ISSN:
1432-0428
Keywords:
Streptozotocin-diabetes
;
autoradiography
;
radioactive
;
pancreas
;
liver
;
kidney
;
blood
;
metabolism
;
distribution
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The distribution and cellular accumulation, in the rat, of three specifically 14C-labelled forms of streptozotocin were investigated. A significant pancreatic accumulation of radioactivity was observed with (3′-methyl-14C)-streptozotocin only. Autoradiographic studies revealed high levels of bound radioactivity in the islet tissue following the administration of (3′-methyl-14C)-streptozotocin whereas much lower levels of radioactivity were detected in the pancreatic tissue following the administration of either (1-14C)-streptozotocin or (2′-14C)-streptozotocin. In the pancreas, the amount of radioactivity bound to islet tissue was always significantly higher than that bound to acinar tissue. In addition to the islet tissue, the kidney cortex showed a very high level of bound radioactivity after the administration of (3′-methyl-14C)-streptozotocin. The results suggest that streptozotocin is rapidly metabolised by the rat. The apparent specificity for the accumulation of radiolabel from (3′-methyl-14C)-streptozotocin suggests that a metabolite derived from the methyl bearing ureido side chain of the drug may be specifically involved in the induction of tissue damage and the consequent development of diabetes.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00428976
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