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  • 1
    Electronic Resource
    Electronic Resource
    Diagnosis and treatment of iron overload in paediatric patients on chronic haemodialysis (1988)
    Springer
    Pediatric nephrology 2 (1988), S. 303-308 
    Details
    ISSN: 1432-198X
    Keywords: Desferrioxamine ; Haemochromatosis ; Dialysis ; Children ; Ferritin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In this study the incidence and contributing factors of iron overload in paediatric patients treated with intermittent haemodialysis were evaluated. Particular attention was given to the diagnostic value of serum ferritin in the assessment of body iron stores in patients with hepatocellular damage. The results of treatment of secondary haemosiderosis with desferrioxamine (DFO) are reported. Serum ferritin levels were measured in 18 children and adolescents undergoing long-term haemodialysis; 8 of these had biochemical evidence of hepatocellular damage. In all patients a good correlation was found between serum ferritin levels and the amount of iron stored in the reticuloendothelial system. Six patients developed iron overload. Patients with secondary haemosiderosis were younger at the start of haemodialysis and received significantly more blood. Although not significant, more patients with haemochromatosis-associated alleles and bilateral nephrectomy had iron overload, and the duration of dialysis was obviously longer for overloaded patients (40 months versus 26 months). The patients with iron overload were treated with DFO. The data from all patients showed that DFO was ineffective when administered at a dose of 25 mg/kg during dialysis and that in individual patients changes in serum ferritin correlated with changes in the amount of blood transfusions administered.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00858682
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The Aase syndrome (1986)
    Springer
    European journal of pediatrics 145 (1986), S. 153-157 
    Details
    ISSN: 1432-1076
    Keywords: Aase syndrome ; Hypoplastic anaemia ; Erythropoietic precursor ; Triphalangeal thumbs ; Cleft lip/palate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A 5-month-old boy with congenital hypoplastic anaemia and triphangeal thumbs, known as the Aase syndrome, is described. In addition he had unilateral cleft lip and palate and abnormal dermatoglyphics. Only ten cases have been reported previously; these are reviewed. This case is the third patient reported to have the Aase syndrome who also has a cleft lip. Bone marrow cultures failed to stimulate production of erythropoietic precursors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00441882
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Iron therapy resistant microcytic anaemia in a 13-year-old girl with Castleman disease (1996)
    Springer
    European journal of pediatrics 155 (1996), S. 1015-1017 
    Details
    ISSN: 1432-1076
    Keywords: Key words Castleman disease ; Microcytic anaemia ; Childhood
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We describe the case history of a 13-year-old girl with chronic fatigue and prolonged microcytic anaemia. She received oral iron since the age of 11 but failed to respond to it. Laboratory studies revealed elevated C-reactive protein and hypergammaglobulinaemia. A large solitary mesenterial lymph node could be demonstrated by ultrasonography and CT. A diagnosis of Castleman disease was suspected and confirmed histologically. After surgical removal of the lymphoma the patient recovered completely. Conclusion Castleman disease should be considered in cases of chronic fatigue, unexplained fever, microcytic anaemia and hypergammaglobulinaemia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004310050524
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    Paper (German National Licenses)
    Fulltext
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