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  • 1
    Electronic Resource
    Electronic Resource
    The use of inhalational analgesia during fibre-optic colonoscopy (1971)
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 26 (1971), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.1971.tb04787.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The Disposition and Effects of Sedatives and Analgesics in Liver Disease (1978)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Medicine 29 (1978), S. 205-218 
    Details
    ISSN: 0066-4219
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.me.29.020178.001225
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Amphotericin-b nephrotoxicity in humans decreased by sodium supplements with coadministration of ticarcillin or intravenous saline (1987)
    Springer
    Journal of molecular medicine 65 (1987), S. 500-506 
    Details
    ISSN: 1432-1440
    Keywords: Amphotericin B ; Nephrotoxicity ; NaCl loading ; Renal insufficiency
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Previous observations suggest that salt loading can help reverse amphotericin-B induced nephrotoxicity. Evidence is presented indicating that sodium supplements provide prophylaxis against the development of amphotericin-B nephrotoxicity. In a retrospective study at Vanderbilt University, 14/21 patients receiving amphotericin B (target dose, 25 mg/day) without salt supplements developed impaired renal function; in 10 instances amphotericin B was temporarily withdrawn. In contrast, only 2/17 patients who received amphotericin B with ticarcillin (with its obligatory sodium supplement) developed nephrotoxicity (P〈0.01). All four patients, who were receiving the combination of amphotericin B and ticarcillin and who had their ticarcillin therapy stopped, developed nephrotoxicity in the subsequent week. In a prospective observational study at Essen, 20 patients had 24 courses of amphotericin B (target dose, 40 mg/day) with routine supplementation of 1 liter of 0.9% sodium chloride daily. Only two patients showed evidence of nephrotoxicity and no dosage modification of amphotericin B was required in any patient. Four patients with initial evidence of mildly impaired renal function received full supplements without adverse effects or the development of nephrotoxicity. These observations suggest that routine parenteral administration of sodium supplements can help minimize the nephrotoxic potential of amphotericin B.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01721035
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Attenuation of cisplatinum-induced nephrotoxicity in the rat by high salt diet, furosemide and acetazolamide (1985)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 329 (1985), S. 201-205 
    Details
    ISSN: 1432-1912
    Keywords: Cisplatinum ; Nephrotoxicity ; Furosemide ; Acetazolmide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The influence of variations in sodium chloride diet, furosemide and acetazolamide on nephrotoxicity induced by cisplatinum have been investigated in the rat by measuring serum creatinine concentrations 5 days after cisplatinum (5 mg/kg, ip) administration. Sodium chloride depletion enhanced, while sodium chloride loading minimized changes in renal function. Increases in urine flow rate following a dextrose water load failed to alter the nephrotoxic response. Both furosemide and acetazolamide, given 30 min before cisplatinum, attenuated the nephrotoxic response. In contrast, neither sodium chloride loading, furosemide, nor acetazolamide influenced the change in renal function when given 30 min after cisplatinum. These observations indicate that renal damage due to cisplatinum can be modified by alterations in dietary salt and by diuretics and that the extent of ultimate renal damage is dependent on factors occurring immediately after cisplatinum administration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00501213
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Pharmacokinetics after a single oral dose of bopindolol in patients with cirrhosis (1990)
    Springer
    European journal of clinical pharmacology 39 (1990), S. 569-572 
    Details
    ISSN: 1432-1041
    Keywords: Bopindolol ; cirrhosis ; antipyrine ; pharmacokinetics ; side effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The plasma concentration-time curve of the hydrolysis product of bopindolol has been investigated in 14 patients with cirrhosis and in 15 healthy volunteers given a single oral dose of 2 mg bopindolol. Cirrhosis was confirmed by history and clinical examination or liver biopsy. The time to maximum concentration, maximum concentration and AUC of hydrolyzed bopindolol were similar in the patients and controls. However, the elimination half-life was 6.0 h in controls and 9.5 h in cirrhotics. Antipyrine clearance was markedly decreased in patients with cirrhosis, but no correlation was found with the pharmacokinetic parameters of hydrolysed bopindolol. Although the AUC was not significantly altered in patients with cirrhosis, the longer half-life of hydrolysed bopindolol suggests impairment of its disposition in liver disease, which could lead to significant accumulation of drug during chronic dosing.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00316097
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    Paper (German National Licenses)
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