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  • 1
    Electronic Resource
    Electronic Resource
    Biochemical features and inhibitors of the 1-aminocyclopropane-1-carboxylic acid oxidase isolated from pear fruit (2000)
    Springer
    European food research and technology 210 (2000), S. 397-401 
    Details
    ISSN: 1438-2385
    Keywords: Key words 1-Aminocyclopropane-1-carboxylic acid oxidase ; In vitro activity ; Inhibitors ; Ethylene ; Pear (Pyrus communis L.)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract  1-Aminocyclopropane-1-carboxylic acid (ACC) oxidase, the enzyme that catalyzes the final step in ethylene biosynthesis, was recovered from pear (Pyrus communis L. cv. Blanquilla) fruit tissues with maximum activity at pH 6.5. The enzyme eluted as a single hydrophobic protein with an estimated molecular weight of 37.9 kDa in a three-step FPLC chromatographic procedure. The sensitivity of the pear ACC oxidase against a range of chemicals known by their inhibitory action on ethylene biosynthesis in vivo has been studied. Among them, and in contrast to a previous proposal, α-(p-chlorophenoxy)isobutyric acid, a substance possessing antiauxin properties, did not inhibit the in vitro enzyme activity. The significance of the results is discussed in terms of the nature and mechanism of the enzyme reaction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002170050570
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  • 2
    Electronic Resource
    Electronic Resource
    Synthesis and mode(s) of action of a new series of imide derivatives of 3-nitro-1,8 naphthalic acid (1980)
    Springer
    Cancer chemotherapy and pharmacology 4 (1980), S. 61-66 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Four new imide derivatives of 3-nitro-1,8-naphthalic acid have been synthesised. The compounds show strong cytostatic activity against both HeLa and KB cells and are moderately toxic towards both mice and rats (LD50 above 4 mg/kg IP). Two of the most active compounds, M-4212 and M-12210, prevented the development of mouse Ehrlich ascites and rat Yoshida carcinoma. All these drugs block cell growth by inhibiting the synthesis of both DNA and RNA. In particular, both M-4212 and M-12210 raise the melting point of double-stranded DNA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00255461
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  • 3
    Electronic Resource
    Electronic Resource
    Longitudinal Overgrowth of Bone After Osteotomy in Young Rats: Influence of Bone Stability (1997)
    Springer
    Calcified tissue international 60 (1997), S. 391 -393 
    Details
    ISSN: 1432-0827
    Keywords: Key words: Bone growth — Fractures — Osteotomy.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract. One hundred and five 5-week-old male rats were used to study the influence of the stability of an osteotomy on longitudinal overgrowth of the bone. In 45 rats (Group 1) a transverse diaphyseal osteotomy of the right tibia was made; the left tibia was left untreated. In the second 45 rats (Group 2) the right tibia was osteotomized after applying an external fixator; the left tibia underwent a sham operation without osteotomy. Fifteen further rats (Group 3) were used as a nonoperated control group. After being measured at different periods up to 20 weeks, the osteotomized tibiae of the Group 1 (unstable) were 16–25% longer than those of their nontreated limbs (P 〈 0.001). The osteotomized tibiae of the Group 2 (stable) were 6–11% longer than those of the sham-operated opposite limbs (P 〈 0.001). The osteotomized and unstable tibiae were 9–17% longer than the osteotomized and stable tibiae (P 〈 0.001) throughout the whole study. Although several factors have been considered to be responsible for longitudinal bone overgrowth after fracture in young animals, this work suggests that bone's stability plays a decisive role in the final outcome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002239900249
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  • 4
    Electronic Resource
    Electronic Resource
    Cyclosporin A versus methotrexate, followed by rescue with folinic acid as prophylaxis of acute graft-versus-host disease after bone marrow transplantation (1989)
    Springer
    Annals of hematology 58 (1989), S. 63-68 
    Details
    ISSN: 1432-0584
    Keywords: Prophylaxis for acute GVHD ; Cyclosporin A ; MTX + folinic acid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Fifty-seven patients undergoing bone marrow transplantation were randomly assigned to receive either cyclosporin A (CsA, n=26) or methotrexate, followed by rescue with folinic acid (MTX + FA, n=31) as prophylaxis for graft-versus-host disease (GVHD). All patients but one receiving CsA had evidence of sustained engraftment, and there was no difference between the two groups on the day in which marrow engraftment was documented. Oropharyngeal mucositis was of similar incidence and severity in the two groups. In contrast, patients receiving CsA showed higher renal and hepatic toxicity rates than those treated with MTX + FA. Severe-to-moderate acute GVHD (grades II–IV) was documented in 12 patients receiving CsA and in 12 treated with MTX + FA. The cumulative incidence of this complication was similar in both groups (46.1% and 38.7%). Similarly, there was no difference in the incidence of chronic GVHD. The leukemic relapse rates were also comparable, as well as the estimated probability of survival, which was 55% in patients treated with MTX + FA and 41% in those who were given CsA. We conclude that MTX + FA is as effective as CsA in the prevention of GVHD, with the additional advantage of reduced renal and hepatic toxicities.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00320650
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    Paper (German National Licenses)
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