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  • 1
    Electronic Resource
    Electronic Resource
    A new highly polymorphic marker in the 5' untranslated region of HLA-F shows strong allelic association with haemochromatosis (1996)
    Springer
    Human genetics 〈Berlin〉 97 (1996), S. 228-231 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The 5′ untranslated region of HLA-F contains a polypurine tract comprising repeats of tri- and hexa-nucleotide motifs. We have recently demonstrated that this polypurine tract is highly polymorphic by using the polymerase chain reaction. Here, we demonstrate that some of the alleles can be explained by a deletion of approximately 100 by DNA and show that alleles of this novel, highly polymorphic locus are as strongly associated with haemochromatosis as HLA-A3 or D6S105-8. The observed frequency of heterozygosity at HLA-RF is extremely high (95%) and this locus has been found to be informative in pedigrees that are non-informative at HLA-A and D6S105. We also show an example of replication slippage at HL,A-F in one pedigree.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02265271
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  • 2
    Electronic Resource
    Electronic Resource
    A new highly polymorphic marker in the 5′ untranslated region of HLA-F shows strong allelic association with haemochromatosis (1996)
    Springer
    Human genetics 〈Berlin〉 97 (1996), S. 228-231 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The 5′ untranslated region of HLA-F contains a polypurine tract comprising repeats of tri- and hexa-nucleotide motifs. We have recently demonstrated that this polypurine tract is highly polymorphic by using the polymerase chain reaction. Here, we demonstrate that some of the alleles can be explained by a deletion of approximately 100 bp DNA and show that alleles of this novel, highly polymorphic locus are as strongly associated with haemochromatosis as HLA-A3 or D6S105-8. The observed frequency of heterozygosity at HLA-RF is extremely high (95%) and this locus has been found to be informative in pedigrees that are non-informative at HLA-A and D6S105. We also show an example of replication slippage at HLA-F in one pedigree.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02265271
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Generalized Tamm–Dancoff approximation (GTDA) and random-phase approximation (GRPA) calculations on LiH, Be, and Li2 (1987)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 86 (1987), S. 4523-4530 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The theory for polarization propagator calculations based on a correlated reference state in the form of a spin singlet restricted antisymmetrized geminal power (AGP) is discussed. Particular attention is paid to the calculation of excitation energies and transition moments for the molecules over all internuclear separations, i.e., not just single point vertical energies, which is done in standard RPA or in higher-order treatments using perturbation methods. Simple applications to the Be atom, and the LiH and Li2 molecules are used to illustrate how this simple correlated state, which is completely determined by the choice of orbital basis (i.e., no choice of configurations is necessary), can cure the notorious consistency problems and the instabilities against the breaking of symmetry, which plague standard RPA based on a Hartree–Fock (HF) single determinantal reference state.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.452728
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  • 4
    Electronic Resource
    Electronic Resource
    Investigations into the Mechanism of Action of a Novel Nitric Oxide Generator on Cellular Respiration (1996)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 67 (1996), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Nitric oxide may regulate cellular respiration by competition with oxygen at mitochondrial cytochrome oxidase. Using an astrocyte-derived cell line, we have compared the mechanism of action of the nitric oxide-generating compound Roussin's black salt with that of sodium nitroprusside on cellular oxygen consumption. Intense light exposure induced the release of large quantities of nitric oxide from both of the donor compounds. However, in room light only Roussin's black salt generated low levels of the radical. Simultaneous measurement of oxygen consumption and of nitric oxide production demonstrated that sodium nitroprusside only had inhibitory actions when exposed to intense light (nitric oxide release), whereas Roussin's black salt had inhibitory actions in room light. Extracellular haemoglobin did not prevent the inhibition of respiration rate induced by Roussin's black salt even though stimulation of nitric oxide release on light exposure was markedly reduced. Preincubation of cells with Roussin's black salt and subsequent measurement of levels of light-liberated nitric oxide demonstrated that the compound was rapidly internalised. The uptake of sodium nitroprusside was minimal. These data suggest that, in contrast to sodium nitroprusside, the cellular internalisation of Roussin's black salt allows site-directed nitric oxide release and very effective inhibition of cellular respiration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.1996.67031200.x
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  • 5
    Electronic Resource
    Electronic Resource
    Mechanism of combustion synthesis of silicon carbide (1994)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 75 (1994), S. 7252-7257 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The mechanism of self-propagating high-temperature synthesis (SHS) or combustion synthesis of SiC has been investigated using pellets consisting of silicon and carbon powders. The combustion reaction was initiated by rapidly heating the pellet on a graphite strip. The reaction products were analyzed using scanning and transmission electron microscopy, x-ray diffraction, and Raman spectroscopy. The results show that it is possible to produce β-SiC without any residual silicon and carbon. Occasionally, a very small number density of α-SiC precipitates embedded in the β-SiC matrix was observed. Based upon the microstructural features, it is proposed that the formation of SiC involves the dissolution of carbon into liquid silicon, diffusion of C into liquid silicon, and subsequent precipitation of SiC. The size of the SiC crystallites is determined by the diffusion coefficient of carbon in liquid silicon and the time available for SiC precipitation. The activation enthalpy for the SHS process is estimated to be 59±3 kcal/mol.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.356660
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  • 6
    Electronic Resource
    Electronic Resource
    Pulsed laser deposition and characterization of epitaxial Cu/TiN/Si(100) heterostructures (1994)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 65 (1994), S. 2565-2567 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Three-dimensional epitaxial Cu/TiN/Si(100) heterostructures have been grown by pulsed laser deposition using a single chamber, in situ processing method. The epitaxial TiN layers on Si(100) were grown at 600 °C and epitaxial Cu layers on TiN/Si(100) in the temperature range 200–600 °C using optimized laser parameters. These structures were characterized using three-axis x-ray diffraction (aitch-theta, Φ, Ψ scans) technique and high-resolution transmission electron microscopy. The results clearly indicate cube-on-cube epitaxial alignment along the three axes, i.e., 〈100〉Cu(parallel)〈100〉TiN(parallel)〈100〉Si. The Cu/TiN and TiN/Si interfaces were found to be quite sharp without any indication of interfacial reaction. The growth mechanism of copper on TiN was found to be three dimensional, with the size of island varying from 0.3 to 1.5 μm. We discuss domain matching epitaxy as a mechanism of growth in these large lattice mismatch systems, where three lattice constants of Si(5.43 A(ring)) match with four of TiN(4.24 A(ring)) and seven units of Cu(3.62 A(ring)) match with six of the TiN. The implications of these results in the fabrication of advanced microelectronic devices are discussed. © 1994 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.112994
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  • 7
    Electronic Resource
    Electronic Resource
    Epitaxial growth of TiN films on (100) silicon substrates by laser physical vapor deposition (1992)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 61 (1992), S. 1290-1292 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We report epitaxial growth of TiN films having low resistivity on (100) silicon substrates using pulsed laser deposition method. The TiN films were characterized using x-ray diffraction, Rutherford backscattering, four-point-probe ac resistivity, high resolution transmission electron microscopy and scanning electron microscopy techniques and epitaxial relationship was found to be 〈100〉 TiN (parallel) 〈100〉 Si. TiN films showed 10%–20% channeling yield. In the plane, four unit cells of TiN match with three unit cells of silicon with less than 4.0% misfit. This domain matching epitaxy provides a new mechanism of epitaxial growth in systems with large lattice misfits. Four-point-probe measurements show characteristic metallic behavior of these films as a function of temperature with a typical resistivity of about 15 μΩ cm at room temperature. Implications of low-resistivity epitaxial TiN in silicon device fabrication are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.107568
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  • 8
    Electronic Resource
    Electronic Resource
    Pulsed laser deposition of epitaxial Si/TiN/Si(100) heterostructures (1994)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 64 (1994), S. 1236-1238 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We have successfully deposited multilayer Si/TiN/Si(100) epitaxial heterostructures using pulsed laser deposition technique. This silicon-on-conductor device configuration has potential applications in three-dimensional integrated circuits and radiation hardened devices. The Si and TiN films were deposited by pulsed laser (KrF: λ=248 nm, τ =25 ns) physical vapor deposition technique at a substrate temperature of 600 °C in a chamber maintained at a vacuum of ∼10−7 Torr. The epitaxial nature of the films was characterized using x-ray diffraction, Rutherford backscattering, and high resolution transmission electron microscopy techniques. The two interfaces (100)TiN/Si(100)substrate and (100)Si/(100)TiN layers were quite sharp without any indication of interfacial reaction between them. The epitaxial relationship was found to be 〈100〉Si(parallel)〈100〉TiN(parallel)〈100〉Si. In the plane, four unit cells of TiN matched with three unit cells of silicon with less than 4.0% misfit. This domain matching epitaxy provides a mechanism of epitaxial growth in systems with large lattice mismatch. Modeling of the domain matching epitaxial growth in the high lattice mismatch (100)Si/(100)TiN/(100)Si system and possible device implications are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.110850
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  • 9
    Electronic Resource
    Electronic Resource
    Pancreatic function testing (2003)
    Oxford, UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 17 (2003), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Pancreatic function tests are most commonly used to diagnose chronic pancreatitis. These tests include tests which document exocrine or endocrine gland insufficiency and tests which instead measure gradations of decreased secretory capacity. The tests in the former category generally become abnormal when advanced, longstanding chronic pancreatitis is present. Tests in the latter category, however, have the potential to detect chronic pancreatitis at an earlier stage than other available diagnostic tests, including commonly used imaging tests such as computed tomography and endoscopic retrograde cholangiopancreatography. This potential advantage of diagnostic sensitivity is, however, counterweighed by the fact that these tests which measure stimulated secretory capacity are only available at a very few referral centres. This article will review the variety of pancreatic function tests and describe their rationale, accuracy, cost, and clinical usefulness.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.2003.01495.x
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  • 10
    Electronic Resource
    Electronic Resource
    The production of pregnancy associated alpha glycoprotein (PAG) from human peripheral blood mononuclear cells (1987)
    Springer
    Clinical rheumatology 6 (1987), S. 417-422 
    Details
    ISSN: 1434-9949
    Keywords: Pregnacy Associated Alpha2-Glycoprotein ; Oestrogens ; Indomethacin ; Rheumatoid Arthritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A sensitive enzyme-linked immuno-assay has been developed which can measure the amounts of pregnancy-associated alpha2 glycoprotein (PAG) producted by human peripheral blood mononuclear cells (MNC) in culture. Ethinyl oestradiol, indomethacin and pokewee nitrogen (PWM) stimulated PAG production directly while indomethacin produced an additional increase in PAG production by PWM-stimulated MNC probably by inhibiting the production of prostaglandins with down-regulatory effects on the MNC. Oestrogen stimulation of MNC produced significant increases in PAG levels only by the MNC of women on oral contraceptives but not from the cells of males or of females of reproductive age not on oral contraceptives. Since PAG has immunosuppressive properties these observations may be of relevence in understanding the mechanisms involved in the significant decrease in the incidence of rheumatoid arthritis in women takin oral contraceptives.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02206843
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