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  • 1
    Electronic Resource
    Electronic Resource
    Testosterone effect on experimental diabetes mellitus in encephalomyocarditis (EMC) virus infected mice (1980)
    Springer
    Diabetologia 18 (1980), S. 247-249 
    Details
    ISSN: 1432-0428
    Keywords: Encephalomyocarditis virus ; diabetes ; testosterone ; mice ; immunological reactive insulin ; islets of Langerhans
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A diabetes mellitus-like disease occurs in male DBA/2 mice infected with the M variant of the encephalomyocarditis virus. Female mice of this strain sustain systemic infection, but rarely exhibit hyperglycaemia. The diabetogenic effects of the virus were studied in 3 groups of adult DBA/2 males-castrates, castrates treated with testosterone, and sham-operated controls. After infection, pancreatic insulin concentrations decreased precipitously to approximately 10% of control values in intact males and castrates treated with testosterone; hyperglycaemia occurred concomitantly in both groups. In contrast, untreated castrates failed to develop hyperglycaemia and the effect on the insulin content of the pancreas was less striking.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00251924
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of interferon on encephalomyocarditis virus infection of cultured mouse pancreatic B cells (1983)
    Springer
    Diabetologia 24 (1983), S. 38-41 
    Details
    ISSN: 1432-0428
    Keywords: Encephalomyocarditis virus ; interferon ; diabetes ; B cell monolayer culture
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The M variant of encephalomyocarditis virus (EMC) produces a disease similar to human insulin-dependent diabetes mellitus in some but not all strains of mice. This diabetogenic M variant was found to induce fivefold more interferon than non-diabetogenic strains of EMC in cultures of mouse L 929 fibroblasts. When interferon induced by the M variant was added to monolayers of B cells from both diabetes-‘susceptible’ CD-1 mice and ‘resistant’ C57 bl/6 mice before EMC infection, B cell damage and virus replication were delayed. In addition, viral production in B cell cultures from C57 bl/6 mice was reduced five-to tenfold. A similar effect was not found when cultures from CD-1 mice were treated with interferon. Thus, interferon might play an important role in modulating the severity of the initial infection of B cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00275945
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Lesions of renal glomeruli in mice with virus-induced diabetes mellitus-like disease (1973)
    Springer
    Diabetologia 9 (1973), S. 203-209 
    Details
    ISSN: 1432-0428
    Keywords: Encephalomyocarditis virus ; Virus-induced diabetes ; Diabetic renal lesion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Encephalomyocarditis (EMC) virus infected DBA/2 mice develop a diabetes mellitus-like disease. Many animals survive the acute viral infection and exhibit hyperglycemia and glycosuria for varying periods thereafter. Accumulations of homogeneous, electron dense, basement membrane-like material are observed in the mesangium of the glomerulus of these animals as early as three months after inoculation. The peripheral capillary basement membranes are not affected. Since the alterations are not found in uninfected animals, it is assumed that the abnormal metabolic state or the virus infection, or both processes, are responsible for the glomerular changes. Further investigation will be required to elucidate the pathogenesis of this obscure lesion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01219784
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Necrosis of the Pancreas, Parotid and Lachrymal Glands Associated with Encephalomyocarditis Virus Infection (1965)
    [s.l.] : Nature Publishing Group
    Nature 207 (1965), S. 1268-1269 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] RECENT studies in this laboratory have been concerned with the pathogenicity for animals of selected, antigenically similar strains of encephalomyocarditis (EMC) virus. During the course of this work, necrosis of the adipose tissue of the retroperitoneum and epididymal fat tags was noted in adult ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/2071268a0
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Encephalomyocarditis virus infection of cultured murine pancreatic β - cells (1980)
    [s.l.] : Nature Publishing Group
    Nature 285 (1980), S. 112-113 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The majority of cells in our monolayer cultures stained positively by an immunoperoxidase technique8,9 using anti-bovine insulin serum. The cultures secreted insulin into the medium at a gradually increasing rate for periods of longer than 1 month10,11. However, because the monolayers were prepared ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/285112a0
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  • 6
    Electronic Resource
    Electronic Resource
    Encephalomyocarditis virus induced diabetes mellitus in mice: Long-term changes in the structure and function of islets of langerhans (1983)
    Springer
    Diabetologia 25 (1983), S. 39-44 
    Details
    ISSN: 1432-0428
    Keywords: Encephalomyocarditis virus ; islets of Langerhans ; insulin and glucagon metabolism ; morphological ; mouse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Adult male mice infected with the M variant of encephalomyocarditis virus develop hyperglycaemia acutely as a consequence of B cell injury. The severity of the metabolic disease is variable and many animals become normoglycaemic during convalescence. The islets of Langerhans of these mice exhibit minor structural changes, but there are no significant abnormalities of insulin and glucagon secretion. In contrast, animals with persistent hyperglycaemia exhibit striking morphological alterations in the islets. The A cell mass is prominent, whereas B cells are reduced in number and exhibit striking cytological features. These changes are associated with both hypoinsulinaemia and hyperglucagonaemia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00251895
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Cytological studies on cytomegalovirus infected mouse cells (1969)
    Springer
    Archives of virology 26 (1969), S. 334-340 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Cytomegalovirus infection of mouse embryonic fibroblasts inhibited mitosis and induced chromosome aberrations. These effects were observed late in the course of infection at a time when cytopathic effect and extracellular virus production were evident in the cell cultures. The changes occurred within a single cell division cycle and appeared irreversible.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01250943
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    Paper (German National Licenses)
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