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  • 1
    Electronic Resource
    Electronic Resource
    Investigation of the acute toxicity of some trimethyl and triethyl phosphorothioates with particular reference to those causing lung damage (1982)
    Springer
    Archives of toxicology 51 (1982), S. 221-231 
    Details
    ISSN: 1432-0738
    Keywords: Trimethylphosphorothioates ; Triethylphosphorothioates ; Rat ; LD50 ; Lung damage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The acute toxicity of trimethyl and triethylphosphorothioates present as impurities in technical organophosphorus insecticides has been examined in rats. Although the majority of these compounds caused cholinergic signs, in some a second phase of toxicity affecting the lung was also seen. Rats after recovering from the cholinergic phase of poisoning showed respiratory distress and died 3–6 days after dosing with a massive increase in lung weight, associated with progressive diffuse interstitial thickening maximal on day 4. For two compounds no cholinergic toxicity was observed and narcosis was the predominant sign of poisoning. Pretreatment with phenobarbitone, piperonyl butoxide or SKF525A protected rats against lung toxicity caused by trimethylphosphorothioate and dithioate but only phenobarbitone was effective against OOS-triethylphosphorothioate lung toxicity. Direct intrabronchial instillation of OSS-trimethylphosphorodithioate and OOS-triethylphosphorothioate, both of which had been shown to cause lung damage after other routes of dosing, did not greatly increase the toxicity of these two compounds, suggesting that they are not directly toxic to the lung and probably require metabolism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00348854
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Environmental Carcinogens (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 534 (1988), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1988.tb30091.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Cellular responses to trialkylphosphorothioate-induced injury in rat lung (1982)
    Springer
    Archives of toxicology 51 (1982), S. 79-89 
    Details
    ISSN: 1432-0738
    Keywords: Trialkylphosphorothioates ; Rat ; Lung ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Various trialkylphosphorothioates occur as impurities in many organophosphorus pesticides. In addition to the immediate, cholinergic symptoms usually associated with the toxicity of organophosphorus compounds an oral LD50 dose of O,S,S-trimethyl phosphorodithioate or O,O,S-triethyl phosphorothioate to rats, resulted in the delayed development of lung lesions and often death within 4 days. This study attributes the late crisis to impaired lung function resulting from massive alveolar oedema and cellular responses to the selective destruction of type I pneumocytes. Proliferation of type II pneumocytes produced an epithelium of very large cells which resulted in a thick blood/alveolus barrier and also occluded much of the alveolar lumen. Debris from the type I pneumocytes was liberated into the alveolar lumen resulting in leukocytic infiltration of the interstitial tissue and an increase in the number of alveolar macrophages. The lung morphology of animals surviving the crisis period returned to normal within a further 4 days with the transformation of many hypertrophic type II pneumocytes into type I alveolar lining cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00279323
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  • 4
    Electronic Resource
    Electronic Resource
    Carcinogenic activity of hexacholorobenzene in hamsters (1977)
    [s.l.] : Nature Publishing Group
    Nature 269 (1977), S. 510-511 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Six-week-old Syrian golden hamsters from the Eppley colony were used. They were fed ad libitum for life a diet containing 50, 100 and 200 parts per million (p.p.m.) HCB. The HCB was more than 99.5% pure (BDH, England). Dosage regime and experimental design are shown in Table 1. At 50 weeks of age, ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/269510a0
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    Paper (German National Licenses)
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