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  • 1
    Electronic Resource
    Electronic Resource
    Propranolol steady-state pharmacokinetics are unaltered by omeprazole (1987)
    Springer
    European journal of clinical pharmacology 33 (1987), S. 369-373 
    Details
    ISSN: 1432-1041
    Keywords: propranolol ; omeprazole ; pharmacokinetics ; drug interaction ; healthy volunteers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In a randomised double-blind cross-over study, 8 normal subjects received propranolol 80 mg twice daily with omeprazole 20 mg or identical placebo each morning. Propranolol kinetics were measured on day 8 of both treatment periods. Areas under the propranolol concentration/time curves were not significantly increased by omeprazole treatment: off treatment mean 787.6, on treatment 802.5 ng−1·ml·h. Maximum and minimum steady-state propranolol concentrations were similarily unaffected. Omeprazole also failed to increase the clinical effect of propranolol, as assessed by exercise tests on Day 8 of treatment. We conclude that omeprazole in the dose likely to be used for peptic ulcer has no significant effect on the kinetics or action of propranolol.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00637632
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  • 2
    Electronic Resource
    Electronic Resource
    OMEPRAZOLE: EFFECTS ON OXIDATIVE DRUG METABOLISM IN THE RAT (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 13 (1986), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. Omeprazole, a substituted benzimidazole and a potent gastric antisecretory drug has been tested for inhibition of microsomal drug oxidative function in the rat.2. A single dose of 40 mg/kg prolonged pentobarbitone sleeping times from 118 (range 73–168) min to 195 (159–222) min (P 〈 0.01), pentobarbitone half-lives from 89 (63–114) to 112 (54–146) min (P 〈 0.05) and aminopyrine breath 14CO2 half-lives from 43 (37–51) to 56 (49–79) min (P 〈 0.05). Omeprazole in doses of 20 mg/kg or less had no significant effect.3. In prolonging pentobarbitone sleeping times omeprazole 40 mg/kg and an equimolar (30 mg/kg) dose of cimetidine were approximately equipotent.4. These results contrast with studies in man in which much smaller doses of omeprazole have been shown to produce clinically significant inhibition of drug metabolism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1986.tb00916.x
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  • 3
    Electronic Resource
    Electronic Resource
    ENZYME INDUCTION BY EATING CHARCOAL-GRILLED STEAK WITH NO EFFECT ON BLOOD LIPIDS (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 16 (1989), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. There has been interest in the suggestion that enzyme-inducing drugs, such as anticonvulsants, may produce beneficial changes in lipoprotein levels, in particular a rise in the ratio of high density lipoprotein cholesterol to total cholesterol.2. This controlled study observed the effects of diets of charcoal or oven-cooked beef on antipyrine clearance (a commonly used measure of drug metabolizing capacity), the apparent oral clearance of phenacetin (a measure of cytochrome P448-dependent enzyme activity) and blood lipids in 18 healthy volunteers.3. Charcoal-cooked beef increased antipyrine clearance by an average of 20% (P 〈 0.059) and increased the apparent oral clearance of phenacetin fivefold (P 〈 0.01). In contrast, oven-cooked beef did not significantly alter either measure of microsomal function. Neither diet had any effects on blood lipids.4. We conclude that the type and degree of enzyme induction achieved by this type of dietary manipulation does not produce beneficial changes in lipoprotein profiles. A previously noted rise in high density lipoprotein cholesterol levels in volunteers fed charcoal-cooked beef may have been due to the effects of charcoal formed by charring of the beef during cooking.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1989.tb01516.x
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  • 4
    Electronic Resource
    Electronic Resource
    PLASMA CATECHOLAMINE CONCENTRATIONS DURING MORPHINE WITHDRAWAL IN CONSCIOUS GUINEA-PIGS (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 14 (1987), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. Plasma noradrenaline (NA) and adrenaline (AD) concentrations and locomotor activity were measured in conscious normal and adrenalectomized guinea-pigs before and after injection of a single dose of morphine (15 mg/kg) and following precipitation of withdrawal with naloxone 2 h later. Arterial blood samples were obtained via carotid catheters inserted 3 days before experiment. Normal guinea-pigs given saline instead of morphine were used as controls.2. Increased locomotor activity occurred following naloxone injection in both intact and adrenalectomized morphine-treated guinea-pigs.3. Plasma AD concentration was significantly elevated only during the naloxone- precipitated withdrawal period, whereas plasma NA concentration was also elevated during the morphine treatment period. No significant changes occurred in saline-treated guinea-pigs given naloxone.4. In adrenalectomized guinea-pigs AD did not reach detectable levels in the plasma at any time during the experiments, thus showing that the increased plasma AD level during morphine withdrawal in normal animals reflected adrenal medullary release.5. It was concluded that measurements of plasma AD concentration and locomotor activity in guinea-pigs should be useful for the study of the interactions between behavioural and autonomic mechanisms involved in opiate dependence and withdrawal, since the effects of morphine and morphine withdrawal on the autonomic nervous system are clearly different in this species.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1987.tb01883.x
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  • 5
    Electronic Resource
    Electronic Resource
    Magnetic properties of P-type GaMnP grown by molecular-beam epitaxy (2001)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 79 (2001), S. 3128-3130 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Growth by molecular-beam epitaxy of the dilute magnetic alloy GaMnP:C is reported. The GaMnP:C contains 9.4% Mn as determined by Auger electron spectroscopy, and is single phase as determined by x-ray diffraction, reflection high-energy electron diffraction, and transmission electron microscopy. Both magnetization and magnetotransport data are reported. The results show the anomalous Hall effect, negative magnetoresistance, and magnetic hysteresis at 10 K, indicating that Mn is incorporating into the GaP:C and forming the ferromagnetic semiconductor GaMnP:C. Temperature-dependent magnetization and anomalous Hall data show that magnetic behavior persists to at least 200 K, which is a very high value for a III–V based dilute magnetic semiconductor. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1416472
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  • 6
    Electronic Resource
    Electronic Resource
    An estimate of the juvenile sulfur content of basalt (1971)
    Springer
    Contributions to mineralogy and petrology 33 (1971), S. 118-127 
    Details
    ISSN: 1432-0967
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract Sulfur analyses by X-ray fluorescence give an average content of 107 ppm for 9 samples of fresh subaerially-erupted oceanic basalt and 680 ppm for 38 samples of submarine erupted basalt. This difference is the result of retention of sulfur in basalt quenched on the sea floor and loss of sulfur in basalt by degassing at the surface. The outer glassy part of submarine erupted basalt contains 800±150 ppm sulfur, and this amount is regarded as an estimate of the juvenile sulfur content of the basalt melt from the mantle. The slower cooled interiors of basalt pillows are depleted relative to the rims owing to degassing and escape through surface fractures. Available samples of deep-sea basalts do not indicate a difference in original sulfur content between low-K tholeiite, Hawaiian tholeiite, and alkali basalt. The H2O/S ratio of analyzed volcanic gases is generally lower than the H2O/S ratio of gases presumed lost from surface lavas as determined by chemical differences between pillow rims and surface lavas. This enrichment of volcanic gases in sulfur relative to water may result from a greater degassing of sulfur relative to water from shallow intrusive bodies beneath the volcano.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00386110
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  • 7
    Electronic Resource
    Electronic Resource
    Brief report: Validation of the autism reinforcer checklist for children (1984)
    Springer
    Journal of autism and developmental disorders 14 (1984), S. 429-433 
    Details
    ISSN: 1573-3432
    Source: Springer Online Journal Archives 1860-2000
    Topics: Psychology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02409833
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