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  • 1
    Electronic Resource
    Electronic Resource
    Plasma protein binding of the enantiomers of hydroxychloroquine and metabolites (1993)
    Springer
    European journal of clinical pharmacology 44 (1993), S. 481-484 
    Details
    ISSN: 1432-1041
    Keywords: Hydroxychloroquine ; enantiomers ; protein binding ; metabolites
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The in vitro binding of the enantiomers of hydroxychloroquine and its three major metabolites in pooled plasma obtained from four healthy volunteers and the binding of the enantiomers of hydroxychloroquine to purified plasma proteins has been investigated. The plasma protein binding of hydroxychloroquine was found to be stereoselective. The (S)-enantiomer of hydroxychloroquine was 64% bound in plasma, while (R)-hydroxychloroquine was 37% bound. Fifty % of (S)-hydroxychloroquine was bound to a 40 g·l−1 solution of human serum albumin, while only 29% of the (R)-enantiomer was bound. The enantioselectivity of hydroxychloroquine binding was reversed in a 0.7 g·l−1 solution of α1-acid glycoprotein with (R)-hydroxychloroquine being bound to a greater extent than its optical antipode (41% versus 29%). The enantiomers of the metabolites of hydroxychloroquine were bound to a similar extent to plasma and purified plasma proteins. Binding of hydroxychloroquine to plasma and purified proteins was found to be linear over the racemic concentration range of 50 to 1000 ng·ml−1 and hydroxychloroquine metabolite binding to plasma was linear over the range 25 to 500 ng·ml−1.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315548
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  • 2
    Electronic Resource
    Electronic Resource
    Apparent dose-dependence of chloroquine pharmacokinetics due to limited assay sensitivity and short sampling times (1987)
    Springer
    European journal of clinical pharmacology 31 (1987), S. 729-731 
    Details
    ISSN: 1432-1041
    Keywords: chloroquine ; pharmacokinetics ; dose-dependence ; exponential equations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary We have shown that apparent nonlinearities in the pharmacokinetics of chloroquine and wide variability in reported kinetic values are possibly artefacts of experimental design. We have used simulated data based on linear equations to demonstrate that chloroquine kinetics may appear to be dose-dependent if samples are collected over a short period or if they are assayed with a method of low sensitivity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00541305
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  • 3
    Electronic Resource
    Electronic Resource
    Comparative analyses of multi-species sequences from targeted genomic regions (2003)
    [s.l.] : Macmillian Magazines Ltd.
    Nature 424 (2003), S. 788-793 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The systematic comparison of genomic sequences from different organisms represents a central focus of contemporary genome analysis. Comparative analyses of vertebrate sequences can identify coding and conserved non-coding regions, including regulatory elements, and provide insight into the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature01858
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  • 4
    Electronic Resource
    Electronic Resource
    Effects of Vasoactive Intestinal Polypeptide on Neurones of the Rat Suprachiasmatic Nuclei In Vitro (2002)
    Oxford, UK : Blackwell Science Ltd
    Journal of neuroendocrinology 14 (2002), S. 0 
    Details
    ISSN: 1365-2826
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The suprachiasmatic nuclei (SCN) of the hypothalamus house the main circadian pacemaker in mammals. Vasoactive intestinal polypeptide (VIP) is the most abundant neuropeptide in the SCN and has been shown to phase-shift the electrical activity rhythm of SCN cells in vitro. However, the effects of VIP on the cellular activity of rat SCN neurones are unknown. In this study, we examined the acute effects of VIP on the extracellularly recorded spontaneous firing rate of SCN neurones in an in-vitro hypothalamic slice preparation. Furthermore, with the use of receptor-selective agonists and antagonists, we determined which receptors might mediate the effects of VIP in the SCN. Approximately 50% of cells responded to VIP; the main type of response was suppression in firing rate, although a few cells were activated. Suppression responses to VIP were mimicked by the VPAC2 receptor agonist Ro 25-1553 and blocked by the selective VPAC2 receptor antagonist PG 99-465. The PAC1 receptor agonist maxadilan evoked responses from 40% of SCN cells, and activations to this agonist were not altered by PG 99-465. Responses to VIP were not blocked by antagonists to ionotropic glutamate receptors, but the duration of suppression was modulated by the GABAA receptor antagonist bicuculline. Our data indicate that VIP alters the electrical activity of rat SCN neurones in vitro, via both VPAC2 and PAC1 receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2826.2002.00826.x
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  • 5
    Electronic Resource
    Electronic Resource
    Observation of terrestrial orbital motion using the cosmic-ray Compton–Getting effect (1986)
    [s.l.] : Nature Publishing Group
    Nature 322 (1986), S. 434-436 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Compton and Getting1 showed that a cosmic-ray detector with an energy threshold would observe an enhanced intensity when it moved along its direction of maximum sensitivity with respect to the rest frame of the cosmic-ray plasma. If the cosmic-ray energy distribution were a power law of the form ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/322434a0
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  • 6
    Electronic Resource
    Electronic Resource
    Linear polyethylene in a glassy phase: The value of the glass-transition temperature (1979)
    New York : Wiley-Blackwell
    Journal of Polymer Science: Polymer Physics Edition 17 (1979), S. 907-915 
    Details
    ISSN: 0098-1273
    Keywords: Physics ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Raman spectroscopy, x-ray diffraction, and thermal analysis are used to investigate the structure of linear high-density polyethylene rapidly quenched from the melt to cryogenic temperatures. All the results point to the production of a glassy phase which crystallizes when heated above 170 K.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pol.1979.180170601
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  • 7
    Electronic Resource
    Electronic Resource
    Use of optical fibres in Raman spectroscopy (1988)
    Chichester [u.a.] : Wiley-Blackwell
    Journal of Raman Spectroscopy 19 (1988), S. 413-418 
    Details
    ISSN: 0377-0486
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: A detailed study of the parameters governing the design of an optical fibre system for use in Raman spectroscopy is described. The results have led to the design and construction of a flexible fibre optic remote sampling system which is easily adaptable for use on most commercial instruments. A variety of samples were used to evaluate the performance of the system and have been classified in terms of the efficiency of the new technique relative to more conventional methods of excitation and collection.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jrs.1250190607
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  • 8
    Electronic Resource
    Electronic Resource
    An observation of resonance Raman in the near-infrared (1990)
    Chichester [u.a.] : Wiley-Blackwell
    Journal of Raman Spectroscopy 21 (1990), S. 699-702 
    Details
    ISSN: 0377-0486
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The NIR FT Raman spectrum of bacteriorhodopsin is reported. By comparison with previously published spectra it appears that there is some degree of resonance enhancement. Also reported is the spectrum of a sample of blue dyed cotton. Resonance enhancement is proposed to explain strong features in the spectrum not present in either undyed or red dyed material.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jrs.1250211011
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  • 9
    Electronic Resource
    Electronic Resource
    A new multichannel Raman optical activity instrument (1987)
    Chichester [u.a.] : Wiley-Blackwell
    Journal of Raman Spectroscopy 18 (1987), S. 281-287 
    Details
    ISSN: 0377-0486
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: A fully computer-controlled Raman optical activity spectrometer equipped with an intensified diode array detector is described. Despite using a conventional single-lens light collection system for simplicity, both polarized and depolarized Raman optical activity spectra can be obtained rapidly and routinely. A novel double grating spectrograph design permits good spectra to be obtained down to 50 cm-1 in liquids. Natural spectra of the chiral samples (-)-α-pinene and (+)-methylcyclohexanone and magnetic spectra of iridium (IV) hexachloride are presented.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jrs.1250180410
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