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  • 1
    Electronic Resource
    Electronic Resource
    Comparison of the antinociception produced by two oral formulations of ibuprofen: ibuprofen effervescent vs ibuprofen tablets (1997)
    Springer
    European journal of clinical pharmacology 52 (1997), S. 107-114 
    Details
    ISSN: 1432-1041
    Keywords: Key words Nociception ; Ibuprofen; irritation ; anal-gesia ; human ; NSAID
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Objective: The aim of this study was to compare the dose-related effects of both ibuprofen tablets and ibuprofen effervescent [placebo, 400 and 800 mg ibuprofen (Aktren)] on phasic pain. Patients: Twenty volunteers participated in this randomized, double-dummy, fivefold crossover study. Methods: Measurements were obtained before and 15, 60 and 240 min after drug administration. Pain was produced by CO2 pulses applied to the left nostril. Subjects rated the intensity of the painful stimuli by means of a visual analogue scale. In addition, chemosomatosensory event-related potentials were recorded. Results: In line with previous work, ibuprofen produced a dose-related decrease in pain-related potential amplitudes P1N1, indicating its antinociceptive effects. Higher plasma concentrations of ibuprofen were reached 15–40 min after administration of the effervescent while ibuprofen tablets had a tmax 60–90 min after administration. In addition, 60 min after intake of the effervescent a prolongation of the latencies of the potentials was observed, possibly reflecting superior antinociceptive properties when compared to ibuprofen tablets. In addition, the effervescent appeared to have more consistent effects on intensity estimates compared to ibuprofen tablets.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002280050258
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  • 2
    Electronic Resource
    Electronic Resource
    First observations of Pontecorvo reactions with a recoiling neutron (1995)
    Springer
    The European physical journal 351 (1995), S. 325-331 
    Details
    ISSN: 1434-601X
    Keywords: 25.43
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract We report the first observations of Pontecorvo reactions of the type ¯pd →Xn. We fully reconstruct the outgoing meson and, for antiprotons stopped in liquid deuterium, we measure: BR(¯pd→π0)=(7.03±0.72)×10−6, BR(¯pd→ηn)=(3.19+0.48)×10−6, BR(¯pd→ωn)=(22.8+4.1)×10−6, BR(¯pd→η′n)14×10−6 (at 95% confidence level). Assuming charge independence, our result for¯ pd→π0n is compatible with measurements of the only other observed Pontecorvo reaction ¯pd → π−p. The experimental ratios between the above branching ratios are in fair agreement with both the statistical model and dynamical two-step models (assumingN¯ N annihilation into two mesons, with subsequent absorption of one meson on the remaining nucleon). This agreement suggests that there may be appreciable rates for Pontecorvo reactions producing final state mesons with masses above 1 GeV.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01290916
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    Paper (German National Licenses)
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