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  • 1
    Electronic Resource
    Electronic Resource
    Dermatofibroma is a clonal proliferative disease (2000)
    Copenhagen : Munksgaard International Publishers
    Journal of cutaneous pathology 27 (2000), S. 0 
    Details
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Benign fibrous histiocytoma of the skin or dermatofibroma (DF) has been regarded as a fibrohistiocytic tumor. Whether DF is a neoplastic growth or a reactive process has not been settled. Since a neoplastic process is clonal in nature, clonal analysis of DF was conducted to see if DF is a clonal disease. Fresh specimens of 13 DFs and 2 hypertrophic scars obtained from female patients were studied. The adjacent nonlesional skin tissues served as controls. The clonal analysis was based on the methylation pattern of the polymorphic X-chromosome linked androgen-receptor gene (HUMARA). Eight DFs and 1 hypertrophic scar were heterozygous at the androgen receptor gene and could be analyzed. All 8 informative DFs showed a significant reduction in one of the allelic bands compared with the corresponding bands of the nonlesional tissue after Hha I digestion. Therefore, DF is a clonal proliferative disease. In contrast, 1 hypertrophic scar showed a polyclonal pattern of X-chromosome inactivation. We conclude that DF is a clonal disease favoring a neoplastic process.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-0560.2000.027001036.x
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  • 2
    Electronic Resource
    Electronic Resource
    Case Report: Refractory Pancreatitis Secondary to Ruptured Hepatocellular Carcinoma into the Common Bile Duct (1998)
    Springer
    Digestive diseases and sciences 43 (1998), S. 21-25 
    Details
    ISSN: 1573-2568
    Keywords: PANCREATITIS ; HEPATOCELLULAR CARCINOMA ; JAUNDICE ; CHOLANGIOGRAPHY
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018855516613
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Aberrant expression of TSG101 in Taiwan Chinese breast cancer (2000)
    Springer
    Breast cancer research and treatment 60 (2000), S. 259-266 
    Details
    ISSN: 1573-7217
    Keywords: TSG101 ; breast cancer ; tumor suppressor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Functional inactivation of the tsg101 gene in mouse fibroblasts results in cell transformation and the ability to form metastatic tumors in nude mice. The human tsg101 gene was mapped to chromosome 11q15.1-2 and found to mutate in some cancer patients. To test the expression pattern of the tsg101 gene in Chinese breast cancer patients, we analyzed the mRNA by RT-PCR in 51 breast cancer patients. The full-length tsg101 and 7 truncated transcripts were detected in both normal and matched tumor tissues. A short transcript with a deletion of nucleotides 154–1054 is frequently presented in late-stage breast cancers. TSG101 protein expression was also detected by Western blot analysis in 30 breast cancer patients. A predicted full-length 46 kDa and three proteins with smaller molecular weight were detected. The full-length 46 kDa protein was less expressed in tumor specimens. Immunohistochemical stains from 10 patients of each stage 0–4 revealed that TSG101 protein was predominantly present in the cytoplasm. Cell nuclei were occasionally immunopositive and the chromosomes were deeply stained during cell division. The intracellular location and the expression of TSG101 protein were both not stage-dependent in primary breast cancers. In addition, normal mammary glands were more homogenously immunopositive than invasive ductal carcinoma. These results support the notion that the aberrant expression of TSG101 in breast cancer is associated with altered cell growth.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006426400524
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  • 4
    Electronic Resource
    Electronic Resource
    Hepatocellular Carcinoma Complicated with Coexisting Hepatolithiasis (Pitfalls in Diagnosis and Management) (1998)
    Springer
    Digestive diseases and sciences 43 (1998), S. 2483-2488 
    Details
    ISSN: 1573-2568
    Keywords: HEPATOCELLULAR CARCINOMA ; HEPATOLITHIASIS ; CHOLANGIOCARCINOMA ; α-FETOPROTEIN ; CARCINOEMBRYONIC ANTIGEN
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Nineteen patients with hepatocellular carcinomaassociated with hepatolithiasis were retrospectivelyanalyzed. Eleven of the 19 patients presented withhepatolithiasis-related biliary infection. Diagnosis was erroneously assumed to be hepatolithiasisalone, liver abscess, or cholangiocarcinoma in five of11 patients before surgery was attempted. Middle-age,male sex, liver cirrhosis, hepatitis B or C infection, abnormal α-fetoprotein, and negativecarcinoembryonic antigen raised the suspicion ofassociated hepatocellular carcinoma rather thancholangiocarcinoma in patients with hepatolithiasis.Antibiotics and nonoperative methods to resolve biliaryinfection first, followed by hepatectomy, in selectedcases, to eradicate hepatocellular carcinoma andhepatolithiasis simultaneously provides the best chance for long-term survival. Otherwise, patientsoften died of hepatolithiasis-related biliary sepsisrather than hepatocellular carcinoma per se in the longrun.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1026694501805
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    Paper (German National Licenses)
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