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  • 1
    Electronic Resource
    Electronic Resource
    Non-specific esterase in cerebral tumors (1968)
    Springer
    Acta neuropathologica 10 (1968), S. 143-150 
    Details
    ISSN: 1432-0533
    Keywords: Brain tumors ; Enzyme histochemistry ; Non-specific esterase ; E 600 inhibition of esterase activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In 45 neurochirurgisch gewonnenen Hirntumoren wurde die unspezifische Esterase histochemisch untersucht. Verschiedene Substrate und Kuppler wie auch mehrere Effektoren wurden verwendet. Die E 600-resistente Enzymaktivität verhält sich wie saure Phosphatase und erscheint in Beziehung zu den katabolischen oder regressiven Vorgängen zu stehen. Dies erklärt auch ihre hohe Aktivität in anaplastischen Tumoren. Auch die E 600-empfindliche Enzymaktivität erhöht sich mit der Malignität, sie scheint aber eher in Beziehung zum Plasmavolumen zu stehen. Die verschiedenen Geschwulstarten und Zelltypen werden im Lichte der erhaltenen Befunde diskutiert.
    Notes: Summary Non-specific esterase has been histochemically studied in 45 cerebral tumors of neurosurgical source. Different substrates and couplers as well as several effectors have been used. The E 600-resistant enzyme activity behaves like acid phosphatase and appears to be in relation with the catabolic or regressive occurrences. This association explains its high value in anaplastic tumors. Also the E 600-sensitive enzyme activity increases with malignancy, but it appears rather in relation with the volume of the cytoplasms. The different oncotypes and cytotypes are discussed in the light of the obtained results.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691308
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  • 2
    Electronic Resource
    Electronic Resource
    On the nature of the lymphocyte-like cells of medulloblastomata (1966)
    Springer
    Acta neuropathologica 6 (1966), S. 290-297 
    Details
    ISSN: 1432-0533
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Um das Wesen der Lymphocyten-ähnlichen Kerne im Medulloblastom aufzuklären, wurden 46 Tumoren histologisch und histochemisch untersucht. Es lassen sich 3 Typen dieser Kerne unterscheiden: im Tumor eingeschlossene cerebellare Körnerzellen, Kerne vom nekrotischen Typ, die in kleinen Herden gehäuft auftreten, und Kerne vom nicht-nekrotischen Typ. Letztere werden mit pathologischen, die Mitosen beeinflussenden Vorgängen in Beziehung gebracht und dürften verschiedene Stadien derselben darstellen. Das Auftreten pathologischer Mitosen, wie es bei einem rasch wachsenden Tumor zu erwarten ist, wird in diesem Zusammenhang hervorgehoben.
    Notes: Summary In order to elucidate the nature of the lymphocyte-like nuclei in medulloblastomata, 46 tumours have been histologically and histochemically investigated. 3 types of these nuclei can be distinguished: granule cells of the cerebellum included in the tumour; nuclei of necrotic type grouped in small foci; and nuclei of nonnecrobiotic type. The latter are considered to be the result of pathological processes affecting mitoses and to represent the different stages of these processes. In this regard the presence of abnormal mitoses in medulloblastoma is emphasized, as they must be expected in a rapidly growing tumour.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687859
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  • 3
    Electronic Resource
    Electronic Resource
    A histochemical study on the distribution and localization of Beta-glucuronidase activity in cerebral tumors (1969)
    Springer
    Acta neuropathologica 13 (1969), S. 91-96 
    Details
    ISSN: 1432-0533
    Keywords: Brain Tumors ; Enzyme Histochemistry ; Beta-Glucuronidase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Aktivität der Beta-Glucuronidase wurde in 46 Hirngeschwülsten mittels Naphthol-AS-BI-beta-D-Glucuronid und diazotiertem Pararosanilin untersucht. Das Verteilungsmuster der Enzymaktivität ist ähnlich dem bereits für andere lysosomale Enzyme beobachteten, zeigt aber leichte Abweichungen. Die histochemische Anfärbung nimmt in regressiven und katabolen Gebieten zu, so daß eine indirekte Beziehung zur Malignität zu bestehen scheint. Besonderes Augenmerk wird einigen Zelltypen zugewandt, wie den Riesenzellen im Glioblastom sowie gemästeten Astrocyten, deren hohe Enzymaktivität als Zeichen einer regressiven Zellreaktion gewertet wird.
    Notes: Summary Beta-glucuronidase activity has been studied in 46 cerebral tumors by Naphthol AS-BI beta-D-glucuronide and diazotized pararosanilin. The distribution pattern of the enzyme activity is similar to that already observed for other lysosomal enzymes, with some minor differences. The histochemical staining increases in regressive or catabolic areas so that its relationship with malignancy appears to be indirect. Special regard is devoided to some cytotypes, such as giant cells of glioblastoma and gemistocytic astrocytes whose high enzyme activity is considered as a sign of cellular regression.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00686143
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  • 4
    Electronic Resource
    Electronic Resource
    Epileptic seizures and lipoma of the corpus callosum (1982)
    Springer
    Neurological sciences 3 (1982), S. 139-142 
    Details
    ISSN: 1590-3478
    Keywords: Lipoma ; corpus callosum ; carbamazepine ; camazepam AED/plasma levels
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario Viene riferito il caso di un paziente affetto da lipoma del corpo calloso. L'osservazione sembra interessante perché, a differenza dei dati riferiti in letteratura, il paziente presentava sia crisi parziali complesse che originavano dal lato fronto-temporale sinistro che crisi toniche emigeneralizzate. Il controllo clinico delle crisi fu ottenuto solo dopo l'aggiunta di Camazepam. L'episodica insorgenza di visione annebbiata e diplopia esclusivamente nelle ore serali, è stata riferita a picchi ritardati della concentrazione plasmatica di Carbamazepina superiori a 12 ug/ml e scomparve dopo una.riduzione di modesta entità della dose giornaliera del farmaco.
    Notes: Abstract This case of lipoma of the corpus callosum is interesting because, unlike others reported in the literature, the patient presented both complex partial seizures arising from the left fronto-temporal region and generalized rightsided tonic seizures, clinically controlled only after the administration of Camazepam. Episodic blurred vision and diplopia in the afternoon were caused by late peak plasma levels of Carbamazepine (CBZ) above 12 μg/ml and disappeared after a minimal reduction of the CBZ daily dose.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02043947
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  • 5
    Electronic Resource
    Electronic Resource
    Single photon emission computed tomography with99mTc HM-PAO in the study of focal epilepsy (1989)
    Springer
    Neurological sciences 10 (1989), S. 175-179 
    Details
    ISSN: 1590-3478
    Keywords: Spect ; focal epilepsy ; rCBF ; PET
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario Sono stati studiati mediante SPECT con99mTc HM-PAO 50 pazienti affetti da epilessia parziale, 47 in fase intercritica e 3 durante la crisi. Tutti i pazienti registrati in fase critica hanno dimostrato un focolaio di iperfissazione del tracciante. Tra quelli registrati in fase intercritica 35 (74%) hanno evidenziato asimmetrie di perfusione di cui 27 (57%) ipofissanti ed 8 (17%) iperfissanti. I risultati sono discussi e confrontati con quelli di analoghi lavori condotti mediante tomoscintigrafia e tomografia a positroni.
    Notes: Abstract We used99mTc HM-PAO SPECT to study 50 patients with partial epilepsy: 47 interically and 3 during a seizure. All 3 patients studied during a seizure presented an area of increased tracer uptake. Of those in whom recordings were taken during seizure-free intervals 35 (74%) showed perfusion asymmetries: 27 (57%) with decreased and 8 (17%) with increased uptake. We discuss the findings and compare them with those of similar studies using SPECT and positron emission tomography.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02333615
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    Paper (German National Licenses)
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