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  • 1
    Electronic Resource
    Electronic Resource
    Menadione-induced cytotoxicity to rat osteoblasts (1997)
    Springer
    Cellular and molecular life sciences 53 (1997), S. 967-976 
    Details
    ISSN: 1420-9071
    Keywords: Key words. Menadione; oxidative stress; osteoblasts; superoxide dismutase (SOD); catalase.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. Oxygen-derived free radical injury has been associated with several cytopathic conditions. Oxygen radicals produced by chondrocytes is an important mechanism by which chondrocytes induce matrix degradation. In the present study, we extend these observations by studying oxidative processes against osteoblasts. Osteoblasts were mixed in in vitro culture with 200 μM menadione. The cytotoxic effect of menadione-induced oxidative stress was monitored by lucigenin- or luminol-amplified chemiluminescence, tetrazolium assay and immunocytochemical study. Results showed that adding menadione induces an oxidative stress on osteoblasts, via superoxide and hydrogen peroxide production, that can be eradicated by superoxide dismutase (SOD) and catalase in a dose-dependent manner. Catalase and the appropriate concentration of dimethyl sulfoxide have a protective effect on cytotoxicity induced by menadione, whereas SOD does not. Menadione-treated osteoblasts have a strong affinity for annexin V, and the nuclei are strongly stained by TUNEL (TdT-mediated dUTP nick-end labelling). The results suggest that menadione-triggered production of reactive oxygen species leads to apoptosis of osteoblasts.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000180050118
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  • 2
    Electronic Resource
    Electronic Resource
    A computational and experimental study of the bending induced at a double-triple helix junction
    Amsterdam : Elsevier
    Biophysical Chemistry 45 (1992), S. 143-152 
    Details
    ISSN: 0301-4622
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0301-4622(92)87006-5
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  • 3
    Electronic Resource
    Electronic Resource
    Magnetic resonance imaging of glomus tumour in the hand (1997)
    Springer
    International orthopaedics 20 (1997), S. 342-345 
    Details
    ISSN: 1432-5195
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé. La tumeur glomique de la main est une tumeur bénigne développée à partir de l’appareil neuro-myo-artériel. La localisation la plus fréquente de la tumeur glomique est la phalange distale. La symptomatologie est une triade classique: douleur, tuméfaction molle et sensibilitéà la température. 10 cas ont été examinés avec un examen en résonance magnétique nucléaire pré-opératoire. Les patients étaient de sexe féminin avec un âge moyen de 43 ans et ils présentaient tous sauf 2 la symptomatologie classique. La durée moyenne d’évolution avant le traitement était de 7.4 ans. La résonance magnétique nucléaire a toujours apporté une description précise de la tumeur et a permis le diagnostic chez les 4 patients qui ne présentaient pas la coloration bleue sous inguéale. La lésion montrait un bas signal en séquence T1 et un haut signal en séquence T2. Toutes les tumeurs, sauf 3, étaient localisées dans la région sous-inguéale. Tous les patients ont été traités par une excision chirurgicale avec confirmation anatomopathologique. Les suites chirurgicales ont toujours été simples, sans séquelle. L’examen en résonance magnétique nucléaire a montré une bonne différenciation entre le tissu tumoral et les tissus normaux et s’est avéré une méthode non invasive et pratique pour caractériser ces tumeurs glomiques de la main.
    Notes: Summary. Glomus tumours of the hand are benign tumours that arise from the neuromyoarterial apparatus. The most common site for a glomus tumour is in the distal phalanx. They frequently display a classic triad of symptoms – pain, tenderness and temperature sensitivity. Ten treated cases examined with magnetic resonance imaging (MRI) preoperatively are described. All were female with a mean age of 43 years. All except 2 suffered the classic triad of symptoms. The mean duration from onset of symptoms to therapeutic intervention was 7.4 years. MRI depicted the tumours in excellent detail and aided diagnosis in the 4 patients without subungual blue discolouration. The lesions showed a low signal on the T1-weighted image and a high signal on the T2-weighted image. All except 3 were located in the subungual region. All patients underwent surgical excision with pathological confirmation. The post-operative course was smooth and there were no sequelae. High resolution MRI, providing a clear contrast between tumorous and normal tissues, has proved to be a useful non-invasive method for imaging glomus tumours in the hand.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002640050093
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  • 4
    Electronic Resource
    Electronic Resource
    Nitrogenase activity of two genotypes of Acacia mangium as affected by phosphorus nutrition (1992)
    Springer
    Plant and soil 144 (1992), S. 51-58 
    Details
    ISSN: 1573-5036
    Keywords: Acacia mangium ; nitrogenase activity ; phosphorus nutrition ; plant genotypes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract The specific nodulation, nitrogenase activity (acetylene reduction) and budgets of carbon allocation to respiration by nodulated roots were examined in two provenances of Acacia mangium Willd. grown in a glasshouse for 17 weeks to investigate the effects of soil phosphorus and genotypes of the host plant on symbiotic nitrogen fixation. Application of phosphorus (0–80 mg P kg-1 soil) increased specific nodulation (g nodule dry weight g-1 plant dry weight) of provenance Ma11 by two-fold and the percentage of nodulated root respiration allocated to nitrogenase by 50%, but had no effect on specific activity of nitrogenase or specific respiration coupled with nitrogenase activity. Improved phosphorus nutrition increased the specific nitrogenase activity of provenance Ma9 by 2-fold, the percentage of nodulated root respiration allocated to nitrogenase, and specific nitrogenase-linked respiration by 50%, respectively, but had no effect on the specific nodulation. The percentage of respiration coupled with nitrogenase activity in nodulated root respiration by provenance Ma9 was 60–70% higher than that in provenance Ma11, regardless of phosphorus levels applied. At the optimal level of phosphorus addition (10 mg P kg-1 soil), provenance Ma9 had a lower dry mass than provenance Ma11. This was accompanied by a lower nodulated root respiration and a higher percentage of nodulated root respiration allocated to nitrogenase activity in provenance Ma9.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00018844
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    Paper (German National Licenses)
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