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  • 1
    Electronic Resource
    Electronic Resource
    Muscarinic inhibition of potassium-induced noradrenaline release and its dependence on the calcium concentration (1975)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 291 (1975), S. 1-15 
    Details
    ISSN: 1432-1912
    Keywords: Heart ; Noradrenaline release ; Potassium ; Calcium ; Methacholine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. Noradrenaline release from the isolated rabbit heart was evoked by perfusion with a medium containing 135 mM potassium and 17 mM sodium ions (high K+-low Na+). 2. The noradrenaline output in response to high K+-low Na+ was dose-dependently decreased by methacholine (0.625–320 μM) and this effect was reserved by atropine 1.44 μM. 3. Lowering the calcium concentration of high K+-low Na+ from 1.8–0.1125 mM decreased the noradrenaline output by 85%. The effect of methacholine, expressed as % inhibition of noradrenaline release, was potentiated by lowering of the calcium concentration. 4. Both at normal and lowered calcium concentrations the inhibitory action of methacholine was larger from 0–5 than from 5–10 min after perfusion with high K+-low Na+. 5. Perfusion of hearts with media containing high K+-high Na+ or normal K+-low Na+ caused noradrenaline outputs somewhat smaller than those after high K+-low Na+. The release from 0–5 min was both calcium-dependent and inhibited by methacholine. 6. High K+ and/or low Na+ solutions caused an increase in coronary perfusion pressure which was little affected by the noradrenaline released simultaneously. 7. It is concluded that activation of muscarine receptors at the terminal adrenergic fibre decreases the availability of calcium for transmitter release.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00510816
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Manganese-induced biochemical changes in growing versus adult rats (1980)
    Springer
    Archives of environmental contamination and toxicology 9 (1980), S. 383-391 
    Details
    ISSN: 1432-0703
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Abstract Manganese chloride was administered daily intraperitoneally to growing and adult rats for a period of 30 days to compare certain biochemical parameters in both groups of animals. Marked alterations in the levels of dopamine and norepinephrine in the brain was observed in manganese-treated growing rats. Furthermore, the contents of tyrosine, tryptophan in blood, liver, and brain have been significantly altered in these animals. Identical manganese administration to adult rats had no effect on the contents of tyrosine in liver and brain, nor tryptophan, and dopamine in the brain. Some of the parameters which were altered in the adult rats were less in magnitude compared to the growing animals. The experiments indicated higher susceptibility of the growing rats to the toxic effects of this metal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01055290
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    Paper (German National Licenses)
    Fulltext
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