ISSN:
1573-6849
Keywords:
β-catenin
;
chromosome 3p
;
lung cancer
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Abstract β-Catenin has emerged as an important component of the adherens junctions between epithelial cells. As a result of studies of its interaction with theAPC gene product, it has been implicated in the development of colorectal cancer. α-Catenin, β-catenin, E-cadherin and APC appear to mediate contact inhibition in epithelia. As part of the study of the organization of the β-catenin gene, we have isolated yeast artificial chromosomes (YACs) to characterize its intron/exon structure. YAC fluorescencein situ hybridization analysis and polymerase chain reaction analysis of somatic cell hybrid DNAs show that β-catenin maps in the 3p21–22 region, the location of tumour-suppressor genes deleted in small-cell lung cancer (SCLC) and other disorders. β-Catenin YACs will provide a source of microsatellite markers useful in loss of heterozygosity studies to assess the importance of β-catenin deletions in SCLC.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00710714
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