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  • 1
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Pharmacology 45 (2005), S. 203-226 
    ISSN: 0362-1642
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Chemistry and Pharmacology
    Notes: Botanicals such as herbal products (HPs) and nutraceuticals (NCs) are often regarded as low risk because of their long history of human use. Anecdotal and literature reports of adverse drug events (ADEs) and clinical studies with HPs are increasing, but many of the reports are incomplete and contradictory. These reports need to identify confounding factors and explain contradictory findings if they are to help health care professionals or patients understand what risks are involved. HPs are complex botanicals, not single-active ingredient (SAI) products. Studies can be confounded by different manufacturing processes and formulations, including cosmetics and food supplements; environment; chemotypes; misidentification or adulteration; and factors associated with the patient or user population such as use, total drug load, and genetics. Future studies need to be conducted with characterized product that includes all commercially available related products. Clinical trials should be relevant to the user population and take into account the confounding factors that may influence the interpretation of the findings.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1573-5060
    Keywords: condensed tannins ; field pea ; grass pea ; Pisum sativum L. ; Lathyrus sativus L. ; total phenolics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract Seed samples of seventeen field pea cultivars grown at five locations, and nine grass pea lines grown at two locations, in western Canada during 1993 and 1994 were analysed for total phenolics and condensed tannins. Each location in each year was considered as one environment. Total phenolics in field pea differed significantly among cultivars, ranging from 162 mg/kg DM (dry matter) (CE, catechin equivalents) for AC Tamor to 325 mg/kg DM (CE) for Richmond. Field pea had barely detectable levels of condensed tannins. Total phenolics in grass pea ranged from 868 mg/kg DM (CE) for L880388 to 2059 mg/kg DM (CE) for LS89110. Condensed tannins in grass pea ranged from 0.89 g/kg DM (CE) for L880388 to 5.18 g/kg DM (CE) for LS89125. Cultivar had a larger relative contribution to total phenolic levels in field pea and to total phenolic and condensed tannin levels in grass pea than environment. Total phenolic and condensed tannin levels were not correlated with seed yield and seed protein content in field pea or grass pea. Levels of total phenolics and condensed tannins were positively correlated in grass pea. Grass pea seeds with darker seed coat colour contained higher levels of condensed tannins.
    Type of Medium: Electronic Resource
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