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  • 1
    Electronic Resource
    Electronic Resource
    The distribution of native albumin and foreign albumin injected into lateral ventricles of prenatal and neonatal rat forebrains (1985)
    Springer
    Anatomy and embryology 172 (1985), S. 345-351 
    Details
    ISSN: 1432-0568
    Keywords: Rat ; Developing forebrain ; Immunocytochemistry ; Albumin ; Uptake
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Several plasma proteins are found within the cells of the developing brain of many species, with a distribution pattern which changes during development, but the origin of such proteins is in dispute. The experiments described here were designed to test the hypothesis that some developing brain cells are able to take up plasma proteins. The distribution of the plasma protein albumin has been studied in the rat forebrain from the 14th day of gestation until birth. Although present within the cerebrospinal fluid and plasma from the earliest age studied, albumin was not seen within cells of the developing forebrain until day 16E or 17E. A foreign protein, sheep albumin, was injected into the ventricles at days 14E, 16E, 18E, 20E and on the day of birth. Sheep albumin can be detected in the presence of rat albumin because the antibody to sheep albumin does not cross-react with rat albumin. The sheep albumin was taken up very rapidly into cells of the ventricular zone at the later but not the earlier ages, thus mimicking the distribution of the naturally occurring rat albumin. After the foreign albumin had been left within the ventricle for several hours, some of the cells of the cortical plate also contained the protein, again mimicking the normal distribution of albumin. These findings suggest that the presence of albumin within cells of the developing rat forebrain can largely be attributed to uptake rather than synthesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00318983
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Postnatal development of the telencephalon of the tammar wallaby (Macropus eugenii) (1985)
    Springer
    Anatomy and embryology 173 (1985), S. 81-94 
    Details
    ISSN: 1432-0568
    Keywords: Tammar wallaby ; Brain development ; Neocortex ; Histology ; Autoradiography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The sequence of development of cell layers in the neocortex of the tammar has been followed from 24 days gestation to 213 days postnatal. The tammar is born at 27 days gestation and the major period of its development occurs during the subsequent 250 days, most of this time being spent within the pouch. Although the pattern of differentiation of the cell layers appears to resemble that described for many Eutherian mammals, the neocortex is at an embryonic 2 layered stage at birth and a cortical plate is not present throughout the telencephalon until 10–15 days postnatal. A transient subplate zone, presenting a characteristic appearance with widely spaced rows of cells aligned parallel to the cortical surface, develops between 20 and 70 days postnatal, but no secondary proliferative region is seen in the subventricular zone of the dorso-lateral wall. Preliminary experiments with (3H)-thymidine injections indicate that the cortical plate follows the “inside-out” pattern of development described in many Eutherian mammals and that the oldest neurons are found in the parallel cell rows of the subplate zone. The importance of the late differentiation of the neocortex in relation to the time of birth and the resulting usefulness of the tammar as an experimental model of cortical development is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00707306
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Postnatal development of somatostatin-containing neurons in the visual cortex of normal and dark-reared rats (1993)
    Springer
    Experimental brain research 92 (1993), S. 473-478 
    Details
    ISSN: 1432-1106
    Keywords: Somatostatin ; Visual deprivation ; Cortical areas 17, 18, 18a ; Transience ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The distribution of somatostatin (SRIF)-immunoreactive neurons in the visual cortical areas 17, 18 and 18a of Wistar rats from birth to adulthood was followed in both normal and dark-reared animals. The SRIF neurons show difference in distribution amongst the three cortical areas studied as early as the first postnatal week. Area 17 was distinguished by fewer SRIF cells in the upper layers (I–III), which results in a lower overall density. The SRIF neurons in all areas appeared to increase in numbers up to about 3 weeks and then decline dramatically to adult levels, which were 14–19% of the peak levels. Although this decline was still obvious, it moderated to 25–31% in dark-reared animals. The greatest effect was seen in area 18 where, at 60 days of age, there were twice as many SRIF cells in darkreared as in normal controls. It is suggested that, under conditions of dark rearing, the overall pattern of development of SRIF neurons, being uninfluenced by extrinsic factors, reveals the cells' genetic potential.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00229035
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    The emergence of the cortical GABAergic neuron: with particular reference to some peptidergic subpopulations (1993)
    Springer
    Journal of neurocytology 22 (1993), S. 805-814 
    Details
    ISSN: 1573-7381
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The technical developments which have led to our present ability to make predictions about neurochemical identity from morphological observations are retraced with particular reference to the GABAergic neuron and its many subdivisions. The synaptology of four peptidergic sub-populations in the cerebral cortex is examined and described in detail. It is concluded that the recognition of Gray Type 1 and Type 2 synapse types continues to provide a key element in our analysis and understanding of the connectivity of the CNS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01181325
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    Paper (German National Licenses)
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