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  • 1
    Electronic Resource
    Electronic Resource
    Cambridge : Cambridge University Press
    Greece and Rome 16 (1947), S. 8-16 
    ISSN: 0017-3835
    Source: Cambridge Journals Digital Archives
    Topics: Archaeology , Classical Studies
    Notes: At first sight it might appear that the scope of Virgil's influence had been predetermined from the beginning, as far surpassing that of any classical author. His poems became a school-book within a few years of his death: he is one of the very few Latin writers whose work remained known, without any real break, from the day that it was written until now: his genius was recognized in his own lifetime and onwards with very little question, and wherever Latin has been read at all he has been one of the authors read. More than that, his text has been pored over, annotated, translated, and sedulously imitated, from his own time to ours, sometimes chiefly for antiquarian reasons, but usually with an appreciation of its beauty and a devotion amounting to a cult. This Society has been founded in the belief that Such an influence should be in one way or another permanent, and this conviction in itself raises the consideration of scope: the question, I mean, whether Virgil may be regarded as a European influence, part of the inheritance of European culture at its widest range, or whether there is anything in his poetry which makes him more even than the greatest European classic—one of the very few writers of universal importance. The question is bound up with the whole problem of classical education and how far it should be fundamental in the world-order of the future, which will not be wholly, perhaps not primarily, European.Another question is relevant to this, though at first sight rather distantly so.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Cambridge : Cambridge University Press
    Greece and Rome 11 (1942), S. 49-58 
    ISSN: 0017-3835
    Source: Cambridge Journals Digital Archives
    Topics: Archaeology , Classical Studies
    Notes: The best Latin poetry loses nearly all its quality in translation and even the beginnings of its appreciation need a little knowledge of Latin. This is not entirely a truism, or universally applicable. Some poetry, like Homer and the Psalter, can be truly though partially apprehended through translations; but the spirit of Latin poetry, deprived of its own embodiment, eludes us. The Italian Camena, however wooingly the great translators approach her, ‘flies, plunges deeper in the bowering wood’, in that sylvan felicity of sound answering to sound, which links Latin poetry to the senses rather than to the intellect, and refuses to yield up its secret in any language except its own.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Cambridge : Cambridge University Press
    Greece and Rome 19 (1950), S. 129-136 
    ISSN: 0017-3835
    Source: Cambridge Journals Digital Archives
    Topics: Archaeology , Classical Studies
    Notes: Socrates. Good-morning, Eleutheros. Obviously something delightful has happened to you, to make you leave your work so early in the day—and to hurry along too, with your head in the clouds and a smile on your face, not even recognizing your friends! And Polytechnos has thrown down his chisel, too! Whatever is the good news?
    Type of Medium: Electronic Resource
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  • 4
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    Unknown
    London : Periodicals Archive Online (PAO)
    Journal of theological studies. 17:3 (1916:Apr.) 299 
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  • 5
    ISSN: 1434-9949
    Keywords: Kidney ; NSAID ; Tenoxicam ; Osteoarthritis ; Rheumatoid Arthritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Fifty-eight patients, aged 48–87 years, with impaired renal function and mean initial creatinine clearance of 52.1 mls/min were recruited to a 12-week open study of tenoxicam 20 mg/day for osteoarthrosis or rheumatoid arthritis. Renal function was mea sured before and after a brief run-in period when patients discontinued all nonsteroidal anti-inflammatory drugs, taking paracetamol alone, prior to monthly monitoring thereafter. Fifty-four% of patients completed the study, the others being withdrawn from lack of efficacy (17%), adverse events (24%) or both (5%). During the run-in period the mean creatinine clearance of 28 patients completing the trial improved to 64.7 mls/min and then dropped to 57.9 mls/min during the course of 12 weeks treatment with tenoxicam. Serial analysis of haematological and biochemical safety parameters showed no drug-induced change of significance. Twenty-three% of patients felt worse and 45% better at the end of treatment. Seventeen patients withdrew because of adverse events. These were normally gastrointestinal and always unrelated to further deterioration in renal function. Tenoxicam, 20 mg/day, can be given safely for a period of at least three months in patients with mild or moderate renal impairment.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1573-5028
    Keywords: gene expression ; photosynthesis ; protein turnover ; psbA ; tac promoter ; D1 protein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Over-expression of the psbAIII gene encoding for the D1 protein (form II; D1:2) of the photosystem II reaction centre in the Synechococcus sp. PCC 7942 was studied using a tac promoter and the lacI Q system. Over-expression was induced with 40 μg/ml IPTG in the growth medium for either 6 or 12 h at growth irradiance (50 μmol photons m-2 s-1). This treatment doubled the amount of psbAII/III mRNA and the D1:2 protein in membranes but decreased the amount of psbAI messages and the D1:1 protein. The total amount of both heterodimeric reaction centre proteins, D1 and D2, remained constant under growth light conditions, indicating that the number of PSII centres in the membranes was not affected, only the form of the D1 protein was changed from D1:1 to D1:2 in most centres. When the cells were photoinhibited either at 500 or 1000 μmol photons m-2 s-1, in the presence or absence of the protein synthesis inhibitor lincomycin, the D1:2 protein remained at a higher level in cells in which over-expression had been induced by IPTG. These cells were also less prone to photoinhibition of PSII. It is suggested that the tolerance of cells to photoinhibition increases when most PSII reaction centres contain the D1:2 protein at the beginning of high irradiance. This tolerance is further strengthened by maintaining psbAIII gene over-expression during the photoinhibitory treatment.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1573-5028
    Keywords: gene expression ; photosynthesis ; protein turnover ; psbA ; tac promoter
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The unicellular cyanobacterium Synechococcus sp. PCC 7942 has three psbA genes encoding two different forms of the photosystem II reaction centre protein D1 (D1:1 and D1:2). The level of expression of these psbA genes and the synthesis of D1:1 and D1:2 are strongly regulated under varying light conditions. In order to better understand the regulatory mechanisms underlying these processes, we have constructed a strain of Synechococcus sp. PCC 7942 capable of over-producing psbA mRNA and D1 protein. In this study, we describe the over-expression of D1:1 using a tac-hybrid promoter in front of the psbAI gene in combination with lacI Q repressor system. Over-production of D1:1 was induced by growing cells for 12 h at 50 μmol photons m-2 s-1 in the presence of 40 or 80 μg/ml IPTG. The amount of psbAI mRNA and that of D1:1 protein in cells grown with IPTG was three times and two times higher, respectively. A higher concentration of IPTG (i.e., 150 μg/ml) did not further increase the production of the psbAI message or D1:1. The over-production of D1:1 caused a decrease in the level of D1:2 synthesised, resulting in most PSII reaction centres containing D1:1. However, the over-production of D1:1 had no effect on the pigment composition (chlorophyll a or phycocyanin/number of cells) or the light-saturated rate of photosynthesis. This and the fact that the total amounts of D1 and D2 proteins were not affected by IPTG suggest that the number of PSII centres within the membranes remained unchanged. From these results, we conclude that expression of psbAI can be regulated by using the tac promoter and lacI Q system. However, the accumulation of D1:1 protein into the membrane is regulated by the number of PSII centres.
    Type of Medium: Electronic Resource
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