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  • 1
    Electronic Resource
    Electronic Resource
    Review of 59 patients with hypergonadotrophic amenorrhoea (1984)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 91 (1984), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary. Fifty-nine patients presented with elevated concentrations of gonadotrophins and secondary amenorrhoea before the age of 35 years. Fifty-three underwent laparoscopic examination and primordial follicles were observed in 16. Two others had follicles as they later became pregnant and a third showed biochemical evidence of spontaneous ovulation. There were streak ovaries in 12, two with follicles and three others with chromosomal abnormalities, two being 47XXX and one XO/XX. Two other patients had only one ovary each but no follicles. Chromosomal abnormalities were detected in two further patients one being XO/XX and the other a recombinant. Six patients became pregnant, two of them twice, resulting in four term deliveries and four spontaneous abortions. Three other patients showed biochemical evidence of ovulation; one spontaneously, one after oestrogen therapy and the third after treatment with gonadotrophin releasing hormone analogue.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1984.tb05280.x
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  • 2
    Electronic Resource
    Electronic Resource
    A clinical trial using danazol for the treatment of premenstrual tension (1987)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 94 (1987), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary. Forty women with premenstrual tension received either placebo, 100, 200 or 400 mg danazol daily for 3 months in a pilot study arranged as a double-blind trial. Thirteen patients withdrew by the third month usually because they complained of no improvement. They had significantly higher pretrial symptom scores than those who continued. In patients treated with danazol, symptom scores for breast pain during the second and third months and for irritability, anxiety and lethargy during the third month were significantly (P〈0.05) lower than scores in those given placebo. Most symptoms improved on placebo in the first month but by the third month only three remained improved. In contrast eight symptoms were improved on 200 mg danazol by the third month. By the end of the trial more than 75% of patients who were still taking danazol were essentially free of breast pain, lethargy, anxiety and increased appetite, but results for other common symptoms were no better than with placebo.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1987.tb02248.x
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  • 3
    Electronic Resource
    Electronic Resource
    Hormonal studies in women with premenstrual tension (1985)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 92 (1985), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary. Serum hormone concentrations were determined at intervals during the last 17 days of the menstrual cycle in 35 patients with premenstrual tension (PMT) and 11 control subjects without symptoms. The maximum mean concentration of oestradiol occurred 17 days before menstruation in the patients and 14 days before in the controls. The maximum concentrations of progesterone were similar in the two groups but the mean concentrations rose carlier in the cycle in the patients with PMT. These results suggested that the patients tended to ovulate earlier in the cycle than the controls and on the basis of the ovulatory surge in gonadotrophins two groups could be identified, group A who showed signs of ovulation 14 days or less before menstruation (17 patients, 9 controls) and group B who ovulated more than 14 days before menstruation (18 patients, 2 controls). There were no significant differences between the groups in prolactin, thyroid stimulating hormone or testosterone levels, but cortisol concentrations were uniformly higher in both groups of patients compared with those in the controls. Follicular growth was assessed with ultrasound in 18 patients and 16 control subjects. Mean follicular diameters were significantly lower in the patients than in the control group at the time of ovulation. Oestradiol determinations done at the same time correlated with the diameters and were also significantly lower in the patient group. The results suggest that ovulation tends to occur prematurely in women with PMT.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1985.tb01090.x
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  • 4
    Electronic Resource
    Electronic Resource
    SEX HORMONE LEVELS AND GONADOTROPHIN RELEASE IN PREMATURE OVARIAN FAILURE (1978)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 85 (1978), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Premature ovarian failure was studied in ten women under the age of 30; eight had an ovarian biopsy and five of these showed primordial follicles. Plasma levels of oestradiol and progesterone were similar to the follicular phase of a normal menetrual cycle, but in eight patients cervical smears showed a cornification index of less than one per cent. Levels of both androgens and of sex hormone binding globulin capacity were generally normal. Administration of LH-RH caused a release of FSH which was similar to post menopausal women and higher than normally menstruating women, and a release of LH which was higher than both. Two patients were treated with exogenous gonadotrophins without effect.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1978.tb15844.x
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  • 5
    Electronic Resource
    Electronic Resource
    HYPOTHALMIC-PITUITARY RELATIONSHIPS IN THE POLYCYSTIC OVARY SYNDROME SERUM GONADOTROPHIN LEVELS FOLLOWING INJECTION OF OESTRADIOL BENZOATE (1975)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 82 (1975), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Injection of oestradiol benzoate was found to elicit a surge of luteinizing hormone (LH) in 15 of 19 patients with polycystic ovary (PCO) syndrome; follicle stimulating hormone (FSH) was also released, in conjunction with the LH surge, in eight patients. It is concluded that the oestrogen feedback mechanisms controlling mid-cycle gonadotrophin release are functioning normally in the majority of patients with PCO syndrome. Ovulation was subsequently induced by clomiphene alone in those patients who had an LH surge, and by a combination of clomiphene and human chorionic gonadotrophin (HCG) in those who had not shown any LH release.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1975.tb00604.x
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  • 6
    Electronic Resource
    Electronic Resource
    ENDOCRINE STUDIES IN POST-MENOPAUSAL WOMEN WITH OVARIAN TUMOURS (1971)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 78 (1971), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: An endocrine assessment was made in 78 post-menopausal women.The urinary excretion of oestriol was greater than 10 μg. per 24 hours in 14 out of 31 cases with malignant ovarian tumours, in 2 out of 24 cases with benign ovarian tumours, and in 6 out of 23 cases without ovarian tumours. Although the urinary oestriol excretion was increased in all 8 cases with mucinous carcinoma it was raised in only 4 out of 18 cases with serous carcinoma. Some of the greatest amounts of urinary oestriol were found in cases without ovarian tumours.The urinary excretion of pregnanediol was increased in 6 out of 18 cases. These six patients also had increased oestriol excretion.The excretion of steroids was normal after oöphorectomy.Tests of adrenal cortical activity and ovarian vein blood analysis also point to the diseased ovary as the site of increased steroid synthesis.The correlation of increased urinary oestriol with vaginal cornification index was fair, but with vaginal bleeding and endometrial activity was poor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1971.tb00303.x
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  • 7
    Electronic Resource
    Electronic Resource
    CULDOSCOPY (1966)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 73 (1966), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1966.tb06072.x
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  • 8
    Electronic Resource
    Electronic Resource
    BASAL SERUM PROLACTIN VALUES AND RESPONSES TO THE ADMINISTRATION OF THYROTROPHIN RELEASING HORMONE (TRH) IN WOMEN WITH AMENORRHOEA (1976)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 83 (1976), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Basal prolactin concentrations were measured in 77 patients presenting with amenorrhoea; 17 per cent were found to have hyperprolactinaemia. The release of prolactin in response to a standard dose of thyrotrophin releasing hormone for amenorrhoeic subjects with normal basal levels of prolactin was within the normal range. However, patients with hyperprolactinaemic amenorrhoea and no evidence of pituitary tumour were found to have a blunted response.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1976.tb00872.x
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  • 9
    Electronic Resource
    Electronic Resource
    LAPAROSCOPIC STERILIZATION AND FOLLOW-UP HYSTEROSALPINGOGRAM (1971)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 78 (1971), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Over a period of three years 910 patients have been subjected to laparoscopic sterilization of which 443 have had a follow-up hysterosalpingogram. The results are discussed.Laparoscopic sterilization is safe and efficient.With only 24 to 36 hours in hospital the method is acceptable to women with home responsibilities. Bridge Hospital, County Durham.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1971.tb00302.x
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  • 10
    Electronic Resource
    Electronic Resource
    Luteinizing hormone releasing hormone analogue in treatment of hypergonadotrophic amenorrhoea (1983)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 90 (1983), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary. The effect of a luteinizing hormone releasing hormone analogue (HOE 766) was studied in four patients with hypergonadotrophic amenorrhoea (resistant ovary syndrome). After an initial phase of stimulation, there was a uniform and sustained suppression of gonadotrophin concentrations in all the patients during the 20–24 days of treatment, presumably due to down-regulation of the pituitary receptors. One patient ovulated after stopping treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1983.tb08964.x
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