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Cern Collider Results and the Standard Model (1988)

Bagnaia, P ; Ellis, S D

Palo Alto, Calif. : Annual Reviews

Annual Review of Nuclear and Particle Science 38 (1988), S. 659-703

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ISSN: 0163-8998

Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff

Topics: Physics

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1146/annurev.ns.38.120188.003303

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Factors for progression of periodontal diseases (1998)

Ellis, S. D. ; Tucci, M. A. ; Serio, F. G. ; [et al.]

Oxford, UK : Blackwell Publishing Ltd

Journal of oral pathology & medicine 27 (1998), S. 0

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ISSN: 1600-0714

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: Progression factors for periodontal diseases have been suggested by in vitro study of peripheral blood and gingival cells; however, those factors are not established in vivo. This investigation assessed biopsies of three groups of gingival tissues: those adjacent to a 1) 〈inlineGraphic alt="leqslant R: less-than-or-eq, slant" extraInfo="nonStandardEntity" href="urn:x-wiley:09042512:JOP101:les" location="les.gif"/〉3 mm (normal), 2) 4-6 mm, and 3) 〈6 mm gingival sulcus, to determine changes in the gingival microenvironment coincident to the progression of periodontal disease. Superoxide dismutase (SOD) and catalase activity, and IL-12 and bc1-2 levels, were decreased at 〉6 mm; total protein and IL-6 concentrations were increased adjacent to 〉6 mm, as compared to 〈3 and 4-6 mm, sites. Apoptotic cells were evident only within gingiva adjacent to 〉6 mm sites. These data suggest that IL-12 is an important factor in the shift from a TH1 to TH2 cell profile and that a favorable gingival microenvironment for hyper-inflammation may develop coincident to progression of periodontal diseases due to decreased bcl-2 and increased IL-6 concentrations within gingiva. These changes in the gingival microenvironment could impair apoptosis and promote enhanced release of reactive oxygen species (ROS) by phagocytes; decreased catalase and SOD activity could promote accumulation of ROS and result in additional tissue destruction.