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  • 1
    Electronic Resource
    Electronic Resource
    The relation between cerebral serotonin levels and conditioned behaviour in the rat following the administration of LSD-25 and UML (1975)
    Springer
    Psychopharmacology 41 (1975), S. 245-247 
    Details
    ISSN: 1432-2072
    Keywords: LSD-25 ; UML ; Acute ; Chronic ; Behaviour ; 5-HT ; Brain ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Successive daily injections of LSD-25 and UML (1-methyl-d-lysergic acid butanolamide) caused progressive depression of brain 5-HT levels in the rat. On the fourth day, the decrease was significant with respect to the highly significant fall observed after a single administration, whereas it had been shown earlier that conditioned behaviour is no longer affected by LSD-25 after 3 days and that simultaneous administration of a single dose of LSD-25 and UML is equally ineffective in this respect. Its depression of 5-HT levels, however, has now been shown to be equal to that of LSD-25 alone at doses that influence conditioned behaviour. The findings indicate that changes in such behaviour are not dependent on brain 5-HT levels and that no link exists between such levels and the psychotomimetic effect of LSD-25 in man.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00428931
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of LSD-25 and 1-methyl-d-lysergic acid butanolamide on rat brain and platelet serotonin levels (1974)
    Springer
    Psychopharmacology 36 (1974), S. 117-122 
    Details
    ISSN: 1432-2072
    Keywords: LSD-25 ; UML ; 5-HT ; Brain ; Platelets ; Behaviour ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Factorial analysis of rat cerebral 5-HT values observed following intraperitoneal LSD-25 and UML (1-methyl-d-lysergic acid butanolamide) showed that the highly significant decrease induced by both drugs was independent of dose and that the effect of both drugs was the same. Increased platelet 5-HT values were also obtained with each drug. These findings suggest that the psychotomimetic effect of LSD-25 is not due to changes in cerebral 5-HT, since a relationship can probably be postulated between such an effect in man and the effect of LSD-25 on conditioned behaviour in the rat. It is also felt that the fact that these drugs decrease and increase cerebral and platelet values respectively may be of assistance in the interpretation of data relating to platelet 5-HT patterns in man under psychiatric conditions and during treatment with psychotropic drugs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00421783
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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