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  • 1
    Electronic Resource
    Electronic Resource
    Intrahepatic cholangiocarcinoma in Taiwan (1999)
    Springer
    Journal of hepato-biliary-pancreatic surgery 6 (1999), S. 136-141 
    Details
    ISSN: 1436-0691
    Keywords: Key words: cholangiocellular carcinoma ; hepatolithiasis ; hepatic resection ; common bi1e duct exploration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: We report our experience of the surgical treatment of intrahepatic cholangiocarcinoma (ICC) in Taiwanese patients. A tota1 of 162 patients with histologically proven ICC were treated of whom 106 (65.4%) had associated hepatolithiasis. Patients with hepatolithiasis were in earlier stages than those without hepatolithiasis. Two-thirds of the patients with hepatolithiasis presented with acute cholangitis, and two-thirds of those without hepatolithiasis presented with hepatomegaly. The rate of hepatic resection was 29.6% (48 of 162), and these rates were 31.1% and 26.8% for the patients with and without hepatolithiasis, respectively. Ninety-three percent of the patients with hepatolithiasis underwent common bile duct exploration, compared with 18% of those without hepatolithiasis. The surgical mortality rates were 3.7% (6/162), for all patients, and 3.8% and 3.6% for patients with and without hepatolithiasis, respectively. The morbidity rate was much higher in the patients with hepatolithiasis (37.7% vs 16.1%). The 1-, 3-, and 5-year survival rates were 35.5%, 20.5%, and 16.5% in the patients with hepatolithiasis and 27.2%, 8.8%, and 7.8% in those without hepatolithiasis. Concomitant hepatolithiasis prevented precise diagnosis preoperatively and precipitated biliary sepsis, which affected resectability and increased postoperative morbidity. Hepatolithiasis per se did not influence long-term survival.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005340050096
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  • 2
    Electronic Resource
    Electronic Resource
    Delayed presentation of bile duct injuries after laparoscopic cholecystectomy (1994)
    Springer
    Journal of hepato-biliary-pancreatic surgery 1 (1994), S. 210-215 
    Details
    ISSN: 1436-0691
    Keywords: laparoscopic cholecystectomy ; bile duct injury ; cholelithiasis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Bile duct injury is a serious complication of laparoscopic cholecystectomy, with 50% of bile duct injuries showing a delayed presentation. We experienced four patients (one male and three female) with bile duct injuries after laparoscopic cholecystectomy performed and referred by a local practitioner. The patients' ages ranged from 34 to 63 years. Symptoms included abdominal pain, anorexia, jaundice, ascites, ileus, fever, and tarry stool. Ductal injuries were a result of electrocautery burn in two patients and biliary strictures were due to malapplication of endoclips in the remaining two. The observed bile duct injuries, confirmed by ultrasonography, computed tomography (CT) scanning, and cholangiographic studies, were successfully treated by choledochotomy with a silastic T-tube stent. To avoid bile duct injuries, laparoscopic cholecystectomy should be performed by a well trained and experienced hepatobiliary surgeon, who should ensure accurate identification of the anatomical structures of Calot's triangle, careful dissection and management of intraoperative bleeding, and a lower threshold for conversion to open surgery.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01222252
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  • 3
    Electronic Resource
    Electronic Resource
    Color Doppler ultrasound in benign and malignant breast tumors (1999)
    Springer
    Breast cancer research and treatment 57 (1999), S. 193-199 
    Details
    ISSN: 1573-7217
    Keywords: color Doppler ; diognosis ; ultrasound ; benign lesions ; pulsatility index ; resistance index ; systolic peak flow velocity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To study the flow indices of color Doppler ultrasound in the differentiation of malignant and benign breast tumors, data of 1124 female patients with breast lesions were analyzed. Of 1124 breast lesions, 590 (525%) were benign and 534 (47.5%) were malignant. Color Doppler scanning detected vascularity in 505 (85.6%) of benign lesions and 509 (95.3%) of malignant tumors. The tumors without detectable vascularization (1.9±0.1 cm) were significantly (p〈0.0001) smaller than the tumors with vascularization (2.7±0.1 cm). The age of the patients with malignant tumors was older than that of the patients with benign lesions. The size of malignant tumors was significantly larger than that of benign lesions. Significantly higher values of vessel number, resistance index (RI), pulsatility index (PI), and systolic peak flow velocity (Vmax) were found in carcinomas but the striking overlap of the values did not allow defining cutoff values which allow an accurate differentiation. Vmax did not correlate with the size of tumors. When tumors were grouped as T1 (2 cm or less), T2 (〉2 cm, but not 〉5 cm), and T3 (〉5 cm), the results were similar to those of all breast tumors. In conclusion, number of vessels, RI, PI, and Vmax do not provide accurate differentiation of benign and malignant tumors. However, average values of these flow indices of malignant tumors were significantly larger than those of benign lesions. Tumors with larger values of vessel number, RI, PI or Vmax require further studies to disclose the possibility of malignant tumors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006277617884
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  • 4
    Electronic Resource
    Electronic Resource
    Aberrant expression of TSG101 in Taiwan Chinese breast cancer (2000)
    Springer
    Breast cancer research and treatment 60 (2000), S. 259-266 
    Details
    ISSN: 1573-7217
    Keywords: TSG101 ; breast cancer ; tumor suppressor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Functional inactivation of the tsg101 gene in mouse fibroblasts results in cell transformation and the ability to form metastatic tumors in nude mice. The human tsg101 gene was mapped to chromosome 11q15.1-2 and found to mutate in some cancer patients. To test the expression pattern of the tsg101 gene in Chinese breast cancer patients, we analyzed the mRNA by RT-PCR in 51 breast cancer patients. The full-length tsg101 and 7 truncated transcripts were detected in both normal and matched tumor tissues. A short transcript with a deletion of nucleotides 154–1054 is frequently presented in late-stage breast cancers. TSG101 protein expression was also detected by Western blot analysis in 30 breast cancer patients. A predicted full-length 46 kDa and three proteins with smaller molecular weight were detected. The full-length 46 kDa protein was less expressed in tumor specimens. Immunohistochemical stains from 10 patients of each stage 0–4 revealed that TSG101 protein was predominantly present in the cytoplasm. Cell nuclei were occasionally immunopositive and the chromosomes were deeply stained during cell division. The intracellular location and the expression of TSG101 protein were both not stage-dependent in primary breast cancers. In addition, normal mammary glands were more homogenously immunopositive than invasive ductal carcinoma. These results support the notion that the aberrant expression of TSG101 in breast cancer is associated with altered cell growth.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006426400524
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    Paper (German National Licenses)
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