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  • 1
    Electronic Resource
    Electronic Resource
    Somatostatin, anaesthesia, and the carcinoid syndrome (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 42 (1987), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A patient with carcinoid syndrome on long-term antiserotonin therapy with parachlorophenylalanine, experienced a flushing attack with hypotension during the prophylactic administration of aprotonin prior to the induction of anaesthesia. When she was subsequently prepared with a long-acting somatostatin analogue, octreotide (Sandostatin, Sandoz SMS 201–995), plasma levels of tumour-released hormones were reduced and anaesthesia for resection of hepatic metastases was uneventful. The advantages of an anaesthetic approach based on inhibition of carcinoid tumour activity, rather than antagonism of released hormones, are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.1987.tb03087.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Pathology of hepatic peroxisomes and mitochondria in patients with peroxisomal disorders (1990)
    Springer
    Virchows Archiv 416 (1990), S. 255-264 
    Details
    ISSN: 1432-2307
    Keywords: Peroxisomes ; Peroxisomal disorders ; Neonatal adrenoleukodystrophy ; Infantile Refsum's disease ; Pseudo-Zellweger disease ; Mitochondria
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The morphology of hepatic peroxisomes in five patients with metabolic disorders believed to be due to inherited defects of peroxisomal function or biogenesis is described. Electron microscopy and cytochemical staining for catalase were used to identify peroxisomes in two boys with infantile Refsum's disease (IRD), a girl with autopsy confirmed neonatal adrenoleukodystrophy (NALD), and two boys with pseudo-Zellweger syndrome (PZS). In the patients with IRD and NALD hepatic peroxisomes were significantly reduced in size and number and contained electron dense centres. In the liver of the patients with PZS the peroxisomes were enlarged. Morphologically abnormal peroxisomes were also detected in autopsy tissue from one boy with PZS using electron microscopy. Lamellar-lipid inclusions and mitochondria with crystalline inclusions and/or abnormal cristae are also described in two patients, one with IRD, the other with NALD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01678985
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Online patient-monitoring system for the simultaneous analysis of blood K+, Ca2+, Na+ and pH using a quadruple-function ChemFET integrated-circuit sensor (1985)
    Springer
    Medical & biological engineering & computing 23 (1985), S. 329-338 
    Details
    ISSN: 1741-0444
    Keywords: Blood electrolytes ; Calcium ; Chem FET ; Ion-selective electrodes ; ISFET ; Online monitoring ; Patient monitoring ; pH ; Potassium ; Sodium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract A system for the online, simultaneous analysis of bloodK +,Ca 2+,Na + andpH using a quadruple-function ChemFET integrated circuit sensor is described. The ChemFET device is mounted into a miniature flow-through cell having a very small sample volume (ca. 30 μl), which is incorporated into a sensing unit together with a pinch-tube sampling valve, a heat exchanger and a reference electrode. The sensing unit is small and robust, with an overall input deadspace small enough (ca 460 μl) to permit connection directly to an indwelling, dual-lumen cannula for continual, intermittent sampling without causing undue exanguination; the cannula is actively heparinised to prevent clot formation in the aspirated blood samples. An analyte-chopping analysis (ACA) system is used to prevent protein contamination of the ChemFET sensor, and to ensure the high precision of measurement which is necessary for clinical applications over extended periods. The system is controlled by a microcomputer, which supervises preusage calibration, logs data, and provides graphical displays of ion concentrations. Preliminary clinical results are presented which reveal significant dynamic changes inCa 2+ due to the intraoperative transfusion of citrated blood, and substantial fluctuations in the concentration profiles ofK +,Ca 2+ andpH during cardiopulmonary bypass.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02441586
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    Paper (German National Licenses)
    Fulltext
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