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  • 1
    Electronic Resource
    Electronic Resource
    Temporal prominence of auditory evoked potentials (N1 wave) in 4-8-year-old children (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Psychophysiology 34 (1997), S. 0 
    Details
    ISSN: 1469-8986
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Psychology
    Notes: Cortical auditory evoked potentials (N1 wave) were studied in 24 adults (12 men, 12 women) and 20 children (12 boys, 8 girls; age: 4-8 years). In adults, this wave was recorded with maximal amplitude at frontocentral sites, peaking at about 100 ms poststimulation, whereas in children the auditory response displayed maximal amplitude at the midtemporal sites, with a positive wave at about 100 ms and a large negative wave at approximately 170 ms. Moreover, the modulatory effects of intensity on N1 amplitude were prominent at frontocentral sites in adults and at temporal sites in children. Frontocentral negative response was also recorded in children but was smaller in amplitude and longer in peak latency (around 140 ms) than in adults; responses were of greater amplitude at the frontal site than at the vertex before 6 years of age, whereas the reverse was more often found after this age. These data suggest great differences with age in the neural generators contributing to auditory evoked potentials recorded in the N1 latency range.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1469-8986.1997.tb02413.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The Topography of Event-Related Slow Potentials During Reflex Movement (Ankle Jerk) Conditioning (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Psychophysiology 19 (1982), S. 0 
    Details
    ISSN: 1469-8986
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Psychology
    Notes: The morphology and scalp distribution of slow negative potentials elicited in type I conditioning, requiring no instruction, were studied. The paradigm involved the presentation of a conditioned stimulus (S1), followed 1500 msec later by an unconditioned stimulus (H), the electrical stimulation of the popliteal nerve evoking an ankle jerk (Hoffmann reflex).Our topographical data showed that two components develop in the interstimulus interval S1-H: a large fronto-central early component followed by a late centro-parietal negative component which precedes the H-reflex movement. This negative shift terminates abruptly in a positivity post-H-reflex.These anticipatory components show similarities, particularly at the parietal site, to slow waves elicited in a CNV paradigm involving the presentation of an indicative stimulus (S1) followed by an imperative stimulus (S2) requiring an operant motor response.These results are discussed in terms of conditioning, arousal, and early preparatory and time estimation processes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1469-8986.1982.tb02493.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    A dark-light emergence test: Study at two times of the nycthemeral cycle in four-and twelve-week-old rats
    Amsterdam : Elsevier
    Behavioural Processes 5 (1980), S. 281-285 
    Details
    ISSN: 0376-6357
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Psychology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0376-6357(80)90008-X
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Peripheral auditory asymmetry in infantile autism (2001)
    Oxford, UK : Blackwell Science Ltd
    European journal of neuroscience 13 (2001), S. 0 
    Details
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Difficulty in filtering relevant auditory information in background noise is one of the features of autism. Auditory filtering processes can be investigated at the peripheral level as they are hypothesized to involve active cochlear mechanisms which are regulated by the efferent activity of the medial olivocochlear (MOC) system. The aim of the present work was therefore to assess these peripheral auditory processes in 22 children and adolescents with autism compared with age- and gender-matched normal controls. Active cochlear mechanisms were evaluated with transiently evoked otoacoustic emissions (TEOAEs) and MOC system efficiency was assessed via TEOAEs which are decreased when stimulating the contralateral ear with noise. The MOC system evaluation was performed on 18 of the 22 children. In both studies, results were analysed according to age (from 4 to 10 years and from 11 to 20 years). The main result concerns the asymmetry of the efferent system which differs in individuals with autism. Several neural processes might be hypothesized as involved in the results obtained as the MOC system which originates in the brainstem received regulating controls from upper brain structures including auditory cortex. Lateralization abnormalities at the auditory periphery may reflect indirectly a problem at a higher level of auditory processing. A second important result shows a decrease in TEOAE amplitude with age, in patients, that may correspond to a decrease in hearing sensitivity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1460-9568.2001.01423.x
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Dynamic blood flow modifications and electrophysiological responses to auditory stimulations in children
    Amsterdam : Elsevier
    International Journal of Psychophysiology 14 (1993), S. 116 
    Details
    ISSN: 0167-8760
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine , Psychology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0167-8760(93)90132-9
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Urinary dopamine metabolites as indicators of the responsiveness to fenfluramine treatment in children with autistic behavior (1989)
    Springer
    Journal of autism and developmental disorders 19 (1989), S. 241-254 
    Details
    ISSN: 1573-3432
    Source: Springer Online Journal Archives 1860-2000
    Topics: Psychology
    Notes: Abstract Modifications in serotonin and dopamine metabolism were evaluated in 13 children with autistic behavior and related to their responsiveness to fenfluramine treatment. A double-blind medication-placebo crossover design was used. Each patient received 1.5 mg/kg fenfluramine daily for 3 months followed and preceded by placebo for 1 month. Clinical improvement was observed in 6 children (responders). It included reduction of behavioral symptoms such as motor activity, anxiety, mood disturbances, and distractibility. Modifications of serotonin (5-HT), dopamine (DA), and DA metabolites [homovanillic acid (HVA) and dihydroxyphenylacetic acid (DOPAC)] were assessed at urinary levels. Responders and nonresponders showed a significant decrease of urinary 5-HT levels on fenfluramine. The main differences between the two groups of subjects were found with HVA, the major metabolite of DA. Fenfluramine significantly increased HVA levels in responders whereas no significant modification was found in nonresponders. Moreover the initial level of HVA (lower in responders) significantly differentiated the two groups. These results suggest that the clinical response to fenfluramine could be related to the dopaminergic action of this drug and that urinary DA metabolite levels could be considered as indicators of the responsiveness to fenfluramine treatment in children with autistic behavior.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02211844
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Urinary free and conjugated catecholamines and metabolites in autistic children (1988)
    Springer
    Journal of autism and developmental disorders 18 (1988), S. 583-591 
    Details
    ISSN: 1573-3432
    Source: Springer Online Journal Archives 1860-2000
    Topics: Psychology
    Notes: Abstract Urinary catecholamines (DA, NE, E) and their main metabolites (HVA, DOPAC, MHPG) were analyzed both as free and conjugates in eight children diagnosed as autistic according to DSM-III criteria and eight normal children. Significant differences appeared for the urinary excretion of both DA and NE and their respective metabolites: Autistic children showed low DA, high HVA, high NE, low MHPG urinary levels. These results are consistent with previous findings on altered catecholamine metabolism in autistic children. They suggest that autistic behaviour might be related to an abnormal functional imbalance among monoamines either at a molecular level or at a system level. Furthermore, they emphasize the special interest of urinary assays in pediatric research.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02211876
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    Paper (German National Licenses)
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