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  • 1
    Electronic Resource
    Electronic Resource
    Menadione-induced cytotoxicity to rat osteoblasts (1997)
    Springer
    Cellular and molecular life sciences 53 (1997), S. 967-976 
    Details
    ISSN: 1420-9071
    Keywords: Key words. Menadione; oxidative stress; osteoblasts; superoxide dismutase (SOD); catalase.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. Oxygen-derived free radical injury has been associated with several cytopathic conditions. Oxygen radicals produced by chondrocytes is an important mechanism by which chondrocytes induce matrix degradation. In the present study, we extend these observations by studying oxidative processes against osteoblasts. Osteoblasts were mixed in in vitro culture with 200 μM menadione. The cytotoxic effect of menadione-induced oxidative stress was monitored by lucigenin- or luminol-amplified chemiluminescence, tetrazolium assay and immunocytochemical study. Results showed that adding menadione induces an oxidative stress on osteoblasts, via superoxide and hydrogen peroxide production, that can be eradicated by superoxide dismutase (SOD) and catalase in a dose-dependent manner. Catalase and the appropriate concentration of dimethyl sulfoxide have a protective effect on cytotoxicity induced by menadione, whereas SOD does not. Menadione-treated osteoblasts have a strong affinity for annexin V, and the nuclei are strongly stained by TUNEL (TdT-mediated dUTP nick-end labelling). The results suggest that menadione-triggered production of reactive oxygen species leads to apoptosis of osteoblasts.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000180050118
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  • 2
    Electronic Resource
    Electronic Resource
    MRI manifestations of gastrointestinal lymphoma (1994)
    Springer
    Abdominal imaging 19 (1994), S. 495-500 
    Details
    ISSN: 1432-0509
    Keywords: MR studies, gastrointestinal tract ; Lymphoma, MR studies ; Intestines, MR studies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The magnetic resonance (MR) images of 11 cases of gastrointestinal lymphoma are presented. The findings include irregularly thickened mucosal folds, irregular submucosal infiltration, annular constricting lesion, exophytic tumor growth, mesenteric masses, and mesenteric/retroperitoneal lymphadenopathy. The tumors were homogeneous and intermediate in signal intensity on T1-weighted images. Heterogeneously increased signal intensities were noted on T2-weighted images. There was mild to moderate enhancement after intravenous administration of gadolinium dimeglumine (Gd-DTPA). The submucosal tumor infiltration might be outlined between the strongly GD-DTPA-enhanced mucosa and the low-intensity muscular layer. In one case that received tumor resection, the pathological examination showed destruction of most parts of the muscular layer, and the MR images did not disclose the low intensity muscular zone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00198248
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  • 3
    Electronic Resource
    Electronic Resource
    MRI demonstration of peritoneal implants (1994)
    Springer
    Abdominal imaging 19 (1994), S. 95-101 
    Details
    ISSN: 1432-0509
    Keywords: Peritoneal implants ; MR studies ; Air ; Intraperitoneal metastases
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The magnetic resonance imaging (MRI) findings of 12 proven cases of peritoneal implants, mainly carcinomatosis, were reviewed for evidence of peritoneal seedings. The seeded sites include the pouch of Douglas, the ileocecal and retrocecal regions, the right and left paracolic gutters, Morison's pouch, the right subdiaphragmatic parietal peritoneum, the greater and lesser omentum, the gastrocolic, gastrosplenic, and phrenicocolic ligaments, the small bowel mesentery, the sigmoid and transverse mesocolons, and the small and large bowel walls. Sizes varied from less than 1 cm to omental cake and bulky tumors. The findings include linear or tiny nodular infiltrations of the omentum and subperitoneal fat (ligamentous, mesenteric, and mesocolic), focal or segmental wall thickenings, loss of unilateral colonie haustration with sacculation on the contralateral side, and nodular soft tissue masses along different locations of the peritoneal surfaces. Air was introduced via an antegrade or retrograde method to act as a gastrointestinal contrast agent and was found to be useful for delineating the seedings. As is true with computed tomography scan, miliary implants are also not detectable with MRI. The sensitivity and specificity of MRI in detecting peritoneal implants remain to be determined.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00203480
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  • 4
    Electronic Resource
    Electronic Resource
    MRI Manifestations of gastrointestinal wall thickening (1994)
    Springer
    Abdominal imaging 19 (1994), S. 389-394 
    Details
    ISSN: 1432-0509
    Keywords: MR imaging, astrointestinal tract, intestine ; Wall thickening
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The appearance of gastrointestinal wall thickening of various entities is demonstrated on magnetic resonance imaging (MRI). The entities include benign gastric ulcer, gastric carcinoma, pancreatic carcinoma with direct invasion of stomach, duodenal leiomyoma, radiation enteritis, peritonitis, colonic carcinoma, recurrent carcinoma at the gastrojejunal anastomosis with direct extension to the transverse colon, colocolic intussusception, sigmoid diverticulitis with pericolonic abscess and fistula into the urinary bladder, and lymphoma of the stomach, duodenum, small bowel, and colon. Air was introduced antegradedly or retrogradedly into the alimentary tract to act as a contrast agent. When the bowel was distended by air, the normal bowel wall was barely visible or even invisible. Abnormal focal or segmental wall thickening was outlined between the intraluminal air and extraluminal fat. In some instances, the thickenings were better demonstrated on coronal or sagittal sections. The proper muscular layer of the bowel has a low-signal intensity and was delineated between the thickened mucosa—submucosa and extramural fat. Interruption of this low-intensity zone might represent tumor invasion through the muscular layer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00206921
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  • 5
    Electronic Resource
    Electronic Resource
    Abdominal pseudotumors and simulated lymphadenopathy in MRI: Differential features with the use of retrograde air insufflation (1994)
    Springer
    Abdominal imaging 19 (1994), S. 503-506 
    Details
    ISSN: 1432-0509
    Keywords: MR studies, gastrointestinal tract-MR studies, contrast medium ; Abdomen, MR studies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In order to evaluate the contribution of retrograde air insufflation in decreasing the occurrence of pseudotumor appearance and mimicked lymphadenopathy due to nonair-distended bowel loops, we retrospectively compared two groups of magnetic resonance (MR) examinations. In the group receiving retrograde air insufflation, 10.8% (67 of 619) of images showed a tumor-like lesion due to nonair-distended bowel loop(s), whereas in the group not receiving air introduction, a tumor-like lesion was simulated in 45.6% (140 of 307) of images. Furthermore, a collapsed bowel loop(s) mimicking an enlarged lymph node close to the aorta, inferior vena cava, or bilateral iliac vessels was found in 9.5% (24 of 252) of images of the latter group, in contrast to only 1.8% (9 of 505) of images of the former group. This study shows that retrograde air insufflation greatly reduces the occurrence of pseudotumor appearance and false impression of paraaortic, paracaval, or parailiac lymphadenopathy secondary to nonair-distended bowel loop(s).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00198250
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  • 6
    Electronic Resource
    Electronic Resource
    α-fetoprotein response predicts survival benefits of thalidomide in advanced hepatocellular carcinoma (2005)
    Oxford, UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 22 (2005), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background:  Radiographic measurements do not always reflect the biological response of hepatocellular carcinoma to drug therapy.Aims:  To evaluate the clinical implications of tumour marker (α-fetoprotein) response in advanced hepatocellular carcinoma patients with thalidomide treatment.Patients and methods:  Forty-two advanced hepatocellular carcinoma patients with baseline α-fetoprotein levels above 200 ng/mL and thalidomide therapy were included. Serum α-fetoprotein levels were measured every 4 weeks. α-fetoprotein response was defined as a 50% or greater reduction of α-fetoprotein levels for 4 or more weeks during treatment. Radiographic response was assessed by World Health Organization criteria; survivals were estimated by Kaplan–Meier method and prognostic factors were assessed by Cox's proportional hazard model.Results:  With intention-to-treat analysis, radiographic response and α-fetoprotein response were obtained in 7% (three of 42, 95% confidence interval: 0–15) and 24% (10 of 42, 95% CI: 10–38) of patients, respectively. All radiographic response was observed in α-fetoprotein responders. Multivariate analyses showed α-fetoprotein response was independent prognostic factor for both progression-free survival (relative risk = 0.394, 95% CI: 0.189–0.820, P = 0.013) and overall survival (relative risk = 0.241, 95% CI: 0.096–0.606, P =0.003), whereas radiographic response was not.Conclusion:  α-fetoprotein response can more accurately reflect the biological response of advanced hepatocellular carcinoma to thalidomide therapy than radiographic response.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.2005.02547.x
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  • 7
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    UNDER THE NATIONALIST GOVERNMENT (1927)
    Honolulu, etc. : Periodicals Archive Online (PAO)
    Pacific Affairs. (1927:Apr./May) 1 
    Details
    ISSN: 0030-851X
    Topics: Political Science , Sociology , Economics
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:5082-1927-000-00-000045
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  • 8
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    Unknown
    A MESSAGE TO CHINA'S YOUTH (1928)
    Honolulu, etc. : Periodicals Archive Online (PAO)
    Pacific Affairs. (1928:July) 4 
    Details
    ISSN: 0030-851X
    Topics: Political Science , Sociology , Economics
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:5082-1928-000-00-000081
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  • 9
    Electronic Resource
    Electronic Resource
    Nuclear Structure in Lymphoid Primordia (1966)
    [s.l.] : Nature Publishing Group
    Nature 209 (1966), S. 381-383 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THE first lymphoid cells appear in the thymus of vertebrates and in the thymus and the bursa of Fabricius of avian vertebrates and emigrate to lymphoid tissues which differentiate later1. The recognition and interpretation of this phenomenon differ sharply from earlier views. Most importantly, it ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/209381a0
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