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  • 1
    Electronic Resource
    Electronic Resource
    Human adipose tissue in culture V. Studies on the metabolic effects of insulin (1976)
    Springer
    Diabetologia 12 (1976), S. 137-143 
    Details
    ISSN: 1432-0428
    Keywords: Adipose tissue ; insulin ; catecholamines ; glycolytic enzymes ; glucose
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Specimens of human adipose tissue were cultured for one week with or without the addition of insulin. The basal as well as the noradrenaline-stimulated lipolysis were enhanced in the explants cultured with insulin, showing that the long-term effect of the hormone is lipolytic. However, an acute antilipolytic effect of insulin could be demonstrated in these explants in the subsequent short-term incubations. The basal rate of glucose incorporation into the lipids was enhanced in the explants cultured with insulin. When insulin was added in the short-term incubations these explants did not further respond to the hormone while this was the case with the explants cultured without insulin. Thus, it seems that prolonged exposure to insulin leads to a diminished acute effect of the hormone on glucose metabolism. However, the same explants responded to the antilipolytic effect showing that insulin was able to bind itself to the membrane. The activities of hexokinase (HK), glucose-6-phosphate dehydrogenase (G6PDH), pyruvate kinase (PK) and lactate dehydrogenase (LDH) were increased in large fat cells both in freshly excised tissue and in the cultured explants. However, the activity of phosphofructokinase (PFK) did not correlate with the cell size. The presence of insulin during the culture period enhanced the activities of G6PDH, PK, and LDH, while this was not found for HK or PFK. The data thus suggest that the metabolic capacity of human fat cells is enhanced by long-term exposure to insulin. Although enzyme induction could be shown for G6PDH, PK and LDH it seems unlikely that this is of importance for the increased rates of glucose metabolism in these explants since the rate-limiting enzymes, HK and PFK, were not increased. Most probably, then, this stimulating effect of insulin is exerted on the membrane and the rate of glucose transport.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00428979
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  • 2
    Electronic Resource
    Electronic Resource
    Reconstruction of craniotomy burr-holes with autologous bone blugs made by a new hole-saw (1990)
    Springer
    Acta neurochirurgica 105 (1990), S. 132-134 
    Details
    ISSN: 0942-0940
    Keywords: De Martell drill ; hole-saw ; bone plugs ; Tiseel®
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A new craniotomy tool is described. The original De Martell drill was redesigned into a hole-saw for simultaneous production of burr-holes and appropriate autologous bone plugs. The plugs can easily be reinserted and locked in place using bone dust and Tiseel glue permitting appropriate healing and satisfactory cosmetic appaerance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01669996
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  • 3
    Electronic Resource
    Electronic Resource
    Mechanical and biochemical characterization of the contraction elicited by a calcium-independent myosin light chain kinase in chemically skinned smooth muscle (1985)
    Springer
    Cellular and molecular life sciences 41 (1985), S. 1002-1006 
    Details
    ISSN: 1420-9071
    Keywords: Smooth muscle ; calcium ; myosin light chain kinase ; regulation of contraction ; ATPase ; mechanics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The contraction induced by a Ca2+-independent myosin light chain kinase (MLCK-) was characterized in terms of isometric force (Fo), immediate elastic recoil (SE), unloaded shortening velocity (Vus), shortening under a constant load and ATPase activity of chemically skinned smooth muscle preparations. These parameters were compared to those measured in a Ca2+-induced contraction to assess the nature of cross bridge interaction in the MLCK-induced contraction. Fo developed in chicken gizzard fibers as well as SE were similar in contractions elicited by either agent. Vus in the contraction induced by MLCK-(0.36 mg/ml) was similar though averaged 39.3±8.9% less than Vus induced by Ca2+ (1.6x10−6M) in the control fibers. Addition of Ca2+ (1.6x10−6M) to a contraction induced by MLCK-resulted in small increases in both Fo and Vus. Shortening under a constant load was similar for both types of contractions. The contraction induced by MLCK-was accompanied by an increased rate of ATP hydrolysis. The MLCK-induced contraction is thus kinetically similar though not identical to a contraction induced by Ca2+. We conclude that with respect to actin-myosin interaction, MLCK- and Ca2+-induced contractions are similar.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01952121
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  • 4
    Electronic Resource
    Electronic Resource
    Carbon and nitrogen budgets of nematodes in arable soil (1988)
    Springer
    Biology and fertility of soils 6 (1988), S. 1-8 
    Details
    ISSN: 1432-0789
    Keywords: Barley ; Grass ; Lucerne ; Soil nematodes ; Biomass ; Respiration ; Feeding groups ; Nutrient cycling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Geosciences , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary The amounts of C and N that pass through the nematode biomass in four cropping systems, barley without and with N fertilization, grass ley and lucerne, has been estimated. The nematodes were sampled at the field site of a Swedish integrated research project “Ecology of Arable Land: The Role of Organisms in Nitrogen Cycling”. The nematode biomass was lower (200 mg dry weight m−2) in the annual (barley) than in the perennial (grass and lucerne, 350 mg dry weight m−2) crops. For respiration, the nematodes used 4–71 O2m−2 year−1 corresponding to C liberation of 1.3%–2.0% of the carbon input to the soil. A higher relative contribution by bacterial-feeding nematodes to the C and N fluxes and a higher turnover rate of the nematode biomass is an indication of more rapid nutrient circulation in the annual than in the perennial cropping systems.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00257912
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  • 5
    Electronic Resource
    Electronic Resource
    Telescopic suction tube for microsurgery (1992)
    Springer
    Acta neurochirurgica 118 (1992), S. 162-163 
    Details
    ISSN: 0942-0940
    Keywords: Suction ; telescopic suction tube ; microsurgery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An adjustable telescopic suction tube has been developed for microsurgery. Owing to this innovation, the surgeon can easily set the suction tube to a suitable length by gently pulling the end of the telescopic tube out or in.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01401302
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  • 6
    Electronic Resource
    Electronic Resource
    A New Bone Dust Packer for Use in Neurosurgery (1999)
    Springer
    Acta neurochirurgica 141 (1999), S. 183-185 
    Details
    ISSN: 0942-0940
    Keywords: Keywords: Bonedust; craniotomy; burrhole; skindent.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary  A new tool for the packing of bone dust has been developed. The instrument compresses a mixture of bone dust and saline into suitable cylindrical plugs, fitting neatly into craniotomy burrholes. The skullbone at the craniotomy area will heal neatly also assuring the best healing possibilities for the overlying skin. The cosmetic results are excellent as no skin dents or cavities will be formed over the burrholes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007010050284
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  • 7
    Electronic Resource
    Electronic Resource
    Fibrinopeptide A and fibrinogenfragment B β 15–42 and their relation to the operative trauma and post-operative thromboembolism in neurosurgical patients (1987)
    Springer
    Acta neurochirurgica 88 (1987), S. 49-55 
    Details
    ISSN: 0942-0940
    Keywords: Post operative thromboembolism ; fibrinopeptide A ; fibrinogenfragment Bβ 15–42 ; malignant cerebral tumours ; intracranial vascular disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In an earlier study on post-operative thromboembolism in neurosurgery the incidence of deep vein thromboses (DVT) diagnosed by the fibrinogen uptake test and phlebography was reduced to the same extent by two different prophylactic methods (low dose heparin or calf muscle stimulation + dextran). However, patients with lower limb paresis due to a brain lesion experienced relatively often a less successful prophylaxis compared to patients with spinal lesions. There are few reports on successful clinical methods for haematological screening of post-operative DVT. The aim of this study was to examine possible haematological indicators for postoperative thromboembolism and secondarily to elucidate whether there exist some special coagulatory or fibrinolytic characteristics in patients who had been operated upon for brain lesions. We have studied two specific coagulatory factors (FPA reflecting thrombin generation and Bβ 15–42 reflecting plasmin activity) in connection with neurosurgical operations. Patients in the above-mentioned study on post-operative DVT operated upon for malignant cerebral tumours or intracranial vascular disease exhibited postoperatively higher values for FPA compared to other neurosurgical diagnoses. B β 15–42 was higher in the malignant tumour group and almost significantly higher in the intracranial vascular group (p〈0.065). These differences could not be ascribed to the occurrence of DVT. Another 15 patients divided into a minor and a major lesion group were investigated with determination of both parameters pre- and post-operatively. Concerning FPA an increase was noticed post-operatively compared to pre-operatively in the major lesion group. B β 15–42 was higher post-operatively in this group compared to the minor lesion group. The results indicate a hyperactivity of the coagulatory system in patients with surgically treated brain parenchyma lesions. These patients are prone to develop post-operative DVT.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01400515
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  • 8
    Electronic Resource
    Electronic Resource
    The Dual-Tube Microsurgical Suction Instrument (1998)
    Springer
    Acta neurochirurgica 140 (1998), S. 1293-1295 
    Details
    ISSN: 0942-0940
    Keywords: Keywords: Suction; suction tube; microsurgery.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary  A dual-tube suction instrument intended for both macro- and microsurgery has been developed. A detachable air-tight inner tube is fitted into a conventional suction instrument; extending the ordinary sucking tube. The inner tube can easily be fitted, as well as removed from the other tube; a particular advantage in case the inner tube becomes obstructed. On removal of the inner tube the outer tube becomes cleaned and is at once, ready for re-use. Since the suction instrument does not have to be removed from the suction hose, valuable time is saved, enabling permanent sucking capacity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007010050252
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  • 9
    Electronic Resource
    Electronic Resource
    Post-operative thromboembolism in neurosurgery (1986)
    Springer
    Acta neurochirurgica 80 (1986), S. 83-89 
    Details
    ISSN: 0942-0940
    Keywords: Thromboembolism ; prophylaxis ; heparin, calf muscle stimulation ; dextran ; fibrinogen uptake test (FUT) ; phlebography ; neurosurgery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This study compares the safety and effectiveness of two methods for the prophylaxis of post-operative thromboembolism in neurosurgical patients: A: low-dose heparin (5,000 IU×2 s.c.) started preoperatively and continued daily for one week post-operatively, and B: per-operative electrical calf muscle stimulation with groups of impulses plus post-operative dextran infusions every other day for one week. Neurosurgical patients aged 40 years or more with normal laboratory coagulation values and operated under general anaesthesia were included. The 125:I-fibrinogen uptake test (FUT) was used for screening and phlebography for verification of deep venous thrombosis (DVT). 122 patients entered the study and 104 completed the prophylactic protocol, 58 in group A and 46 in group B. The two groups were comparable according to pre-operative data and distribution of diagnoses. 89 patients completed screening for post-operative DVT. We found an overall incidence of 5/49 (10 percent) DVT in group A and 5/40 (13 percent) in group B, compared to a frequency of 32–50 percent for controls without prophylaxis reported in the literature6, 16, 18. In spite of prophylaxis our patients with intracranial neoplasms and intracranial vascular disease showed a relatively higher incidence of DVT, 4/23 (17 percent) and 4/14 (29 percent) respectively, compared to patients with spinal diagnoses 2/25 (8 percent). In combination with cranial diagnoses paretic lower limbs meant an apparent risk factor, 4/7 (57 percent). However, paretic limbs appearing in cases with spinal disorders did not predetermine an unsuccessful prophylaxis, 2/14 (14 percent). Blood loss, transfusion requirements and post-operative complications did not differ significantly between the two prophylactic groups. It is concluded that both methods reduce the incidence of post-operative DVT in neurosurgical practice and that they can be used with safety. However, the basic mechanisms behind thromboembolism following parenchymatous brain lesions ought to be studied further to enable a better understanding of the thromboembolic complications and further improvement of the prophylaxis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01812279
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  • 10
    Electronic Resource
    Electronic Resource
    New microsurgical suction tubes (1990)
    Springer
    Acta neurochirurgica 104 (1990), S. 156-157 
    Details
    ISSN: 0942-0940
    Keywords: Suction ; suction tube ; microsurgery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A set of new suitable microsurgical suction tubes has been designed especially suitable for fragile and delicate tissues such as the nervous and vascular tissues in the brain and spinal cord. The set provides two different shafts and five different tubes for superficial of deep micro- as well as macro-operations. These new suction tubes have two major advantages compared to traditional suction tubes. Firstly: the perforated smooth suctiontip allows continuous suction without damage to the tissue and secondly: the tubes are quickly and easily exchanged from the suction shaft when necessary.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01842835
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