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  • 1
    Electronic Resource
    Electronic Resource
    Enlarged adenomectomy for enclosed prolactinomas: A preliminary study of 26 cases (1990)
    Springer
    Acta neurochirurgica 103 (1990), S. 92-98 
    Details
    ISSN: 0942-0940
    Keywords: Pituitary adenoma ; microprolactinoma ; enclosed prolactinomas ; transsphenoidal microsurgery ; hyperprolactinaemia ; enlarged adenomectomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Preliminary results obtained from 26 cases of prolactinomas less than 20 mm in diameter after treatment by enlarged adenomectomy are described. The operation consisted in removal of the adenoma, a layer of normal pituitary at the outer edge of the tumour and the pituitary capsule in contact with the sellar meninges. 24 women and 2 men were involved whose prolactin levels (PRL) were less than 200 ng/ ml. All presented abnormal PRL responses to Thyrotropin releasing hormone (TRH) and Metoclopramide (MCP) tests and an absence of a nocturnal rise in the sleep cycle study. Postoperatively, three patients developed transitory diabetes insipidus and five transitory adrenal insufficiency. Gonadotropin reserve was always found normal. All 24 women resumed normal menstrual cycles and two became pregnant within one year. From a serological viewpoint, after surgery 100% of patients were found to be normal for levels of prolactin but only 85% turned to normal dynamic tests. The results of this small series of enlarged adenomectomies seem better than those obtained using selective adenomectomy, but must be confirmed with time.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01407512
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  • 2
    Electronic Resource
    Electronic Resource
    Localization of Transforming Growth Factors, TGFβ1 and TGFβ3, in Hypothalamic Magnocellular Neurones and the Neurohypophysis (2004)
    Oxford, UK : Blackwell Science Ltd
    Journal of neuroendocrinology 16 (2004), S. 0 
    Details
    ISSN: 1365-2826
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The distribution of transforming growth factor beta (TGFβ) in the rat and human hypothalamus and neurohypophysis was investigated by immunocytochemical techniques using rabbit polyclonal antisera against TGFβ1 and TGFβ3. Colocalization of TGFβ1 or TGFβ3 and arginine vasopressin (AVP) in the rat hypothalamus was studied by double immunolabelling in light microscopy, while their subcellular localization in the rat neurohypophysis was investigated by immunoelectron microscopy. TGFβ1 and TGFβ3 immunoreactivity was demonstrated in the cell bodies and processes of neurones in the supraoptic nucleus (SON) and paraventricular nucleus (PVN). The TGFβ-immunoreactive cells were more numerous in the SON compared to the PVN. TGFβ/AVP double-labelled cells were seen in both nuclei, but some neurones in the SON were labelled for TGFβ1 or TGFβ3, although not for AVP. In the rat and human neurohypophysis, TGFβ3 immunolabelling was more diffuse and stronger than TGFβ1 immunolabelling. TGFβ1 expression was seen in axonal vesicles and in neurosecretory granules of the axonal endings, while TGFβ3 was observed in axonal fibres. Colocalization of TGFβ3 or TGFβ1 and AVP was observed in some neurosecretory granules, but many were either single-labelled for TGFβ or AVP or unlabelled. Our results demonstrate, for the first time, the colocalization of TGFβ and neurohypophysial hormones in magnocellular neurones. We suggest that TGFβ secreted by the neurohypophysis regulates the proliferation and secretion of certain anterior pituitary cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2826.2004.01203.x
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  • 3
    Electronic Resource
    Electronic Resource
    Clinical studies with human growth hormone releasing factor in normal adults and patients
    Amsterdam : Elsevier
    Peptides 7 (1986), S. 281-286 
    Details
    ISSN: 0196-9781
    Keywords: Growth hormone (GH) ; Human growth hormone releasing factor (hGRF) ; Human studies, males
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0196-9781(86)90203-2
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  • 4
    Electronic Resource
    Electronic Resource
    Renin immunoreactivity in the human, normal and tumoral anterior pituitary
    Amsterdam : Elsevier
    Regulatory Peptides 53 (1994), S. 155 
    Details
    ISSN: 0167-0115
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0167-0115(94)90650-5
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  • 5
    Electronic Resource
    Electronic Resource
    Features of new cell lines established from the transplantable MCTF tumor whose growth is inhibited by estradiol(E)
    Amsterdam : Elsevier
    Journal of Steroid Biochemistry 25 (1986), S. 121 
    Details
    ISSN: 0022-4731
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0022-4731(86)90778-8
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  • 6
    Electronic Resource
    Electronic Resource
    Inhibition of the MtTF"4 tumor growth by dexamethasone
    Amsterdam : Elsevier
    Journal of Steroid Biochemistry 30 (1988), S. 369-373 
    Details
    ISSN: 0022-4731
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0022-4731(88)90125-2
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  • 7
    Electronic Resource
    Electronic Resource
    159 Dual effects of estradiol on the transplantable MtTF"4 pituitary tumor
    Amsterdam : Elsevier
    Journal of Steroid Biochemistry 19 (1983), S. 53 
    Details
    ISSN: 0022-4731
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0022-4731(83)91659-X
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  • 8
    Electronic Resource
    Electronic Resource
    Morphological and biochemical relationships in 31 human pituitary adenomas with acromegaly (1980)
    Springer
    Virchows Archiv 389 (1980), S. 127-142 
    Details
    ISSN: 1432-2307
    Keywords: Human pituitary adenoma ; Acromegaly ; Light and electron microscopy ; Immunofluorescence ; Radioimmunoassay of GH
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In 22 pure GH cell adenomas and 9 mixed GH cell-prolactin cell adenomas with acromegaly, we compare the morphological and functional data (secretory activity and granular appearance) with GH levels (radioimmunoassays) in the blood and in the tumor. According to morphological criteria, the secretory activity is marked in 13 cases (Group I), mild in 9 cases (Group II), and weak in 9 others (Group III). The mean values of the plasma GH levels in the 3 groups (80 ng/ml±22; 26.5 ng/ml±2; and 16.89 ng/ml±2 respectively) are significantly different. In 17 densely granulated adenomas and 14 sparsely granulated adenomas, the plasma GH values were very variable. The mean levels of these 2 groups (49.76 ng/ml±22 and 41.8 ng/ml±7.8 respectively) are not significantly different. The GH concentrations in the tumor were also very variable (358 to 78,900 ng/mg). Their highly significant relationship with the granular appearance is an indirect proof of the granular localisation of GH. We distinguish between 4 functional aspects of the GH cell adenoma which define the different levels of synthesis, storage, and excretion. The secretory activity of the GH adenomatous cell varies with the adenomas and differs from that of the normal cell.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00439481
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  • 9
    Electronic Resource
    Electronic Resource
    Angulate lysosomes in skin biopsies of patients with degenerative neurological disorders: high frequency in neuronal ceroid lipofuscinosis (1999)
    Springer
    Acta neuropathologica 98 (1999), S. 91-96 
    Details
    ISSN: 1432-0533
    Keywords: Key words Angulate lysosomes ; Trilamellar structures ; Skin biopsy ; Neurodegenerative disorders ; Neuronal ; ceroid lipofuscinosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Angulate lysosomes with intralysosomal trilamellar structures were first described in patients with metabolic peroxisomal disorders. In this ultrastructural study of skin biopsies of 139 patients with degenerative neurological disorders and 45 patients with static encephalopathies, we observed angulate lysosomes with similar ultrastructure exclusively in degenerative neurological disorders. They were found in only a few cases (8%), but especially in patients with degenerative metabolic disorders (72%). Because they were never observed in patients with static encephalopathies, angulate lysosomes in the skin would seem to be a sign of progressive encephalopathy. The great majority (75%) of angulate lysosomes were associated with neuronal ceroid-lipofuscinosis (NCL). Their presence in skin biopsy could suggest the diagnosis of NCL and eliminate a peroxisomal disorder. In the latter pathology, angulate lysosomes, numerous in the liver and in the brain, were never observed in the skin. As described in pigmentary retinopathy, a conspicuous feature of NCL, we suggest that in this lysosomal storage disorder, the angulate lysosomes in skin biopsies could result from the phagocytosis of melanin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004010051055
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  • 10
    Electronic Resource
    Electronic Resource
    Immunocytochemical study of Wulzen's cone of the bovine pituitary (1982)
    Springer
    Cell & tissue research 227 (1982), S. 55-65 
    Details
    ISSN: 1432-0878
    Keywords: Wulzen's cone ; Immunofluorescence ; Bovine adenohypophysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Résumé Le cône de Wulzen de l'adénohypophyse bovine présente un développement et une disposition générale variables. Il est accolé à la pars intermedia dont il n'est séparé par aucune cloison conjonctive. Du côté de la fente hypophysaire, il est revêtu par un épithélium simple, cubique. En immunofluorescence, on observe la présence de divers types de cellules glandulaires: les plus abondantes sont des cellules mises en évidence par un anticorps anti-oPRL, isolées ou groupées en amas. D'autres cellules réagissent avec des anticorps anti-hGH, et anti-bLH, anti-βoLH ou anti-/mTSH. Quelques cellules réagissent simultanément avec des anticorps anti-βMSH, anti-1–24ACTH, anti-17–39ACTH, anti-βLPH et anti-βendorphine. Mises à part les nombreuses cellules à prolactine, les autres types cellulaires apparaissent constamment sous l'aspect d'éléments isolés. Nous n'avons pas observé de cellules réagissant avec des anticorps anti-leu-enképhaline, antiinet-enképhaline ou anti-calcitonine ni dans le cône de Wulzen, ni dans la pars distalis et dans la pars intermedia.
    Notes: Summary The Wulzen's cone of the bovine adenohypophysis presents a variable development and general arrangement. It is joined to the pars intermedia with no intervening connective tissue. It is covered by a single layer of cubical cell epithelium on the side of the hypophysial cleft. Immunofluorescence reveals the presence of different glandular cell types. The most abundant cells are those demonstrated by an anti-oPRL antibody and are either isolated or clustered. Other cells react with anti-hGH, anti-bLH, anti-βoLH or anti-βhTSH antibodies. Some cells react simultaneously with anti-βMSH, anti-1–24ACTH, anti-17–39ACTH, anti-βLPH and anti-βendorphin antibodies. Cell types other than the numerous prolactin cells appear only as isolated elements. We did not observe cells reacting with anti-leu-enkephalin, anti-met-enkephalin or anti-calcitonin antibodies either in the Wulzen's cone or in the pars distalis or pars intermedia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00206331
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