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Apparent dose-dependence of chloroquine pharmacokinetics due to limited assay sensitivity and short sampling times (1987)

Tett, S. E. ; Cutler, D. J.

Springer

European journal of clinical pharmacology 31 (1987), S. 729-731

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ISSN: 1432-1041

Keywords: chloroquine ; pharmacokinetics ; dose-dependence ; exponential equations

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary We have shown that apparent nonlinearities in the pharmacokinetics of chloroquine and wide variability in reported kinetic values are possibly artefacts of experimental design. We have used simulated data based on linear equations to demonstrate that chloroquine kinetics may appear to be dose-dependent if samples are collected over a short period or if they are assayed with a method of low sensitivity.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00541305

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