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  • 1
    Electronic Resource
    Electronic Resource
    Predictive power of cytomorphological features in equivocal (C3, C4) breast FNAC (2004)
    Oxford, UK : Blackwell Science Ltd
    Cytopathology 15 (2004), S. 0 
    Details
    ISSN: 1365-2303
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Definitive immediate diagnosis in breast fine needle aspiration cytology (FNAC) remains the aim for cytopathologists. We reviewed 72 consecutive equivocal (C3 and C4) aspirates with respect to 16 cytomorphological criteria. We assessed the power of each criterion at predicting either a malignant [positive predictive value (PPV)] or a benign [negative predictive value (NPV)] diagnosis by correlation with follow-up histology. Blind review led to 34% of cases being correctly definitively diagnosed. Eccentrically placed epithelial cell nuclei (PPV = 88%, sensitivity = 67%, specificity = 87%) and coarse nuclear chromatin (PPV = 81%, sensitivity = 72%, specificity = 83%) are the features that are most useful in predicting malignancy in this selected series. The presence of myoepithelial cells within epithelial groups is not a good indicator of a benign diagnosis (NPV = 24%, sensitivity = 80%, specificity = 53%).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2303.2004.00157.x
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  • 2
    Electronic Resource
    Electronic Resource
    Scoring nuclear pleomorphism in breast cancer (2001)
    Oxford UK : Blackwell Science Ltd
    Histopathology 39 (2001), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Scoring nuclear pleomorphism in breast cancer Aims: Nuclear grade has equal weight with mitotic index and acinus formation in grading breast cancer, but criteria for its assessment are less well defined. This study examines consistency of nuclear grading in breast cancer and whether improved nuclear grading criteria are required. Methods and results: Photographic prints of haematoxylin–eosin sections of 100 unselected symptomatic breast cancers were circulated to histopathologists who assigned each carcinoma a nuclear pleomorphism score on a linear analogue scale 0–100 (0–33 equating to nuclear pleomorphism grade 1, 34–66 to grade 2, and 67–100 to grade 3). Seventeen histopathologists completed the exercise, including 11 breast specialists. While κ scores for the implied nuclear grades indicated ‘moderate’ or ‘good’ agreement between individuals and the group as a whole, seven pathologists allocated analogue scores significantly lower than the median score allocated by the group to each case, while five allocated significantly higher scores. The range was from analogue scores 11.3 units lower on average than the median (assigning 27% of carcinomas nuclear grade 1, 60% grade 2, and 13% grade 3) to scores 7.5 units higher on average than the median (assigning only 2% carcinomas nuclear grade 1, 46% grade 2, and 52% grade 3). Five of six non-specialists allocated scores significantly lower than the group medians but only two of 11 specialists did so (P=0.018). Conclusions: Systematic differences between pathologists in scoring nuclear pleomorphism in breast cancer potentially contribute to differences in allocating overall grade and confirm the need for improved nuclear grading criteria. Specialists tend to allocate higher pleomorphism scores than non-specialists.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2559.2001.01220.x
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  • 3
    Electronic Resource
    Electronic Resource
    Triphenylphosphine: a redetermination (1991)
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 47 (1991), S. 345-347 
    Details
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S010827019000508X
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Materials and devices toward three-dimensional integration
    Amsterdam : Elsevier
    Microelectronic Engineering 8 (1988), S. 235-253 
    Details
    ISSN: 0167-9317
    Keywords: LDMOS ; Recrystallization ZMR ; electron beam ; laser ; smart-power ; three-dimensional integration
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Electrical Engineering, Measurement and Control Technology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0167-9317(88)90019-6
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    Paper (German National Licenses)
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