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  • 1
    Electronic Resource
    Electronic Resource
    Localization of Transforming Growth Factors, TGFβ1 and TGFβ3, in Hypothalamic Magnocellular Neurones and the Neurohypophysis (2004)
    Oxford, UK : Blackwell Science Ltd
    Journal of neuroendocrinology 16 (2004), S. 0 
    Details
    ISSN: 1365-2826
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The distribution of transforming growth factor beta (TGFβ) in the rat and human hypothalamus and neurohypophysis was investigated by immunocytochemical techniques using rabbit polyclonal antisera against TGFβ1 and TGFβ3. Colocalization of TGFβ1 or TGFβ3 and arginine vasopressin (AVP) in the rat hypothalamus was studied by double immunolabelling in light microscopy, while their subcellular localization in the rat neurohypophysis was investigated by immunoelectron microscopy. TGFβ1 and TGFβ3 immunoreactivity was demonstrated in the cell bodies and processes of neurones in the supraoptic nucleus (SON) and paraventricular nucleus (PVN). The TGFβ-immunoreactive cells were more numerous in the SON compared to the PVN. TGFβ/AVP double-labelled cells were seen in both nuclei, but some neurones in the SON were labelled for TGFβ1 or TGFβ3, although not for AVP. In the rat and human neurohypophysis, TGFβ3 immunolabelling was more diffuse and stronger than TGFβ1 immunolabelling. TGFβ1 expression was seen in axonal vesicles and in neurosecretory granules of the axonal endings, while TGFβ3 was observed in axonal fibres. Colocalization of TGFβ3 or TGFβ1 and AVP was observed in some neurosecretory granules, but many were either single-labelled for TGFβ or AVP or unlabelled. Our results demonstrate, for the first time, the colocalization of TGFβ and neurohypophysial hormones in magnocellular neurones. We suggest that TGFβ secreted by the neurohypophysis regulates the proliferation and secretion of certain anterior pituitary cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2826.2004.01203.x
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  • 2
    Electronic Resource
    Electronic Resource
    Farber disease: an ultrastructural study (1992)
    Springer
    Virchows Archiv 420 (1992), S. 281-290 
    Details
    ISSN: 1432-2307
    Keywords: Farber disease ; Ultrastructural pathology ; Ceramides ; Skin biopsy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A case of Farber disease is reported and the ultrastructural pathology of the disease is reviewed. The present case showed the typical clinical picture of Farber disease. Acid ceramidase deficiency was demonstrated biochemically. Ultrastructural features of one subcutaneous nodule and a skin biopsy are described. Three lysosomal inclusions characterize Farber disease: curvilinear tubular bodies observed mainly in the reticuloendothelial system, “banana bodies” recorded only in the peripheral nervous system and zebra-like bodies which are essentially a neuronal storage. The nature of each is discussed and the skin biopsy is emphasized for its important diagnostic interest.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01600282
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Fetal Niemann-Pick disease type C: Ultrastructural and lipid findings in liver and spleen (1993)
    Springer
    Virchows Archiv 422 (1993), S. 253-259 
    Details
    ISSN: 1432-2307
    Keywords: Niemann-Pick disease type C ; Fetal liver ; Fetal spleen ; Ultrastructural pathology ; Cholesterol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We present the first ultrastructural study of liver and spleen from a 20-week fetus with Niemann-Pick disease type C in correlation with lipid studies of these tissues. The lipid storage pattern was characteristic of the disease and although the distribution of the lipid storage was similar to that of affected children, ultrastructural studies emphasized that many inclusions were qualitatively different. These are discussed. Concomitant with this complex lipid storage, ultrastructural evidence of cholestasis was observed and the early hyperplasia of pericanalicular microfilaments leads us to question the presence of a toxic metabolite which might induce cholestasis by acting upon microfilaments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01621810
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  • 4
    Electronic Resource
    Electronic Resource
    In vitro Toxic Effects of Certain Antibiotics on the Fibroblasts of Two Children with I-Cell Disease (1998)
    Springer
    Cell biology and toxicology 14 (1998), S. 333-343 
    Details
    ISSN: 1573-6822
    Keywords: antibiotics ; cultured fibroblasts ; cytotoxicity ; I-cell disease ; ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Six antibiotics, pefloxacin (Peflacine), fosfomycin (Fosfocine), teicoplanin (Targocid), vancomycin (Vancocine), ceftazidime (Fortum), piperacillin (Piperilline), that may be used as a systematic coverage during bone marrow transplantation have been tested on dermal fibroblasts of one control subject and two I-cell disease patients, along with five subcultures, corresponding to 5 weeks of culture. The possible toxicity of these molecules was assessed. The evaluation of lysosomal enzyme sphingomyelinase activity, detection of free intracellular cholesterol and the light- and electron-microscopic examination of treated cells were used as measures of metabolic interference and cytotoxicity. Our study shows that despite a lack of any metabolic sign of interference (no modification in enzyme activity, no increase in free intracellular cholesterol), all the antibiotics tested induced a cytotoxic effect which was notably amplified in the I-cell populations. This may be due to the lysosomal lipid storage of these cells which modifies the relationship between the antibiotic and the cell by inducing a different kind of lipid–antibiotic interference.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1007533723782
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    Paper (German National Licenses)
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