ISSN:
1433-0350
Keywords:
Key words Herpes simplex encephalitis
;
Single photon emission computed tomography
;
99mTc-ethyl cysteinate dimer
;
99mTc-d
;
l-hexamethyl-propylene-amine oxime
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract In herpes simplex encephalitis (HSE), the authors noted an evident dissociation between the 99mTc-ethyl cysteinate dimer (ECD) and 99mTc-d,l-hexamethyl-propylene- amine oxime (HMPAO) single photon emission computed tomographies (SPECTs). The patient was a 5-year-old boy with diffuse type of pontine glioma, which was treated with hyperfractionated radiotherapy. Two weeks after the completion of radiation therapy, a lesion suggesting that of HSE was noted in the right frontotemporal region on magnetic resonance images. 99mTc-HMPAO SPECT showed an increased accumulation of the tracer in this lesion. On the 99mTc-ECD dynamic SPECT, an exaggerated accumulation of the tracer was noted within 80 s of administration, followed by a rapid drop in the accumulation, resulting in a low accumulation in 10 min. It was assumed that this dissociation was due to the different mechanisms to trap HMPAO and ECD in the brain tissue.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s003810050096
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