ISSN:
1432-1440
Keywords:
Diabetes mellitus type I
;
Lipid parameters
;
Intensified insulin treatment
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Premature atherosclerosis is often found in patients with diabetes mellitus (DM) type I, and alterations in lipid metabolism seem to play an important role in the development of this complication. Intensified insulin therapy improves glycemic control parameters significantly. To evaluate the effect of this optimized insulin treatment (OIT) not only on glycemic control, but also on plasma lipids, 24 patients with DM type I (19 men and 5 women, 18 to 61 years) were switched from a standard insulin therapy to a regimen of OIT which has been maintained for more than 3 years now. After 2 years on OIT a reduction of HbAlc values from 8.1% to 7.5% (p〈0.0l) was accompanied by an increase in HDL cholesterol from 52 to 67 mg/dl (p〈0.05) and a decrease of triglyceride levels from 319 to 67 mg/dl (p〈0.001). At the end of the second year on OIT some of the patients exhibited a reversal of the favorable trend in HbAlc and lipid values. Intensified instructions regarding the implementation of OIT were therefore repeated and resulted in a renewed improvement of overall HbAlc, HDL cholesterol and triglyceride levels to 6.43%, 67 mg/dl, and 78 mg/dl, respectively. Our findings underline the value of OIT not only for glycemic control, but also for the control of plasma lipids considered to be major risk factors for coronary artery disease.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01649419
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