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Cardiac and microcirculatory effects of different doses of prostaglandin E1 in man (1987)

Wilkens, J. H. ; Wilkens, H. ; Elger, B. ; [et al.]

Springer

European journal of clinical pharmacology 33 (1987), S. 133-137

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ISSN: 1432-1041

Keywords: prostaglandin E1 ; microcirculation ; inotropic activity ; pre-ejection period ; impedancecardiography ; transcutaneous oxygen pressure ; skin circulation ; haemodynamic effects

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary A cumulative dose response to intravenous PGE1 was established in 12 healthy volunteers. Systolic time intervals, including pre-ejection period (PEP), the ventricular ejection time (VET) and the RR-interval, were continuously determined, and transcutaneous oxygen pressure (tcpO2) was recorded. RR-intervals fell in a dose dependent manner, reaching a significantly lower level at 128 ng·kg−1·min−1 of PGE1 (basal value 842 ms falling to 756 ms). PEP decreased from 89 ms to 74 ms and the ratio PEP/VET decreased from 35% to 30%, indicating increased myocardial contractility. The maximal increase in tcpO2 was 125% on the calf and 60% on the foot. The peak tcpO2 was observed at an infusion rate of 16 ng·kg−1·min−1 PGE1. A decline in tcpO2 was seen at infusion rates 〉64 ng·kg−1·min−1 PGE1, indicating a decrease in skin perfusion. The results indicate that the effects of intravenous PGE1 on skin perfusion occur at a lower threshold than the increase in myocardial contractility. A maximal increase in skin perfusion can be achieved with doses of PGE1 devoid of systemic haemodynamic effects.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00544556

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The kidney of rainbow trout, Salmo gairdneri Richardson, in the acute phase of viral haemorrhagic septicaemia: in vivo experiments on the renal excretion of fluid, electrolytes and protein (1986)

ELGER, B. ; NEUKIRCH, M. ; HENTSCHEL, H.

Oxford, UK : Blackwell Publishing Ltd

Journal of fish diseases 9 (1986), S. 0

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ISSN: 1365-2761

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Biology , Medicine

Notes: Abstract. Kidney function was studied in unanaesthetized rainbow trout, Salmo gairdneri Richardson, with acute infection by VHS virus strain F-l causing viral haemorrhagic septicaemia. The experiments were performed in diseased and control fish with catheters chronically implanted in the dorsal aorta and the urinary bladder. Glomerular clearance of polyfructosan, tubular handling of fluid and electrolytes and urinary excretion of protein were studied. In diseased fish, plasma concentrations of inorganic solutes were reduced, but plasma osmolarity and systemic blood pressure remained unchanged. Glomerular filtration rate and urine flow, both linearly correlated, were reduced from 5.20±0.40 to 3.08±0.66 ml/h/kg and from 2.51±0.15 to 1.63±0.28 ml/h/kg, respectively (x̄±SEM). The urine osmolarity was augmented due to increased Na and Mg concentrations in the urine. Net tubular secretion of Mg was observed in diseased fish whereas net reabsorption of Mg prevailed in the controls. Decreased renal protein excretion rate prevented a renal loss of protein and, therefore, diminished plasma protein concentrations in VHS-infected fish may be attributed to extrarenal pathophysiological mechanisms.