Publication Date:
2020-08-05
Description:
An algorithm based on a delayed constraint generation method for solving semi-infinite programs
for constructing minimax optimal designs for nonlinear models is proposed. The outer optimization level of the minimax
optimization problem is solved using a semidefinite programming based approach that requires
the design space be discretized. A nonlinear programming solver is then used to solve the inner program
to determine the combination of the parameters that yields the worst-case value of the design criterion.
The proposed algorithm is applied to find minimax optimal designs for the logistic model, the flexible 4-parameter
Hill homoscedastic model and the general nth order consecutive reaction model, and shows that it
(i) produces designs that compare well with minimax $D-$optimal designs obtained from semi-infinite programming method in the literature;
(ii) can be applied to semidefinite representable optimality criteria, that include the common A-, E-,G-, I- and D-optimality criteria;
(iii) can tackle design problems with arbitrary linear constraints on the weights; and
(iv) is fast and relatively easy to use.
Language:
English
Type:
reportzib
,
doc-type:preprint
Format:
application/pdf
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