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  • 1
    Electronic Resource
    Electronic Resource
    Posttraumatic spinal subarachnoid cyst (1996)
    Springer
    European radiology 6 (1996), S. 523-525 
    Details
    ISSN: 1432-1084
    Keywords: Myelographic CT ; MRI ; Spinal injury ; Subarachnoid cyst ; Spinal cord compression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A case of posttraumatic compressive subarachnoid cyst of the thoracic spine studied by MR, myelography, and myelo-CT is reported. This cyst was surgically confirmed and treated by shunting.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00182487
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  • 2
    Electronic Resource
    Electronic Resource
    Intracranial vascular involvement of brain pathologies and venous occlusions (1998)
    Springer
    European radiology 8 (1998), S. 1106-1115 
    Details
    ISSN: 1432-1084
    Keywords: Key words: Stroke ; Venous occlusions ; Computed tomography ; MRI ; Diffusion ; Echoplanar imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. In this paper, the authors present the contribution of CT and MRI to the diagnosis of acute stroke caused by arterial or venous occlusion. The term “early” used in this context means within 6 h of the onset of symptoms. Signs of early ischemic edema are subtle and sometimes difficult to detect by CT or MRI. The purpose of this presentation is to familiarize the clinician and the radiologist with the subtle brain parenchymal changes seen within the first 6 h after onset of symptoms, in order to improve detection of early ischemic infarction and to improve patient care.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003300050517
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  • 3
    Electronic Resource
    Electronic Resource
    Pharmacological and Biochemical Characterization of Rat Hippocampal 5-Hydroxytryptamine1A Receptors Solubilized by 3–[3–(Cholamidopropyl)dimethylammonio]-1-Propane Sulfonate (CHAPS) (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 51 (1988), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Rat hippocampal 5-hydroxytryptamine1A (5-HT1A) binding sites were solubilized with a yield of 34% using 3–[3–(cholamidopropyl)dimethylammonio]-1-propane sulfonate (CHAPS, 10 mM) as detergent. Kinetic analyses of [3H]8-hydroxy-2–(di-n-propylamino)tetralin ([3H]8-OH-DPAT) binding indicated that the 5-HT1A sites exhibit the same properties in the soluble form as in the membrane-bound form. Furthermore, a positive correlation (r= 0.988) was found between the respective pIC50 values of a series of agonists and antagonists to inhibit [3H]8-OH-DPAT binding to either soluble or membrane-bound 5-HT1A sites. Gel filtration through Sephacryl S-400 as well as chromatography on wheat germ agglutinin (WGA)-agarose did not affect the modulation by guanine nucleotides (5′-guanylylimidodi-phosphate) of [3H]8-OH-DPAT binding which suggests that the 5-HT1A binding subunit is a glycoprotein tightly attached to a G protein even in its soluble form. The [3H]8-OH-DPAT binding material eluted from Sephacryl S-400 had an apparent molecular mass of 155 kilodaltons, as expected from a heterodimer with one binding subunit (∼60 kilodaltons) and one G protein (∼80 kilodaltons). Marked enrichment in 5-HT1A binding sites relative to other soluble proteins was found in the peak fractions eluted from Sephacryl S-400 (by sixfold) and WGA-agarose (by 26-fold) columns, suggesting that these chromatographic steps might be of interest for the purification of central 5–HT1A receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1988.tb03064.x
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  • 4
    Electronic Resource
    Electronic Resource
    Basilar artery occlusion in a child: ”clot angioplasty” followed by thrombolysis (2000)
    Springer
    Child's nervous system 16 (2000), S. 496-500 
    Details
    ISSN: 1433-0350
    Keywords: Keywords Stroke ; Acute occlusion ; Basilar artery ; Cerebral arteries ; Angioplasty ; Thrombolysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Basilar artery occlusions are rare but have a very poor prognosis. Intra-arterial thrombolysis may produce recanalization and better clinical outcome. A short delay between the onset of symptoms and thrombolysis is considered essential for successful recanalization and for the smallest possible risk of haemorrhagic complications. We present a case of basilar artery occlusion in an 8-year-old child, which was treated by ”clot angioplasty” followed by intra-arterial thrombolysis. Thirty hours after progressive alteration of consciousness, speech disturbances and left arm paresis, the child became comatose with decerebrate rigidity. A CT scan showed parenchymal ischaemic lesions. Angiography (performed 36 h after the onset of symptoms) showed a total occlusion of the basilar artery. A clot angioplasty was performed by placing a balloon catheter within the thrombus and inflating it several times in the occluded segment of the basilar artery. Thrombolysis was then performed through the balloon catheter. The basilar artery was only partially recanalized at the end of the procedure, but the perforating arteries of the brain stem had reappeared on angiography. Three months later the child had completely recovered to a normal clinical status. In conclusion, the very poor natural prognosis of basilar artery occlusion requires aggressive management. Recanalization of the basilar artery may be performed even late after the onset of symptoms. Clot angioplasty allows partial recanalization, which may increase the efficiency of thrombolysis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003819900197
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  • 5
    Electronic Resource
    Electronic Resource
    Properties of calcium currents and contraction in cultured rat diaphragm muscle (1995)
    Springer
    Pflügers Archiv 430 (1995), S. 837-845 
    Details
    ISSN: 1432-2013
    Keywords: Diaphragm ; Excitation-contraction ; Cell culture ; Calcium currents ; Inactivation ; Patch-clamp
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The characterization of calcium currents and contraction simultaneously measured in cultured rat diaphragm muscle cells was carried out in the present study. Whole-cell patch-clamp experiments were designed to further elucidate the mechanism of excitation-contraction (E-C) coupling in diaphragm which, though generally considered a skeletal-type muscle, has been reported to exhibit properties indicative of a cardiac-like E-C coupling mechanism. Normalized current/voltage (I/V) curves for two concentrations of external calcium (2.5 and 5 mM) were obtained from diaphragm myoballs. Both curves showed peaks corresponding to the activation of a T-type calcium current and a dihydropyridine-sensitive L-type calcium current. The normalized curve for the voltage dependence of the activation of contraction in diaphragm myoballs followed a typical Boltzmann-type relationship to the peak of contraction. Thereafter, the curve declined in a manner that was more pronounced in diaphragm compared to that measured in additional experiments using cultured rat limb muscle myoballs. This effect could be interpreted in terms of a more pronounced participation of the L-type current in E-C coupling in cultured diaphragm muscle. An increased likelihood of cultured diaphragm muscle to undergo depletion of sarcoplasmic reticular calcium stores during repetitive stimulation, or a heightened propensity for the voltage sensor for E-C coupling in diaphragm to enter the inactive state could also explain this effect. Maximal contractile activity was only slightly affected when the L-type current was blocked by externally applied cadmium (2 mM) or cobalt (3 mM), suggesting that a pronounced calcium-current-dependent component of contraction is unlikely in cultured diaphragm muscle. These results show that T- and L-type calcium channels are expressed in cultured rat diaphragm muscle cells and that, in contrast to cardiac muscle, the entry of calcium ions via L-type voltage-dependent calcium channels is not a prerequisite for contraction. Differences in the voltage sensitivity of contraction, observed at depolarized membrane potentials in cultured rat diaphragm and limb muscle cells, suggest that the voltage sensor for E-C coupling in diaphragm might more readily enter an inactivated configuration — possibly by a mechanism which is dependent on the concentration of external calcium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00386184
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  • 6
    Electronic Resource
    Electronic Resource
    Reversal of the relative expression of cardiac and skeletal alpha1 subunit isoforms of L-type calcium channel during in vitro myogenesis (1996)
    Springer
    Pflügers Archiv 433 (1996), S. 376-378 
    Details
    ISSN: 1432-2013
    Keywords: Key words L-type calcium channel ; α1 subunit ; Skeletal muscle development ; Excitation-contraction coupling ; Cell culture
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Cardiac and skeletal type of excitation-contraction coupling (ECC) are quite different. Those differences could be explained by structural ones in the molecular entities involved in ECC, ie dihydropyridines (DHP) receptors (α1 subunit of L-type calcium channels) of the sarcolemma or ryanodine receptors of the sarcoplasmic reticulum membrane. As previously demonstrated by means of electrophysiology, the two types of ECC coexist during the first stages of in vitro development of skeletal muscle, whereas the skeletal type predominates at the later ones. In order to see whether evolution of ECC could be correlated with the one of α1 subunit expression, we determined by Northern Blotting which isoforms of α1 subunit are expressed during the in vitro myogenesis. mRNA corresponding to the cardiac isoform are present in myoblasts (before fusion), but patch-clamp experiments showed that they are not functional. After fusion, skeletal and cardiac mRNA are coexpressed in myotubes, with different intensities: whereas expression of skeletal mRNA (which are the more intensive) stabilized at the later stages tested, cardiac mRNA decreased. We conclude that evolution in mRNA α1 subunit isoforms expression could partly explained evolution of ECC features during in vitro myogenesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004240050291
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  • 7
    Electronic Resource
    Electronic Resource
    Acrylic vertebroplasty in symptomatic cervical vertebral haemangiomas: report of 2 cases (1996)
    Springer
    Neuroradiology 38 (1996), S. 389-391 
    Details
    ISSN: 1432-1920
    Keywords: Acrylic vertebroplasty ; Vertebral haemangioma ; Cervical spine ; Computed tomography ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report two cases of acrylic vertebroplasty in symptomatic cervical vertebral haemangiomas. In both cases significant improvement of symptoms was rapid. One patient was able to return to work.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00596600
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  • 8
    Electronic Resource
    Electronic Resource
    The role of CT in evaluation of the effectiveness of embolisation of spinal dural arteriovenous fistulae with N -butyl cyanoacrylate (1996)
    Springer
    Neuroradiology 38 (1996), S. 603-608 
    Details
    ISSN: 1432-1920
    Keywords: Key words Spinal arteriovenous malformations ; Dural arteriovenous fistula ; Dura mater ; Endovascular treatment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A failed embolisation of a spinal dural arteriovenous fistula (AVF), because a pedicular injection has not reached the initial venous compartment, must be identified immediately, to allow prompt surgery and thus avoid clinical deterioration. The purpose of our study was to determine the role of CT in confirming a complete cure just after embolisation with N -butyl cyanoacrylate (NBCA). Seven patients embolised for spinal dural AVFs with perimedullary venous drainage had an immediate postembolisation CT scan. In six patients a complete cure was achieved, with a normal postembolisation angiogram in five cases. Just after injection of NBCA, we were unable to determine on plain films whether or not the glue had reached the draining vein in six of seven cases. The postembolisation CT showed various patterns: in two cured patients, the glue was visible in the inner surface of the dura mater and therefore on the venous side. In five cases, the glue was approaching the dura mater around the cord or seemed to reach its surface: in the four patients cured, the glue column was 7–18 mm high, whereas it was less than 2 mm high in the patient with angiographic proof of recurrent fistula. The follow-up angiogram remains the only way to confirm a durable cure. We suggest that immediate postembolisation CT may help in assessing endovascular treatment of spinal dural AVFs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002340050317
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  • 9
    Electronic Resource
    Electronic Resource
    Acrylic vertebroplasty in symptomatic cervical vertebral haemangiomas: report of 2 cases (1996)
    Springer
    Neuroradiology 38 (1996), S. 389-391 
    Details
    ISSN: 1432-1920
    Keywords: Key words Acrylic vertebroplasty ; Vertebral haemangioma ; Cervical spine ; Computed tomography ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report two cases of acrylic vertebroplasty in symptomatic cervical vertebral haemangiomas. In both cases significant improvement of symptoms was rapid. One patient was able to return to work.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00596600
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  • 10
    Electronic Resource
    Electronic Resource
    Intracranial dural arteriovenous fistulae with perimedullary venous drainage. Anatomical, clinical and therapeutic considerations (1999)
    Springer
    Neuroradiology 41 (1999), S. 803-812 
    Details
    ISSN: 1432-1920
    Keywords: Key words Fistula ; arteriovenous ; dural ; Spinal cord ; Embolisation ; Dysautonomia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report five cases of intracranial dural arteriovenous fistula (DAVF) with perimedullary venous drainage. All the patients presented with rapidly progressive myelopathy and three had autonomic disorders. The DAVF were on the tentorium cerebelli (two cases), sigmoid (one), superior petrosal (one), and cavernous sinus (one). Slow venous drainage was directed through dilated perimedullary cervical veins. The transverse sinus was occluded in two cases. MRI, performed in four cases, demonstrated high signal on T2-weighted spin-echo sequences in the medulla oblongata and upper cervical spinal cord consistent with oedema, which signal resolved after complete cure of the DAVF in three cases. Embolisation was performed in all cases. It was followed by clinical deterioration in two cases and in the dramatic improvement in the other three, with complete clinical cure in two. Extensive venous thrombosis may explain the deterioration observed in one case.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002340050846
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