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  • 1
    Electronic Resource
    Electronic Resource
    Theophylline inhibits platelet aggregation, prostaglandin and thromboxane production by a mechanism which is independent of cyclic AMP (1984)
    Springer
    Inflammation research 14 (1984), S. 102-108 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Theophylline (0.05–1.0 mM) greatly enhanced the inhibition of platelet aggregation by prostaglandin E1 and at higher concentrations (1.0–4.0 mM) theophylline alone inhibited platelet aggregation, by a mechanism which did not involve significant changes in platelet cAMP levels. These concentrations of theophylline and theophylline in combination with prostaglandin E1, inhibited the synthesis of thromboxane A2, prostaglandin E2 and F2α in stimulated platelets. Theophylline also inhibited arachidonic acid-stimulated platelet aggregation suggesting an effect on cyclooxygenase activity. The calcium ionophore A23187 prevented and reversed the inhibition of platelet aggregation by theophylline, suggesting that theophylline inhibits the rise in intracellular calcium levels which occurs in response to the synthesis of prostaglandin endoperoxides and thromboxane A2.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01966841
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Long-chain 3-hydroxyacyl-coenzyme A dehydrogenase deficiency—diagnosis, plasma carnitine fractions and management in a further patient (1993)
    Springer
    European journal of pediatrics 152 (1993), S. 433-436 
    Details
    ISSN: 1432-1076
    Keywords: Long-chain 3-hydroxyacyl-coenzyme A dehydrogenase ; Long-chain acyl carnitine ; Dietary management
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Long-chain 3-hydroxyacyl-coenzyme A dehydrogenase (LCHAD), the third enzyme of the mitochondrial β-oxidation pathway, carries out the dehydrogenation of 3-hydroxyacyl-CoA compounds of 12–18 carbon length. To date only nine cases of LCHAD deficiency have been documented. We report a further patient who as a neonate developed non-specific gastro-intestinal symptoms and at 5 months of age cardiomyopathy, recurrent hypoketotic hypoglycaemia and gross alterations of plasma carnitine fractions. Dietary management with medium chain triglycerides led rapidly to clinical improvement. There was a close correlation between the clinical condition, plasma carnitine fractions and cardiac function. At 2 years of age she is developing normally.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01955905
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Comparison between a standard pancreatic supplement and a high enzyme preparation in cystic fibrosis (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Alimentary pharmacology & therapeutics 6 (1992), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: This study compared the relative effectiveness of a standard pancreatic enzyme supplement (‘Creon’, Duphar) and a new preparation (‘Pancrease HL’, Cilag) containing about 3 times the lipase and more than 5 times the protease activity. Capsule dosage was adjusted to a ratio of approximately 3:1. Fat balances showed that absorption of fat did not change significantly on conversion to the new high-lipase product, and the coefficient of absorption of total energy was similarly maintained. The coefficient of protein absorption was significantly enhanced with the high enzyme preparation (P 〈 0.01), which may explain the reported subjective improvement in stool odour. No adverse effects were recorded. Patient acceptability of the new compound was high; the great reduction in the number of capsules required at each meal was cited by all patients as the reason for their preference.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.1992.tb00569.x
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  • 4
    Electronic Resource
    Electronic Resource
    Comparison of three regimens in the management of acute gastroenteritis in infants (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Alimentary pharmacology & therapeutics 4 (1990), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Sixty infants were randomly assigned to one of three groups on admission to hospital with a diagnosis of gastroenteritis. After rehydration, Group A received a low-lactose, low-fat feed (HN25) in full strength; Group B were regraded on to a conventional formula (SMA); Group C received a hydrolysed soya and collagen feed (Prejomin) in full strength. All feeds were continued for 5 days. The median duration of loose stools from starting the feed was 24 hours in Group A, compared to 119 hours and 95 hours in Groups B and C, respectively. Group A showed a mean percentage increase in weight of 2.34%, Group B showed a mean loss of 1.45%, and Group C a mean increase of 0.15%. These differences were statistically significant. Recovery from gastroenteritis is hastened by the use of a low-lactose, low-fat feed in the initial post-rehydration phase of the disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.1990.tb00492.x
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    CUTIS GYRATUM, ACANTHOSIS NIGRICANS AND OTHER CONGENITAL ANOMALIES A NEW SYNDROME (1969)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 81 (1969), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: SUMMARY. A boy with a complex combination of physical features is reported. These include an unusual fades with hypertelorism, cutis gyratum, acanthosis nigricans, abnormal genitalia, cleft of the soft palate, bifid uvula, premature eruption of teeth, partial anodontia, retardation of bone growth and functional pyloric obstruction. These features are compared with those of leprechaunism, Seip's syndrome, and a case of “leprechaunism” in a male described by Patterson and Watkins (1962). The aetiology is unknown.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1969.tb13975.x
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Production of Duodenal Ulcers and Hypertrophic Pyloric Stenosis by Administration of Pentagastrin to Pregnant and Newborn Dogs (1970)
    [s.l.] : Nature Publishing Group
    Nature 225 (1970), S. 284-285 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In the first experiment 2 mg of depot pentagastrin was given twice daily for the last 20 days of gestation to a crossbred bitch (whippet x greyhound) which had been mated with a greyhound. The eight offspring were divided into two sets, one set receiving further injections of pentagastrin (1 mg ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/225284a0
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  • 7
    Electronic Resource
    Electronic Resource
    The influence of nutrition on neonatal respiratory muscle function (1992)
    Springer
    Intensive care medicine 18 (1992), S. 105-108 
    Details
    ISSN: 1432-1238
    Keywords: Very low birthweight infant ; Nutrition ; Respiratory muscles ; Mechanical ventilation ; Bronchopulmonary dysplasia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Advances in neonatal intensive care have resulted in increasing survival of very small babies, who often require prolonged periods of mechanical ventilation. These babies have limited nutritional reserves, and are difficult to feed by either parenteral or enteral routes. This review article discusses the interaction between undernutrition and respiratory muscle function in the critically ill preterm baby.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01705042
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