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  • 1
    Electronic Resource
    Electronic Resource
    Multidrug resistance-associated protein (MRP1) gene is strongly expressed in gastric carcinomas. Analysis by immunohistochemistry and real-time quantitative RT-PCR (2005)
    Oxford, UK : Blackwell Science Ltd
    Histopathology 46 (2005), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aims : To assess MRP1 protein and MRP1 mRNA levels in gastric carcinomas and in non-neoplastic mucosa remote from the tumours. MRP1 gene expression may play a role in the complex pattern of chemoresistance present in gastric carcinomas.Methods and results : A total of 57 carcinomas and respective gastric tissues were included for immunohistochemical assessment with the anti-MRP1 monoclonal antibodies MRPr1 and QCRL-1. Of these, 35 tumour and gastric mucosa tissues were also assessed by real-time quantitative reverse transcriptase-polymerase chain reaction. Medium or high MRP1 protein expression was detected in 89% and 77% of carcinomas and in 96% and 93% of non-neoplastic gastric mucosa by MRPr1and QCRL-1, respectively. No difference in MRP1 mRNA levels was detected between carcinomas and non-neoplastic gastric mucosa tissues in 77% of the patients. A significant correlation was found between MRP1 mRNA level and protein expression detected in carcinomas related to non-neoplastic gastric mucosa, although they were non-concordant in 29% of the patients.Conclusions : MRP1 gene is usually expressed in most gastric carcinomas and does not differ substantially from that observed in non-neoplastic gastric mucosa remote from the tumour. However, a decrease in MRP1 gene expression is found in some carcinomas. For accurate assessment of changes in MRP1 expression between tumour and normal tissues both protein and mRNA detection are necessary.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.2005.02100.x
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  • 2
    Electronic Resource
    Electronic Resource
    Perianal disease of tuberculous origin (1999)
    Springer
    Diseases of the colon & rectum 42 (1999), S. 110-112 
    Details
    ISSN: 1530-0358
    Keywords: Perianal tuberculosis ; Perianal ulcers ; Extrapulmonary tuberculosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract PURPOSE: A case of anal tuberculosis in an otherwise asymptomatic patient with bleeding anal ulcers is presented. The clinical features of this entity and the problems in differential diagnosis between anal infectiousvs. inflammatory diseases are discussed. METHODS: The management and outcome of the case of an adult patient who presented with perianal ulcers is described. RESULTS: On a three-drug antituberculous regimen, symptoms abated, radiographic infiltrates improved, and perianal ulcers healed. CONCLUSION: Anal tuberculosis is an extremely rare disease. A tuberculous origin must be considered when the cause of perianal ulcers is unclear to avoid undesirable delays in the diagnosis and treatment of this disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02235192
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    92. Kombinierte Ein- und Abflußkatheter als Spül-Saugdrainage (1980)
    Springer
    Langenbeck's archives of surgery 352 (1980), S. 323-323 
    Details
    ISSN: 1435-2451
    Keywords: Anastomotic leak ; Peritonitis ; Peritoneal lavage ; Postoperative Fistel ; Peritonitis ; Peritoneallavage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Das Mißachten der Verlagerungsdynamik der Peritonealflüssigkeit und der frühzeitige Funktionsverlust der Drains sind die häufigsten Ursachen für die Uneffektivität der peritonealen Spülung. Spül Saugdrainagen müssen nach den Verlagerungsprinzipien der Peritonealflüssigkeit, an den bevorzugten Entstehungsstellen von Fisteln bzw. Abscessen in ausreichender Zahl gelegt werden. Mit unserem selbstangefertigten kombinierten Ein- und Abflußkatheter wird eine effektive Dauerspülung von Fisteln bzw. Absceßhöhlen erzielt.
    Notes: Summary Cleansing of the peritoneal area is mot frequently unsuccessful because of failure to take into account (1) the mechanism of the system of fluid movement in the peritoneum and (2) premature malfunctioning of the drainage tubes. Sufficient drainage tubes for irrigation-aspiration should be situated in the areas most suitable for fistulas or abscesses, bearing in mind the movement systems of intraperitoneal fluids. By means of catheter expressly made for combined irrigation-aspiration, the enteric fistulas and isolated abscesses can be effectively cleansed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01292053
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    Paper (German National Licenses)
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