone
;
growth hormone
;
aldosterone
;
renin
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary The possible relationship between cortisol inhibition induced by deflazacort, a new glucocorticoid, and impairment of prolactin (PRL) and thyrotropin (TSH) secretion in healthy volunteers has been investigated. In 8 healthy subjects deflazacort pretreatment partly inhibited cortisol secretion but did not affect basal or TRH-stimulated secretion of PRL and TSH in comparison to placebo. After dexamethasone, there was the anticipated complete suppression of cortisol secretion, no change in PRL secretion, either in basal conditions or after TRH, and significant inhibition of the TSH response to TRH. No significant change in GH, aldosterone or renin secretion was observed after deflazacort or dexamethasone.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00547381
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