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  • 1
    Electronic Resource
    Electronic Resource
    ON THE ELIMINATION AND QUANTITATIVE ESTIMATION OF WATER IN OILS, FATS, AND WAXES. (1901)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 23 (1901), S. 487-488 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja02033a012
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    A NEW FORM OF ALKALIMETER. (1902)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 24 (1902), S. 391-392 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja02018a012
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  • 3
    Electronic Resource
    Electronic Resource
    Ground Water Monitoring Statistics Update: Part I: Progress Since 1988 (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Ground water monitoring & remediation 14 (1994), S. 0 
    Details
    ISSN: 1745-6592
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geosciences
    Notes: Current federal ground water monitoring statistical regulation dates from the revised RCRA Subtitle C Final Rule of 1988. That rule was a considerable advance over previous RCRA statistical rules. However, two major problem areas remained: facility-wide false positive rate (FWFPR) control and spatial variability. Progress has been made in the 1991 Subtitle D Final Rule and in guidance: the 1992 Addendum to Interim Final Guidance in particular includes a substantial conceptual advance toward resolving the FWFPR problem. Other areas of improvement include normality testing and distribution assumptions, dropping the four independent samples per monitoring period requirement, allowing a preliminary evaluation short of a 40 CFR Part 258 Appendix II assessment upon finding a statistically significant increase, and suggesting superior alternatives to analyses of variance (ANOVAs) and tests of proportions.The problem of dealing with natural spatial variability remains. Although certain techniques listed in the regulations can control for inherent spatial variability and the performance standards require doing so “when necessary,” little attention has been paid to the ubiquity of such spatial variation. Moreover, regulatory traditions favoring upgradient-downgradient comparisons often make control of natural spatial variation difficult and ineffective. With new. lined facilities easily implemented statistical solutions are available; however, dealing with the several existing solid waste facilities which will now be regulated under Subtitle D will present major challenges.In short, the 1988 revision of the Subtitle C rules made it more possible to provide statistically sound monitoring programs, and there has been steady progress since then. Challenges remain, however. These vary from slate to slate, particularly with regard to controlling false positives and false negatives in the presence of natural spatial variability.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1745-6592.1994.tb00493.x
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  • 4
    Electronic Resource
    Electronic Resource
    Potentials of average force for an interaction site model of aqueous alcohols: a molecular model for the hydrophobic bond (1988)
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 92 (1988), S. 6386-6399 
    Details
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/j100333a041
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  • 5
    Electronic Resource
    Electronic Resource
    On a Starch-Forming Enzyme from Malt: Its Action on Hemicelluloses and Its Commercial Application to Brewing. (1915)
    s.l. : American Chemical Society
    Industrial & engineering chemistry 7 (1915), S. 115-118 
    Details
    ISSN: 1520-5045
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ie50074a009
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  • 6
    Electronic Resource
    Electronic Resource
    Statistical Issues and Problems in Ground Water Detection Monitoring at Hazardous Waste Facilities (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Ground water monitoring & remediation 8 (1988), S. 0 
    Details
    ISSN: 1745-6592
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geosciences
    Notes: Ground water monitoring presents interesting statistical challenges, including controlling the risk of entering compliance monitoring, incorporating all modes of inherent variability into the statistical model on which tests are based, and taming the detection limit problem, all while maintaining demonstrable sensitivity to real contamination.Some of these challenges exceed textbook statistics considerably, even when considered alone, and good solutions are scarce. When these challenges are combined, the task of developing good statistical procedures or good regulations can be formidable.This article presents a number of realities of ground water monitoring that should be considered when developing statistical procedures. Recommendations made for addressing these realities include the following: (1) the false positive rate should be controlled on a facility-wide basis, rather than per well or per parameter as required in the proposed regulation (40 CFR §264); (2) multiple comparisons with control procedures are preferable to analysis of variance (ANOVA) for controlling the overall false positive rate; (3) retests can be made an explicit part of the statistical procedure in order to increase power and decrease sensitivity to distribution shape assumptions; (4) commonly used simple methods of handling below detection limit data with parametric tests, including Cohen's procedure as implemented in the U.S. EPA's Technical Enforcement Guidance Document (TEGD), should probably be avoided; (5) the statistical properties of practical quantitation limits for non-naturally occurring compounds should be studied carefully; and (6) so long as the facility-wide false positive rate is controlled, better sensitivity to real contamination is obtained by monitoring fewer well-chosen parameters at a smaller number of well-chosen locations.An evaluation of the proposed revised §264 regulation with respect to these realities reveals that it seems to be a definite improvement over the current regulation, but that it may be quite difficult to develop an adequate statistical plan within its constraints.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1745-6592.1988.tb01113.x
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  • 7
    Electronic Resource
    Electronic Resource
    Ground Water Monitoring Statistics Update: Part II: Nonparametric Prediction Limits (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Ground water monitoring & remediation 14 (1994), S. 0 
    Details
    ISSN: 1745-6592
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geosciences
    Notes: Nonparametric prediction limits can be useful statistical tools for ground water monitoring at facilities regulated under RCRA Subtitle C. Subtitle D. and similar regulations. New, exact tables arc presented for both “1 of m” plans (m chances to gel one observation inbounds at each of r monitoring wells to avoid a statistically significant increase) and “California” plans (first or all of the next m-1 observations inbounds at each well). The tables provide per-constituent significance levels (false positive rates) as a function of the background sample size n. m. r, the prediction limit (the largest or the next to largest, background observation), and the confirmatory resampling plan selected.When used in a monitoring program, future observations from several wells are compared with a prediction limit obtained from a common background sample. The table significance levels therefore depend critically on having IID (independent and identically distributed) observations. In particular, the false positive rate computations are not valid, and the procedures should not be used, with constituents whose measurements exhibit inherent spatial or systematic temporal variability.Recent U.S. EPA guidance explicitly encourages controlling facility-wide false positive rates over both constituents and wells. Nonparametric prediction limits, particularly with California resampling plans, will have greater difficulty in meeting the new. lower per-constituent false positive rate goals than previous ones, especially if many constituents are involved. Nonetheless, nonparametric prediction limits remain superior to other commonly used procedures for dealing with data with high proportions of nondctects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1745-6592.1994.tb00494.x
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  • 8
    Electronic Resource
    Electronic Resource
    DISCUSSION OF PAPERS (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Ground water 26 (1988), S. 0 
    Details
    ISSN: 1745-6584
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geosciences
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1745-6584.1988.tb00800.x
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  • 9
    Electronic Resource
    Electronic Resource
    DISCUSSION OF “Statistical Prediction Intervals for the Evaluation of Ground-Water Quality,” by Robert D. Gibbons, July-August 1987 issue, v. 25, no. 4, pp. 455–465 (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Ground water 26 (1988), S. 0 
    Details
    ISSN: 1745-6584
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geosciences
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1745-6584.1988.tb00373.x
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  • 10
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of a Hematoregulatory Peptide (SK&F 107647) in Healthy Male Volunteers and in Patients with Colorectal or Pancreatic Adenocarcinoma Not Amenable to Standard Therapy (2000)
    Springer
    Pharmaceutical research 17 (2000), S. 385-390 
    Details
    ISSN: 1573-904X
    Keywords: SK&F 107647 ; peptide ; pharmacokinetics ; hematore gulatory ; adenocarcinoma ; cytokines
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Purpose. To describe the pharmacokinetics of SK&F 107647, a synthetichematoregulatory peptide, in healthy volunteers and in patientswith adenocarcinoma.Methods. SK&F 107647 pharmacokinetics were evaluated in 2dose-escalation studies. Volunteers received SK&F 107647 as single15-minute iv infusion doses of 1, 10, 100, 500, and 1000 μg/kg. Cancerpatients received 2-hour iv infusions of 0.001, 0.01, 0.1 and 1μg/kg once daily for 10 days. Drug concentrations were quantified in plasmaand urine of healthy volunteers and on days 1 and 10 in plasma ofcancer patients receiving the two top dose levels.Results. In volunteers, mean clearance (CL) ranged from 76.7 to 101ml/hour/kg; mean volume of distribution at steady-state (Vss)rangedfrom 175 to 268 ml/kg. Most of the administered dose was renallyexcreted as intact peptide within 24 hours postinfusion. In patients,mean CL was 57.6 ml/hour/kg, mean Vss ranged from 128 to 150ml/kg and terminal half-life from 2.1 to 3.4 hours. There was littleaccumulation of drug. In both studies, linear pharmacokinetics wasobserved. Clearance approached normal glomerular filtration rate(GFR) in volunteers and correlated with creatinine clearance incancer patients.Conclusions. SK&F 107647 exhibits linear pharmacokinetics, a smallVss, and clearance, primarily renal, approaching normal GFR.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1007512617139
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