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  • 1
    Electronic Resource
    Electronic Resource
    Nutritional evaluation of RAZ-2, a new Phaseolus vulgaris bean cultivar containing high levels of the natural insecticidal protein arcelin 1 (1993)
    s.l. : American Chemical Society
    Journal of agricultural and food chemistry 41 (1993), S. 436-440 
    Details
    ISSN: 1520-5118
    Source: ACS Legacy Archives
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jf00027a017
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  • 2
    Electronic Resource
    Electronic Resource
    Betel nut (Areca catechu) consumption and the induction of glucose intolerance in adult CD1 mice and in their F1 and F2 offspring (1994)
    Springer
    Diabetologia 37 (1994), S. 49-55 
    Details
    ISSN: 1432-0428
    Keywords: Key words Diabetes mellitus, nitrosamines, nitroso-compounds, Areca catechu, Betel nut, inheritance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Many mutagenic nitroso compounds are also diabetogenic. Betel-nut (Areca catechu) chewing populations have an increased incidence of foregut cancers related to betel-nut nitrosamines which suggests that betel consumption could be diabetogenic. Young adult CD1 mice with a low spontaneous incidence of diabetes were fed betel nut in standard feed for 2–6 days. Single point (90 min) intra-peritoneal glucose tolerance tests were used to follow glucose tolerance up to 6 months of age. Glucose intolerance was defined as over 3 SD above mean control values. Glucose intolerance was found in 3 of 51 male and 4 of 33 female adult mice which were fed the betel diet (p 〈0.01). Studies on the progeny of these mice are presented separately for animals studied in Aberdeen (Group 1) and London (Group 2). In matings of Group 1 betel-fed parents glucose intolerance was found in 4 of 25 male and 1 of 22 female F1 offspring, with significant hyperglycaemia in F1 males born to hyperglycaemic but not to normoglycaemic mothers (p 〈0.01). In the F2 generation 4 of 23 males and 1 of 16 females and in the F3 generation 1 of 16 males and 0 of 20 females were glucose intolerant. In the Group 2 studies where betel-fed parents were mated to normal controls glucose intolerance was found in 10 of 35 male and 10 of 33 female F1 progeny (p 〈0.005), and mean islet areas were increased in offspring of betel-fed parents (p 〈0.001). The total incidence of glucose intolerance in F1 progeny from studies in Groups 1 and 2 was 14 of 60 males and 11 of 55 females (p 〈0.005). Insulin dependence did not develop in the glucose-intolerant betel-fed animals or their descendants; affected animals appearing well built and active. The development of glucose intolerance in F1 offspring was not dependent on maternal glucose intolerance or on maternal betel-feeding, and 90-min glucose levels of F1 offspring were directly related to paternal but not to maternal glycaemia (p 〈0.01). Our findings suggest that betel-nut (Areca) consumption may be diabetogenic and induce an inheritable abnormality. The hypothesis is of interest in view of the widespread habit of betel consumption and of the strategies known to inhibit the induction of experimental diabetes by diabetogenic nitroso compounds. [Diabetologia (1994) 37: 49–55]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00428777
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  • 3
    Electronic Resource
    Electronic Resource
    Betel nut (Areca catechu) consumption and the induction of glucose intolerance in adult CD1 mice and in their F1 and F2 offspring (1994)
    Springer
    Diabetologia 37 (1994), S. 49-55 
    Details
    ISSN: 1432-0428
    Keywords: Diabetes mellitus ; nitrosamines ; nitrosocompounds ; Areca catechu ; Betel nut ; inheritance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Many mutagenic nitroso compounds are also diabetogenic. Betel-nut (Areca catechu) chewing populations have an increased incidence of foregut cancers related to betel-nut nitrosamines which suggests that betel consumption could be diabetogenic. Young adult CD1 mice with a low spontaneous incidence of diabetes were fed betel nut in standard feed for 2–6 days. Single point (90 min) intra-peritoneal glucose tolerance tests were used to follow glucose tolerance up to 6 months of age. Glucose intolerance was defined as over 3 SD above mean control values. Glucose intolerance was found in 3 of 51 male and 4 of 33 female adult mice which were fed the betel diet (p〈0.01). Studies on the progeny of these mice are presented separately for animals studied in Aberdeen (Group 1) and London (Group 2). In matings of Group 1 betel-fed parents glucose intolerance was found in 4 of 25 male and 1 of 22 female F1 offspring, with significant hyperglycaemia in F1 males born to hyperglycaemic but not to normoglycaemic mothers (p〈0.01). In the F2 generation 4 of 23 males and 1 of 16 females and in the F3 generation 1 of 16 males and 0 of 20 females were glucose intolerant. In the Group 2 studies where betel-fed parents were mated to normal controls glucose intolerance was found in 10 of 35 male and 10 of 33 female Fl progeny (p〈0.005), and mean islet areas were increased in offspring of betel-fed parents (p〈0.001). The total incidence of glucose intolerance in Fl progeny from studies in Groups 1 and 2 was 14 of 60 males and 11 of 55 females (p〈0.005). Insulin dependence did not develop in the glucose-intolerant betel-fed animals or their descendants; affected animals appearing well built and active. The development of glucose intolerance in F1 offspring was not dependent on maternal glucose intolerance or on maternal betel-feeding, and 90-min glucose levels of F1 offspring were directly related to paternal but not to maternal glycaemia (p〈0.01). Our findings suggest that betelnut (Areca) consumption may be diabetogenic and induce an inheritable abnormality. The hypothesis is of interest in view of the widespread habit of betel consumption and of the strategies known to inhibit the induction of experimental diabetes by diabetogenic nitroso compounds.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00428777
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  • 4
    Electronic Resource
    Electronic Resource
    Follicular psoriasis (1981)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 104 (1981), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: This is a report on ten patients with follicular psoriasis. Two distinct clinical types could be distinguished. An adult form, seen especially in women, presented with widespread psoriasis in which follicular lesions occurred on both thighs as part of the efflorescence. Follicular lesions were aggregated to form isolated asymmetrical plaques on the trunks of children with inactive psoriasis.The histological findings in follicular psoriasis varied according to the age of the lesion. In the early lesion there was a marked dermal infiltrate in which the mast cells were prominent but the hair follicle appeared normal. Older lesions were found to have nucleated cells in the ostium of the follicle. These findings suggest that the hair follicle may be affected as part of psoriatic involvement of the integument.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1981.tb00037.x
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  • 5
    Electronic Resource
    Electronic Resource
    CHLOROQUINE-INDUCED MYOPATHY (1969)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 81 (1969), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: SUMMARY.— A case of generalized muscle weakness due to prolonged chloroquine ingestion is described. The clinical and histological findings are discussed. Eventual recovery of function can be expected.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1969.tb16011.x
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  • 6
    Electronic Resource
    Electronic Resource
    CROHN'S DISEASE OF THE MOUTH (1972)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 87 (1972), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A patient with histologically proven Crohn's disease of the ileum and caecum presented with unusual ulceration of the mouth 3 years after subtotal colectomy. Worsening of bowel symptoms was associated with exacerbation of oral ulceration on several occasions. The areas of ulceration in the mouth were in relation to a sarcoid reaction typical of Crohn's disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1972.tb01599.x
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  • 7
    Electronic Resource
    Electronic Resource
    Cytochrome P-450 localization in normal human adult and foetal liver by immunocytochemistry using a monoclonal antibody against human cytochrome P—450 (1987)
    Springer
    Journal of molecular histology 19 (1987), S. 537-545 
    Details
    ISSN: 1573-6865
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Immunocytochemical studies with a monoclonal antibody (MAb—HL3), which recognises a major isozyme of human hepatic cytochrome P—450, have demonstrated this cytochrome in both cryostat and formalin-fixed paraffin-embedded sections of normal human adult liver. Prior trypsin digestion of the formalin-fixed sections prevented staining. There was a zonal distribution of immunoreactive cytochrome P—450, with localization predominantly in the hepatocytes of zone 3 of the hepatic acinus (the centrilobular region). Cytochrome P—450 was also demonstrated in foetal liver, but all foetal hepatocytes contained immunoreactive cytochrome P—450 and there was no zonal distribution of the protein. The biliary epithelium of adult liver contained a small amount of immunoreactive cytochrome P—450 whereas there was no immunoreactivity in the epithelium of foetal bile ducts.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01687361
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  • 8
    Electronic Resource
    Electronic Resource
    The histochemical demonstration of catecholamines and tryptamines by acid- and aldehyde-induced fluorescence: microspectrofluorometric characterization of the fluorophores in models (1972)
    Springer
    Journal of molecular histology 4 (1972), S. 59-69 
    Details
    ISSN: 1573-6865
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Synopsis Fluorescence excitation and emission spectra are reported of the fluorophores derived from various catecholamines, tryptamines and related substances treated with vapours of acetaldehyde, glutaraldehyde and acetic acid. In most cases, the excitation maxima were at about 400–410 nm, and emission maxima at about 530 nm (catecholamines) or 560 nm (tryptamines). The microspectrofluorometric differentiation of individual arylethylamines by the relative height of excitation peaks at about 400 and 330 nm after treatment with acetic acid vapour is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01005269
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  • 9
    Electronic Resource
    Electronic Resource
    Uptake ofl-DOPA andl-5-hydroxytryptophan by endocrine-like cells in the rat larynx (1972)
    Springer
    Journal of molecular histology 4 (1972), S. 103-110 
    Details
    ISSN: 1573-6865
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Synopsis In the larynx of the rat, and to a lesser extentin the trachea and main bronchi, there are numerous cells which possess the amine-handling characteristics, but not the enzymatic ones, of the APUD series of endocrine polypeptide cells. The cytochemical properties of their contained granules, which are ultrastructurally atypical in reaching sizes up to 2000 nm on their longest axis, are not those of the APUD series since their protein is predominantly basic and arginine-rich, rather than acidic. A weak formaldehyde-induced autofluorescence is present in the cells, due to a substance with an excitation maximum at 400 nm and an emission maximum at 490 nm. This may be dopamine. The true nature of these ‘endocrine-like’ cells is not apparent. They are regarded, for the present, as being related to cutaneous melanocytes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01004969
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  • 10
    Electronic Resource
    Electronic Resource
    New methods for the histochemical demonstration of catecholamines, tryptamines, histamine and other arylethylamines by acid- and aldehyde-induced fluorescence (1971)
    Springer
    Journal of molecular histology 3 (1971), S. 207-212 
    Details
    ISSN: 1573-6865
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Synopsis The histochemical demonstration of catecholamines, tyramines, tryptamines, and related substances depends upon condensation reactions leading to ring closure, ultimately forming a fluorescentisoquinoline, quinonoid or β-carboline. At present, formaldehyde is widely used for such reactions. In this paper the possibilities of other histochemical reagents are considered, and preliminary results obtained with fixative vapours of some other aldehydes (acetaldehyde, glutaraldehyde) and carboxylic acids (formic and acetic acids) are described.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01002565
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